Histamine-stimulated cyclic AMP formation in the chick pineal gland: Role of protein kinase C

Zawilska, Jolanta B.; Woldan-Tambor, Agata; Nowak, Jerzy Z.

doi:10.1016/s0006-2952(97)00203-7

Cited by 7 publications

(8 citation statements)

References 25 publications

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“…2,13,14 The pivotal role of NE in the control of pineal metabolic activity has been supported by several studies. [15][16][17] Exogenous NE stimulation induces a large increase in melatonin release in the cultured pineal gland 18 and primary pinealocytes, 19,20 while the NE signal is transduced in the pineal gland through β1-, α1-, and α2-adrenergic receptors [21][22][23] and then stimulates cAMP/PKA, 24 PKC, 25 Ca 2+ i , 26,27 cGMP/PKG, 28 and MAPK 29,30 pathways to regulate the activities of melatonin synthesis-related enzymes, including arylalkylamine N-acetyltransferase (AANAT) 18,31 and hydroxyindole-O-methyltransferase (HIOMT). 32 In addition, transcriptional factors ISL1, 30 CRX, 33 and CREB 34 are involved in NE signaling.…”

Section: Introductionmentioning

confidence: 99%

MicroRNA‐7 inhibits melatonin synthesis by acting as a linking molecule between leptin and norepinephrine signaling pathways in pig pineal gland

Qiu

Zhang

Zhou

et al. 2019

Journal of Pineal Research

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MicroRNAs, including microRNA‐7 (miR‐7), are important modulators of numerous gene expressions and the related biological processes. Melatonin is a key hormone regulating daily and seasonal rhythms, in which a variety of positive and negative regulatory factors, such as norepinephrine (NE) and leptin, are involved. However, the interactions among these factors and the mechanisms remain to be elucidated. The aims of the present study were to identify the functions and the related mechanisms of miR‐7 in regulating melatonin synthesis and secretion through in vitro and in vivo experiments in pineal gland of pigs, which is an important animal model for agricultural and biomedical studies. Our results firstly show that miR‐7 is specifically expressed in porcine pinealocytes and negatively regulates melatonin synthesis. The further functional studies show that the dynamic expression levels of miR‐7 are contrary to the melatonin levels throughout the day, and the forced inhibition of endogenous miR‐7 in porcine pinealocytes sharply increases arylalkylamine N‐acetyltransferase (AANAT) expression by 80.0% (P = 0.0031) and melatonin levels by 81.0% (P = 0.0421), whereas miR‐7 over‐expression down‐regulates AANAT expression by 38.6% (P = 0.0004) and melatonin levels by 37.6% (P = 0.0212). In addition, the miR‐7 expression is up‐regulated by leptin through the JAK/STAT3 signaling pathway, and the in vivo intracerebroventricular injection of leptin increases miR‐7 expression by 80.0% (P = 0.0044) in porcine pineal glands and reduces melatonin levels by 57.1% (P = 0.0060) compared with the controls. This functional inhibition of melatonin synthesis by miR‐7 is accomplished by its binding to the 3′‐UTR of Raf1. Further, our results demonstrate that the RAF1/MEK/ERK signaling pathway mediates NE‐induced AANAT expression, whereas leptin attenuates NE's function through miR‐7. Taken together, the results demonstrated that leptin activates the JAK/STAT3 signaling pathway to increase the expression of miR‐7, which acts as a negative regulatory molecule inhibiting NE‐activated RAF1/MEK/ERK signaling pathway by targeting Raf1, resulting in decreased AANAT expression and melatonin synthesis. These findings suggest that miR‐7 is a novel negative regulator of melatonin synthesis and links leptin‐ and NE‐mediated signaling pathways in porcine pineal glands, which will contribute to our understanding in the establishment of the biological rhythms resulting from melatonin.

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Section: Introductionmentioning

confidence: 99%

MicroRNA‐7 inhibits melatonin synthesis by acting as a linking molecule between leptin and norepinephrine signaling pathways in pig pineal gland

Qiu

Zhang

Zhou

et al. 2019

Journal of Pineal Research

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“…Even so, immune mediators and antigens may also directly affect the secretory activity of the pineal gland because it is a part of the brain lacking the blood-brain barrier and all molecules present in the blood can easily access this tissue. A few studies have shown that the secretory activity of pinealocytes could be modified by antigenic stimulation (Markowska et al, 2000), histamine (Zawilska et al, 1997), cytokines (Mucha et al, 1994) and prostaglandins (Voisin et al, 1993). Nonetheless, the spectrum of molecules affecting the pineal gland activity may be much broader.…”

Section: Introductionmentioning

confidence: 99%

The Toll-like receptors mRNA expression profile in the pineal gland of sheep during long and short days

