Histidine supplementation suppresses food intake and fat accumulation in rats

Kasaoka, Seiichi; Tsuboyama-Kasaoka, Nobuyo; Kawahara, Yumi; Inoue, Setsuko; Tsuji, Makiko; Ezaki, Osamu; Kobayashi, Hideo; Tsuchiya, Takahide; Okuda, Hiroyuki; Nakajima, Shigeru

doi:10.1016/j.nut.2004.08.006

Cited by 101 publications

(73 citation statements)

References 30 publications

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“…2A). This finding supports that of a previous study in which the retroperitoneal fat weight of the H diet group was significantly less than that of the C diet group (16). The epididymal fat weight of the HP diet group showed an increasing tendency compared to the H diet group; however, this difference was not significant (Fig.…”

Section: Resultssupporting

confidence: 91%

“…Since a significant suppression effect on food intake of histidine had been observed at a concentration of 5%, the concentration of histidine in this experiment was set at 5% (16). The concentration of proline was also set to the same 5% concentration to see the influence of proline under the same protein content conditions.…”

Section: Resultsmentioning

confidence: 99%

“…Expression of UCP1 in brown adipose tissues of dietinduced obese (DIO) or diabetic (db/db) mice increased when histamine was administered to the cerebral ventricle, and histamine H1 receptor knockout mouse showed a decreased suppressive effect on food intake and expression of UCP1 (7). On the other hand, intake of histidine, which is a precursor of histamine, also affects the histamine neuron system, and the expression level of UCP1 increased and food intake decreased when a histidine diet of 5% concentration was provided to Wistar rats for 8 d (16).…”

Section: Discussionmentioning

confidence: 99%

“…When histidine is absorbed and crosses the BBB, it is converted into histamine by histidine decarboxylase (HDC) within neuronal cell bodies located in the tuberomammillary nucleus (TMN) of the hypothalamus (11). We previously reported on the anti-obesity effect of histidine using nutrition surveys in humans and animal experiments (12)(13)(14)(15)(16). Oral histidine administration in rats suppressed food intake and the accumulation of body fat (16).…”

mentioning

confidence: 99%

“…We previously reported on the anti-obesity effect of histidine using nutrition surveys in humans and animal experiments (12)(13)(14)(15)(16). Oral histidine administration in rats suppressed food intake and the accumulation of body fat (16). In the human nutrition survey, there was a negative correlation between energy intake and histidine/protein intake (17).…”

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confidence: 99%

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Proline Decreases the Suppressive Effect of Histidine on Food Intake and Fat Accumulation

Asahi

Tanaka

Fujimi

et al. 2016

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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SummaryWe recently suggested that proline might decrease the suppressive effect of histidine on food intake. Our purpose in the present study was to investigate the influence of proline on the suppressive effect of histidine on food intake and accumulation of body fat. Male Wistar rats were divided into four groups and allowed free access to the following diets for 3 wk: control (C), 5% proline (P), 5% histidine (H), or 5% histidine plus 10% proline (HP) diets. Food intake for 7 d and retroperitoneal fat tissue weight at the end of the experimental period of the HP diet group were greater than those of the H diet group, whereas no significant difference existed between the HP diet group and the C diet group. Our results indicate that proline inhibits the influence of histidine on food intake and accumulation of body fat.

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Section: Resultssupporting

confidence: 91%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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