Histiocytic cytophagic panniculitis

Alegre, V.; Winkelmann, R. K.

doi:10.1016/s0190-9622(89)70018-9

Cited by 87 publications

(46 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The present case was consistent with CHP, 1,3,18 which may occur in a spectrum of disorders, from viral infections to lymphomas. 2,4,5,7,9,14-16 Histo- …”

Section: Discussionsupporting

confidence: 86%

“…It runs a chronic or acute, febrile course with pancytopenia, mucosal ulceration, serositis and hepatosplenomegaly, and terminates in liver failure and death from hemorrhagic diathesis. 1 IgM and IgG antibody titers for viral capsid antigen were < 10, and human T-cell lymphoma virus-1 antibody was negative. The patient underwent a skin biopsy.…”

Section: Background: Cytophagic Histiocytic Panniculitis (Chp) Presenmentioning

confidence: 97%

See 1 more Smart Citation

Pleural Effusion Cytology in a Case of Cytophagic Histiocytic Panniculitis (Subcutaneous Panniculitic T-Cell Lymphoma)

Moriki¹,

Wada²,

Takahashi³

et al. 2000

Acta Cytologica

View full text Add to dashboard Cite

“…The present case was consistent with CHP, 1,3,18 which may occur in a spectrum of disorders, from viral infections to lymphomas. 2,4,5,7,9,14-16 Histo- …”

Section: Discussionsupporting

confidence: 86%

Section: Background: Cytophagic Histiocytic Panniculitis (Chp) Presenmentioning

confidence: 97%

Pleural Effusion Cytology in a Case of Cytophagic Histiocytic Panniculitis (Subcutaneous Panniculitic T-Cell Lymphoma)

Moriki¹,

Wada²,

Takahashi³

et al. 2000

Acta Cytologica

View full text Add to dashboard Cite

“…It is characterized clinically by a recurrent high fever, panniculitis in multiple regions, pancytopenia and disseminated the bone marrow, liver, spleen and lymph nodes, as well as fat intravascular coagulation with a high incidence of mortality tissue. Microscopic examination of these affected tissues re- (12). The phagocytosing histiocytes characteristic to this dis-vealed the presence of the so called "bean bag" cytophagic order were observed throughout the affected tissues including cells reported by Crotty and Winkelmann (13).…”

Section: Discussionsupporting

confidence: 66%

“…These results strongly indicate the necessity of intensive chemotherapy targeted to T cells in the treatment of CHP. Histological examinationof the subcutaneousnodules of CHPpatients, including the present patient, reveals a chronic inflammation of the fat tissue infiltrated mainly by the benignappearing T lymphocytes and the occasional phagocytic histiocyte (12,22). It is conceivable that phagocytosis by histiocytes is activated by lymphokines released from proliferated T cells.…”

Section: Chp Can Be Classified As a Hemophagocytic Syndrome (Hps)mentioning

confidence: 50%

Cytophagic Histiocytic Panniculitis Improved by Combined CHOP and Cyclosporin A Treatment.

et al. 1999

View full text Add to dashboard Cite

In a 31-year-old Japanese man with cytophagic histiocytic panniculitis (CHP) remission was achieved by a combination of combined chemotherapy CHOPand cyclosporin A treatment. He was admitted to our hospital in January 1994 with recurrent high fever of 40.2°C and tender and violaceous subcutaneous nodules on his trunk, arms and legs. Hedeveloped pancytopenia, hemorrhagic diathesis, liver dysfunction. Histological examination of the biopsied subcutaneous nodule revealed a lobular panniculitis with fat necrosis and a massive infiltration of histiocytes phagocytosing nuclear debris. He was treated initially with 40 mg/day prednisolone. However, following a reduction in prednisolone dosage, his symptoms reappeared. CHOP(cyclophosphamide, doxorubicin, vincristine and prednisolone) therapy was then initiated. Three courses of CHOPtreatment alleviated his symptomsand cyclosporin A was used to maintain his condition for 15 months. His medication was then discontinued and he has been in complete remission for 10 months. Combined treatment of cyclosporin A and CHOPcombined chemotherapy was shown to be effective for this patient with severe CHP. (Internal Medicine 38: 296-301, 1999)

show abstract

“…To our knowledge this patient is the youngest case re~ ported [1,3,6,7]. The search for aetiological factors, including infection-associated haemophagocytic syndrome, was negative.…”

Section: Case Reportmentioning

confidence: 83%