Bochenek¹,

Skipor²,

Kowalewska³

et al. 2015

J. Anim. Feed Sci.

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“…1996, 1997). In line with this assumption, HA has been shown to be capable of stimulating inositol (1,4,5)‐tris‐phosphate (IP 3 ) accumulation in chick tissues (Zawilska et al . 1997, 2001).…”

Section: Discussionmentioning

confidence: 88%

“…Similar observations have been made for the chick pineal gland (Nowak and Sek 1994). The HA‐evoked increase in cAMP formation was significantly reduced by selective inhibitors of protein kinase C, suggesting an important role for this enzyme in the HA‐triggered cascade of biochemical events leading to a large stimulation of cAMP production in avian CNS (Zawilska et al . 1996, 1997).…”

Section: Discussionmentioning

confidence: 99%

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Histamine H₂‐like receptors in chick cerebral cortex: effects on cyclic AMP synthesis and characterization by [³H]tiotidine binding

Zawilska

Woldan-Tambor

Nowak

2002

Journal of Neurochemistry

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In this study, histamine (HA) receptors in chick cerebral cortex were characterized using two approaches: (1) analysis of the effects of HA-ergic drugs on the cAMP-generating system, and (2) radioreceptor binding of [(3) H]tiotidine, a selective H(2) antagonist. HA was a weak activator of adenylyl cyclase in a crude membrane preparation of chick cerebrum. On the other hand, HA (0.1-1000 microm) potently and concentration dependently stimulated cAMP production in [(3) H]adenine pre-labelled slices of chick cerebral cortex, displaying an EC(50) value (concentration that produces 50% of maximum response) of 2.65 microm. The effect of HA was mimicked by agonists of HA receptors with the following rank order of potency: HA >or= 4-methylHA (H(2)) >or= N alpha,N alpha-dimethylHA (H(3) >> H(2) = H(1)) >> 2-methylHA (H(1)) >> 2-thiazolylethylamine (H(1)) >or= R alpha-methylHA (H(3)) >> amthamine, dimaprit (H(2)), immepip (H(3), H(4)). The HA-evoked increase in cAMP production in chick cerebral cortex was antagonized by selective H(2) receptor blockers (aminopotentidine >or= tiotidine > ranitidine >> zolantidine), and not significantly affected by mepyramine and thioperamide, selective H(1) and H(3) /H(4) receptor blockers, respectively. A detailed analysis of the antagonistic action of aminopotentidine (vs. HA) revealed a non-competitive mode of action. The binding of [(3) H]tiotidine to chick cortical membranes was rapid, stable and reversible. Saturation analysis resulted in a linear Scatchard plot, suggesting binding to a single class of receptor binding site with high affinity [equilibrium dissociation constant (K (d)) = 4.42 nm] and high capacity [maximum number of binding sites (B (max) ) = 362 fmol/mg protein]. The relative rank order of HA-ergic drugs to inhibit [(3) H]tiotidine binding to chick cerebrum was: antagonists - tiotidine >> aminopotentidine = ranitidine >or= zolantadine >> thioperamide - triprolidine; agonists - HA >or= 4-methylHA >> 2-methylHA >or=R alpha-methylHA - dimaprit. In conclusion, chick cerebral cortex contains H(2) -like HA receptors that are linked to the cAMP-generating system and are labelled with [(3) H]tiotidine. The pharmacological profile of these receptors is different from that described for their mammalian counterpart. It is suggested that the studied receptors represent either an avian-specific H(2) -like HA receptors or a novel subtype of HA receptors.

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Histamine-stimulated cyclic AMP formation in the chick pineal gland: Role of protein kinase C

Cited by 7 publications

References 25 publications

MicroRNA‐7 inhibits melatonin synthesis by acting as a linking molecule between leptin and norepinephrine signaling pathways in pig pineal gland

MicroRNA‐7 inhibits melatonin synthesis by acting as a linking molecule between leptin and norepinephrine signaling pathways in pig pineal gland

The Toll-like receptors mRNA expression profile in the pineal gland of sheep during long and short days

Histamine H₂‐like receptors in chick cerebral cortex: effects on cyclic AMP synthesis and characterization by [³H]tiotidine binding

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Histamine-stimulated cyclic AMP formation in the chick pineal gland: Role of protein kinase C

Cited by 7 publications

References 25 publications

MicroRNA‐7 inhibits melatonin synthesis by acting as a linking molecule between leptin and norepinephrine signaling pathways in pig pineal gland

MicroRNA‐7 inhibits melatonin synthesis by acting as a linking molecule between leptin and norepinephrine signaling pathways in pig pineal gland

The Toll-like receptors mRNA expression profile in the pineal gland of sheep during long and short days

Histamine H2‐like receptors in chick cerebral cortex: effects on cyclic AMP synthesis and characterization by [3H]tiotidine binding

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Histamine H₂‐like receptors in chick cerebral cortex: effects on cyclic AMP synthesis and characterization by [³H]tiotidine binding