Histamine skin reactivity increases with body mass index in Korean children

Kang, Joon Wun; Lee, Keun Hwa; Hong, Seong Chul; Lee, Hye Sook; Lee, Jaechun; Kim, Chang Hoon; Kim, Jeong Hong

doi:10.1016/j.ijporl.2014.11.012

Cited by 7 publications

(8 citation statements)

References 23 publications

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“…In the present study, the wheal size to histamine was positively associated with BMI in children of 3e6 years of age, as supported by two previous studies, 14,15 but no mechanism can be determined based on these results. Nevertheless, some possible explanations can be extracted from the available literature.…”

Section: Discussionsupporting

confidence: 89%

Association of body mass index and season with histamine skin reactivity in Chinese children with allergic rhinitis

Yang¹,

Gu²

2019

Pediatrics & Neonatology

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Section: Discussionsupporting

confidence: 89%

Association of body mass index and season with histamine skin reactivity in Chinese children with allergic rhinitis

Yang¹,

Gu²

2019

Pediatrics & Neonatology

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“…Besides age, we also found a larger histamine MWD in children having obesity. Similar to this finding, Kang et al [11] and Yang and Gu [5] showed an association between histamine reactivity and BMI in children. The superiority of our study was using BMI z-Scores rather than just BMI, showing higher histamine MWD in obese children.…”

Section: Discussion/conclusionsupporting

confidence: 79%

“…The American Academy of Allergy, Asthma and Immunology and European Academy of Allergy and Clinical Immunology recommend reading the test after 15 min, and the cutoff value for histamine and allergen mean wheal diameter (MWD) is accepted as 3 mm [8,9]. Skin response to histamine has been reported to be affected by several personal and environmental factors such as age, sex, ethnicity, body mass index (BMI), application site, and smoke exposure [6,[10][11][12][13][14]. Moreover, allergen MWD and the strength of its association with asthma have been shown to increase with age [15].…”

Section: Introductionmentioning

confidence: 99%

Think Twice before Interpreting the Skin Prick Test as Age, Body Mass Index, and Atopy Affect Reaction Time and Size

Beken

Çelik

Özdemir

et al. 2021

Int Arch Allergy Immunol

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Introduction: The skin prick test (SPT) is a reliable method to confirm sensitization in IgE-mediated allergic diseases; however, it has been reported to be affected by several personal and environmental factors. Our objective was to determine the factors affecting the skin reactivity to histamine and allergens and investigate whether it differs according to age in terms of reading time. Methods: A total of 500 patients, aged 4 months–18 years, were enrolled in the study. Wheal and flare reaction sizes were documented as the mean of the longest and the midpoint perpendicular diameter in the 5th, 10th, 15th, and 20th min. Skin reactivity was compared between children >24 and ≤24 months of age. Results: We found larger histamine and allergen wheal sizes in children >24 months than the ones ≤24 months of age (p < 0.001 and p = 0.007, respectively). The duration of maximum histamine reactivity was 15 min for children >24 months whereas 10 min for children ≤24 months of age. The number of children losing their histamine reactivity after 15 and 20 min was significantly higher in the smaller age-group. Multiple regression analysis revealed a larger histamine reactivity in children >24 months of age, having obesity, and having allergen sensitization (p = 0.002, p = 0.003, and p = 0.018, respectively). Conclusion: It seems more accurate to evaluate SPT after 10 min in children ≤24 months of age. Cutoff values and ideal measurement time according to individual factors such as age, body mass index, or atopy are needed.

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“…It should be noted that the histamine prick result itself is individually variable and depends on age and body mass index of the patient [ 18 ]. This finding was approved in a Korean study where obese children had significantly larger histamine wheals [ 19 ]. In contrast, the histamine tests in atopic children resulted in a significantly smaller flare, but longer itch reaction [ 20 ].…”

Section: Skin Prick Testing – Allergy Screening In the Skinmentioning

confidence: 81%

Debates in allergy medicine: Molecular allergy diagnosis with ISAC will replace screenings by skin prick test in the future

Jensen‐Jarolim

Jensen

Canonica

2017

World Allergy Organization Journal

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In today’s clinical practice patients’ skin is used as screening organ for diagnosing type 1 allergy. According to European guidelines skin prick testing with a panel of 18 allergen extracts is recommended, in the US between 10 to 50 allergens are used. The specificity and sensitivity of skin testing is individually highly variable depending on age, body mass, and skin barrier status. In atopic inflammation skin testing gives more false positive results. Smaller skin area and strain limits prick testing in small children. Although the risk for systemic reactions in skin prick testing is very small, emergency medications must be available. Considering the fact that IgE is the only reliable biomarker for type I allergy, upfront IgE screening with ISAC, followed by fewer skin tests to approve positive sensitizations, is proposed. It is time to arrive in the age of molecular allergy diagnosis in daily patient care.

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Histamine skin reactivity increases with body mass index in Korean children

Cited by 7 publications

References 23 publications

Association of body mass index and season with histamine skin reactivity in Chinese children with allergic rhinitis

Association of body mass index and season with histamine skin reactivity in Chinese children with allergic rhinitis

Think Twice before Interpreting the Skin Prick Test as Age, Body Mass Index, and Atopy Affect Reaction Time and Size

Debates in allergy medicine: Molecular allergy diagnosis with ISAC will replace screenings by skin prick test in the future

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