Histidine‐rich glycoprotein gene polymorphism in patients with recurrent miscarriage

Lindgren, Karin E; Kårehed, Karin; Karypidis, Helena; Hosseini, Frida; Bremme, Katarina; Landgren, Britt-Marie; Skjöldebrand-Sparre, Lottie; Stavréus-Evers, Anneli; Sundström‐Poromaa, Inger; Åkerud, Helena

doi:10.1111/aogs.12155

Cited by 17 publications

(21 citation statements)

References 12 publications

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“…A single nucleotide polymorphism (SNP), C633T in the HRG-gene causes a change from a proline to a serine at amino acid 186 in the protein, and the allele frequencies in a mixedhas been associated with several aspects of fertility. For instance, an increased prevalence of the minor T-allele was detected among women with primary recurrent miscarriage [Lindgren et al 2013], and among patients undergoing in vitro fertilization (IVF), women homozygous for the minor T-allele had lower pregnancy success rates than women homo-or heterozygous for the major C-allele [Nordqvist et al 2011]. Moreover, homozygous carriers of the minor T-allele received fewer oocytes despite higher levels of administered FSH and had a lower number of fertilized oocytes during IVF treatment [Nordqvist et al 2015].…”

Section: Introductionmentioning

confidence: 99%

Histidine-rich glycoprotein derived peptides affect endometrial angiogenesisin vitrobut has no effect on embryo development

Lindgren

Hreinsson

Helmestam

et al. 2016

Systems Biology in Reproductive Medicine

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(2016) Histidine-rich glycoprotein derived peptides affect endometrial angiogenesis invitro but has no effect on embryo development, Systems Biology in Reproductive Medicine, 62:3, 192-200, DOI: 10.3109/19396368.2016.1156785 To link to this article: https://doi.org/10. 3109/19396368.2016 Histidine-rich glycoprotein (HRG) is an abundant plasma protein involved in multiple biological processes including immunology, vascularisation, and coagulation. These processes are of importance in regulating embryo development and implantation. A specific polymorphism in the HRG gene, HRG C633T, has an impact on various aspects of fertility, such as oocyte quality, endometrial receptivity, and possibly the capacity of the embryo itself to implant. To further examine the potential role of the HRG C633T polymorphism in regulating endometrial angiogenesis and on embryo development, two HRG peptides were constructed. These HRG peptides correspond to the amino acids 169-203 of the protein which, in turn, reflects the C633T polymorphism in the gene. The HRG proline or serine peptides were added to cultures of primary human endometrial endothelial (HEE) cells and to human embryos in vitro. The HRG peptides inhibited vascular endothelial growth factor (VEGF) induced proliferation and migration and promoted tube formation of HEE cells. The embryos were monitored using a time-lapse system (EmbryoScope®). Except for a prolonged time from first cleavage after thawing to development of the morula, no difference in embryo morphokinetics or embryo quality was noted in human embryos cultured in the presence of the HRG proline peptide. Taken together, these results suggest that treatment with a specific HRG peptide might prime the endometrium for implantation and be beneficial for adequate placentation. However, addition of a specific HRG proline peptide to human embryos has no beneficial effects in terms of embryo development.

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Section: Introductionmentioning

confidence: 99%

Histidine-rich glycoprotein derived peptides affect endometrial angiogenesisin vitrobut has no effect on embryo development

Lindgren

Hreinsson

Helmestam

et al. 2016

Systems Biology in Reproductive Medicine

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“…This group was defined as ‘diagnosed with primary recurrent miscarriage’ (no known children either before or after diagnosis) [19,21], and consisted of 43 women who were compared to controls. Age, BMI and smoking did not differ between the groups, but hypothyroidism was more prevalent (p < 0.001) among cases.…”

Section: Resultsmentioning

confidence: 99%

“…HRG has been reported to exist as at least ten naturally occurring single nucleotide polymorphisms (SNPs) [16,17]. One of the SNPs, the HRG C633T SNP, has been postulated to be of relevance for implantation and a successful pregnancy [18] and there is an increased occurrence of the homozygous T/T genotype in patients with primary recurrent miscarriage [19]. …”

Section: Introductionmentioning

confidence: 99%

The histidine-rich glycoprotein A1042G polymorphism and recurrent miscarriage: a pilot study

Elenis

Lindgren

Karypidis

et al. 2014

Reprod Biol Endocrinol

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BackgroundHistidine-rich Glycoprotein (HRG) has previously been shown to have an impact on implantation and fertility. The aim of this study was to investigate if there is an association between the HRG A1042G single nucleotide polymorphism (SNP) and recurrent miscarriage.MethodsThe study was designed as a case-control study and the women were included at University Hospitals in Sweden. 186 cases with recurrent miscarriage were compared with 380 pregnant controls with no history of miscarriage. Each woman was genotyped for the HRG A1042G SNP.ResultsThe results indicated that the frequency of heterozygous HRG A1042G carriers was higher among controls compared to cases (34.7% vs 26.3%; p < 0.05). In a bivariate regression analysis, a negative association was found between recurrent miscarriage and heterozygous A/G carriers both in the entire study population (OR 0.67, 95% CI 0.45 - 0.99; p < 0.05) as well as in a subgroup of women with primary recurrent miscarriage (OR 0.37, 95% CI 0.16 - 0.84; p < 0.05). These results remained even after adjustment for known confounders such as age, BMI and thyroid disease (OR 0.36, 95% CI 0.15 - 0.84; p < 0.05).ConclusionsWomen who are heterozygous carriers of the HRG A1042G SNP suffer from recurrent miscarriage more seldom than homozygous carriers. Thus, analysis of the HRG A1042G SNP might be of importance for individual counseling regarding miscarriage.

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“…In the article by Lindgren et al. , the wrong reference categories were used in the logistic regression analysis in Table 3. The correct values are given in Table 3 below:…”

Section: Factors Associated With Recurrent Miscarriage In a Subgroup mentioning

confidence: 99%

Corrigendum

2016

Acta Obstet Gynecol Scand

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Histidine‐rich glycoprotein gene polymorphism in patients with recurrent miscarriage

Cited by 17 publications

References 12 publications

Histidine-rich glycoprotein derived peptides affect endometrial angiogenesisin vitrobut has no effect on embryo development

Histidine-rich glycoprotein derived peptides affect endometrial angiogenesisin vitrobut has no effect on embryo development

The histidine-rich glycoprotein A1042G polymorphism and recurrent miscarriage: a pilot study

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