Histaminergic Activation of Endogenous Angiotensin II Fails to Inhibit Alcohol Intake in Rats

Kraly, F. Scott; Jones, Karen

doi:10.1016/s0741-8329(98)00034-2

Cited by 3 publications

(1 citation statement)

References 15 publications

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“…These studies have been criticized (Weisinger et al, 1999a) on the grounds that they mostly used manipulations of peripheral Ang II and so do not negate an opposite effect in brain, or they use a limited time access paradigm to monitor ethanol intake. Kraly and Jones (1999) also could not support the hypothesis that Ang II provides an inhibitory physiological control of ingestion of ethanol, and in fact demonstrated that losartan significantly inhibited alcohol intake in a two-bottle drink test. Finally, the work of Grupp and colleagues that hypothesized that Ang II reduced alcohol intake was tested in alcoholic humans and the results of that study were negative (Naranjo et al, 1991).…”

Section: Discussionmentioning

confidence: 68%

Role of Angiotensin Ii and the Subfornical Organ in the Pharmacological Actions of Ethanol

Grobe

Rowland²,

Katovich

2004

Alcohol and Alcoholism

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Section: Discussionmentioning

confidence: 68%

Role of Angiotensin Ii and the Subfornical Organ in the Pharmacological Actions of Ethanol

Grobe

Rowland²,

Katovich

2004

Alcohol and Alcoholism

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Modeling the binding modes of stilbene analogs to cyclooxygenase-2: a molecular docking study

et al. 2010

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Stilbene analogs are a new class of anti-inflammatory compounds that effectively inhibit COX-2, which is the major target in the treatment of inflammation and pain. In this study, docking simulations were conducted using AutoDock 4 software that focused on the binding of this class of compounds to COX-2 protein. Our aim was to better understand the structural and chemical features responsible for the recognition mechanism of these compounds, and to explore their binding modes of interaction at the active site by comparing them with COX-2 co-crystallized with SC-558. The docking results allowed us to provide a plausible explanation for the different binding affinities observed experimentally. These results show that important conserved residues, in particular Arg513, Phe518, Trp387, Leu352, Leu531 and Arg120, could be essential for the binding of the ligands to COX-2 protein. The quality of the docking model was estimated based on the binding energies of the studied compounds. A good correlation was obtained between experimental logAr values and the predicted binding energies of the studied compounds.

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The effect of telmisartan, an angiotensin receptor blocker, on alcohol consumption and alcohol-induced dopamine release in the nucleus accumbens

Tezcan

Yananlı

Demirkapu

et al. 2021

Alcohol

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Histaminergic Activation of Endogenous Angiotensin II Fails to Inhibit Alcohol Intake in Rats

Cited by 3 publications

References 15 publications

Role of Angiotensin Ii and the Subfornical Organ in the Pharmacological Actions of Ethanol

Role of Angiotensin Ii and the Subfornical Organ in the Pharmacological Actions of Ethanol

Modeling the binding modes of stilbene analogs to cyclooxygenase-2: a molecular docking study

The effect of telmisartan, an angiotensin receptor blocker, on alcohol consumption and alcohol-induced dopamine release in the nucleus accumbens

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