Histiocytic infiltration in ulcerative colitis, simulating malignancy

Herpes simplex virus colitis in ulcerative colitis, simulating malignancy

“…The interface of viable colonic mucosa and ulcer tissue was sharply delineated and did not show viropathic cell changes. Large areas had the low‐power appearance of an infiltrative process with significant nuclear atypia, similar to the case presented by Farrell et al ., 1 features which contributed to an initial working diagnosis of haematolymphoid neoplasm in our case also. Additional immunoperoxidase studies for HSV and electron microscopy ultimately helped to arrive at the correct diagnosis.…”

“…Herein, we report a case of herpes simplex virus (HSV) colitis complicating ulcerative colitis, in which the histological features were very similar to those described by Farrell et al 1 . The patient was a 31‐year‐old woman transferred to our institution from an outlying hospital in May 1999 for surgical management of medically refractory ulcerative colitis.…”

“…Sir : Recently, Histopathology published a case of histiocytic mucosal infiltration in a patient with ulcerative colitis, simulating malignancy 1 . The authors described a relatively monotonous, phagocytic/histiocytic infiltrate within the lamina propria which appeared to efface the colonic epithelium.…”