Histaminergic regulation of food intake

Khouma, Axelle; Moeini, Moein Minbashi; Plamondon, Julie; Richard, Denis; Caron, Alexandre; Michael, Natalie Jane

doi:10.3389/fendo.2023.1202089

Cited by 10 publications

(3 citation statements)

References 198 publications

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“…Regulating feeding behavior is one of the functions of histamine in the brain (Khouma et al., 2023; Morimoto et al., 2001). Intracerebroventricular infusion of histamine or H 1 R agonists in rats suppresses the food intake (Lecklin et al., 1998; Masaki et al., 2004), whereas intraperitoneal injections of antihistamines, acting as H 1 R inverse agonists, increased food intake.…”

Section: Discussionmentioning

confidence: 99%

Comprehensive mapping of histamine H₁ receptor mRNA in the mouse brain

Futagawa,

Tsuneoka,

Lazarus

et al. 2024

J of Comparative Neurology

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Histamine H1 receptor (H1R) in the central nervous system plays an important role in various functions, including learning and memory, aggression, feeding behaviors, and wakefulness, as evidenced by studies utilizing H1R knockout mice and pharmacological interventions. Although previous studies have reported the widespread distribution of H1R in the brains of rats, guinea pigs, monkeys, and humans, the detailed distribution in the mouse brain remains unclear. This study provides a comprehensive description of the distribution of H1R mRNA in the mouse brain using two recently developed techniques: RNAscope and in situ hybridization chain reaction, both of which offer enhanced sensitivity and resolution compared to traditional methodologies such as radioisotope labeling, which were used in previous studies. The H1R mRNA expression was observed throughout the entire brain, including key regions implicated in sleep–wake regulatory functions, such as the pedunculopontine tegmental nucleus and dorsal raphe. Additionally, strong H1R mRNA signals were identified in the paraventricular hypothalamus and ventromedial hypothalamus, which may explain the potential mechanisms underlying histamine‐mediated feeding regulation. Notably, we identified strong H1R mRNA expression in previously unreported cerebral regions, such as the dorsal endopiriform nucleus, bed nucleus of the accessory olfactory tract, and postsubiculum. These findings significantly contribute to our understanding of the multifaceted roles of H1R in diverse brain functions.

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Section: Discussionmentioning

confidence: 99%

Comprehensive mapping of histamine H₁ receptor mRNA in the mouse brain

Futagawa,

Tsuneoka,

Lazarus

et al. 2024

J of Comparative Neurology

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“…Furthermore, icv anti-TRH antibody suppresses the anorectic action of nesfatin 1, an effect which is histamine mediated [170]. Thus, the control of histamine neurons by TRH TuLH neurons may contribute to the anorectic actions of TRH, since histamine neurons control food-intake [171].…”

Section: Trh Rostral Perifornical Lh Neuron Projectionsmentioning

confidence: 99%

Thyrotropin Releasing Hormone and Food-Intake in Mammals: An Update

Vargas,

Castro Tron,

Charli

et al. 2024

Preprint

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Thyrotropin releasing hormone (TRH; pGlu-His-Pro-NH2) is an intercellular signal produced mainly by neurons. Among the multiple pharmacological effects of TRH, that on food-intake is not well understood. We review data that show that peripheral injection of TRH generally produces a transient anorexic effect, discuss the pathways that might initiate this effect, and explain its short half-life. In addition, central administration of TRH can produce anorexic or orexigenic effects, depending on the site of injection, that are likely due to interaction with TRH receptor 1. Anorexic effects are most notable when TRH is injected into the hypothalamus and the nucleus accumbens, while the orexigenic effect has only been detected by injection into the brain stem. Functional evidence suggests that TRH neurons that are prime candidate vectors for TRH action on food-intake include the caudal raphe nuclei projecting to the dorsal motor nucleus of the vagus, and possibly TRH neurons from the tuberal lateral hypothalamus projecting to the tuberomammillary nuclei. For other TRH neurons, the anatomical or physiological context and impact of TRH in each synaptic domain are still poorly understood. The manipulation of TRH expression in well-defined neuron types will facilitate the discovery of its role in food-intake control in each anatomical scene.

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“…Furthermore, icv anti-TRH antibody suppresses the anorectic action of nesfatin 1, an effect which is histamine mediated [ 169 ]. Thus, the control of histamine neurons by TRH TuLH neurons may contribute to the anorectic actions of TRH since histamine neurons control food intake [ 170 ].…”

Section: In Search Of the Central Circuits Involved In Trh Action On ...mentioning

confidence: 99%

Thyrotropin-Releasing Hormone and Food Intake in Mammals: An Update

Vargas,

Castro Tron,

Rodríguez Rodríguez

et al. 2024

Metabolites

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Thyrotropin-releasing hormone (TRH; pGlu-His-Pro-NH2) is an intercellular signal produced mainly by neurons. Among the multiple pharmacological effects of TRH, that on food intake is not well understood. We review studies demonstrating that peripheral injection of TRH generally produces a transient anorexic effect, discuss the pathways that might initiate this effect, and explain its short half-life. In addition, central administration of TRH can produce anorexic or orexigenic effects, depending on the site of injection, that are likely due to interaction with TRH receptor 1. Anorexic effects are most notable when TRH is injected into the hypothalamus and the nucleus accumbens, while the orexigenic effect has only been detected by injection into the brain stem. Functional evidence points to TRH neurons that are prime candidate vectors for TRH action on food intake. These include the caudal raphe nuclei projecting to the dorsal motor nucleus of the vagus, and possibly TRH neurons from the tuberal lateral hypothalamus projecting to the tuberomammillary nuclei. For other TRH neurons, the anatomical or physiological context and impact of TRH in each synaptic domain are still poorly understood. The manipulation of TRH expression in well-defined neuron types will facilitate the discovery of its role in food intake control in each anatomical scene.

show abstract

Histaminergic regulation of food intake

Cited by 10 publications

References 198 publications

Comprehensive mapping of histamine H₁ receptor mRNA in the mouse brain

Comprehensive mapping of histamine H₁ receptor mRNA in the mouse brain

Thyrotropin Releasing Hormone and Food-Intake in Mammals: An Update

Thyrotropin-Releasing Hormone and Food Intake in Mammals: An Update

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Histaminergic regulation of food intake

Cited by 10 publications

References 198 publications

Comprehensive mapping of histamine H1 receptor mRNA in the mouse brain

Comprehensive mapping of histamine H1 receptor mRNA in the mouse brain

Thyrotropin Releasing Hormone and Food-Intake in Mammals: An Update

Thyrotropin-Releasing Hormone and Food Intake in Mammals: An Update

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Resources

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Comprehensive mapping of histamine H₁ receptor mRNA in the mouse brain

Comprehensive mapping of histamine H₁ receptor mRNA in the mouse brain