“…The morphology of FDCS can vary widely, and thus it is reasonable to apply the relevant markers CD21, CD23, CD35, D240, and/or SSTR2a liberally when confronted with an epithelioid, syncytial, and/or spindle cell lesion with abundant admixed inflammatory cells. 27 In our case, characteristic morphology with the presence of both S-100 and CD1a positivity by ICC, the diagnosis of LCH was made. In addition to pathological features, clinically bilateral enlargement of parotid in young people can have many clinical differentials of inflammatory processes like sarcoidosis and mumps, which was also the scenario in our case.…”