Histaminergic activity in adult rats neonatally lesioned with neurotoxins: DSP-4, 5,7-DHT and 6-OHDA (rodent model of Parkinson's disease)

Thioperamide, an H3 Receptor Antagonist Prevents [3H]Glucose Uptake in Brain of Adult Rats Lesioned as Neonates with 5,7-Dihydroxytryptamine

“…Further study is needed to determine the rationale for thioperamide inhibition of glucose uptake in the brain of rats in which serotoninergic innervation of brain was largely destroyed perinatally (current report). It must be added that in contrast to 6-OHDA effects, a perinatal lesion of the central serotoninergic system with 5,7-DHT decreased the histamine content of adult rat brain (Nowak et al, 2009a). Taking current findings into account, and in reference to previous reports, we conclude and confirm that there is a functional association between histaminergic and serotoninergic systems in mammalian brain.…”

“…We showed that 6-hydroxydopamine (6-OHDA), a neurotoxin for the central dopaminergic system (Kostrzewa 2001) applied to newborn rats in a dose of 134 lg icv reduced [ 3 H]glucose uptake in the brain of adult rats (Kwieciński and Nowak 2009). In those animals an increase of serotoninergic and histaminergic activity was observed in brain (Kostrzewa et al, 1992;Brus et al, 1994;Nowak et al, 2008Nowak et al, , 2009a. Additionally, we found that thioperamide, a central histamine H 3 receptor antagonist, diminished behavioral hyperactivity in rats lesioned with 6-OHDA as neonates (Nowak et al, 2008(Nowak et al, , 2009b.…”

“…The H 3 receptor predominately modulates histamine exocytosis. Thioperamide, an antagonist of H 3 receptors, enhances histamine release (Arrang et al, 1983(Arrang et al, , 1987Schwartz et al, 1991), and modulates the central dopaminergic system (Molina-Hernández et al, 2000;Nowak et al, 2006Nowak et al, , 2008Nowak et al, , 2009a. H 3 receptors represent an alternative target in treatment of the motor dysfunction of Parkinson's disease.…”