Histiocytic necrotizing lymphadenitis (Kikuchi’s disease) with aseptic meningitis

Satō, Yoshihiro; Kuno, Haruko; Ōizumi, Kōtaro

doi:10.1016/s0022-510x(99)00037-4

Cited by 69 publications

(64 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Extranodal involvement rarely occurs in KFD but includes skin lesions, 21 arthritis, 22 aseptic meningitis, 11,23 and unexpected death. 12,24 Two reports independently described that children with KFD experienced a severe clinical course with multiorgan failure after the use of multiple antituberculous drugs.…”

Section: Discussionmentioning

confidence: 99%

Kikuchi-Fujimoto Disease With Prolonged Fever in Children

2004

View full text Add to dashboard Cite

ABSTRACT. We reviewed 12 patients who had Kikuchi-Fujimoto disease (KFD) and presented with prolonged fever and lymphadenopathy. The clinical and laboratory aspects of the patients confirmed by excisional lymph node biopsy were analyzed. The mean age of the children was 11.0 ؎ 3.0 years (range: 6 -15 years). The male-to-female ratio was 1.4:1. The median duration of fever before admission and the total duration of fever was 13 days (range: 7-65 days) and 19.5 days (range: 9 -75 days), respectively. One patient had supraclavicular lymphadenopathy, 10 had cervical involvement, and 1 had axillary lymphadenopathy. All of the histologic findings of the lymph node biopsies showed the characteristic findings consistent with KFD, such as paracortical necrosis with karyorrhexis and an increase in the number of phagocytic histiocytes and atypical lymphocytes. As for the laboratory findings, leukopenia (3600 ؎ 900 per mm 3 ), anemia (hemoglobin 11.4 ؎ 1.2 g/dL), an elevated erythrocyte sedimentation rate (44 ؎ 18 mm/hour), and a relatively low C-reactive protein level (1.3 ؎ 1.1 mg/dL) were noted. Eight patients received conservative therapy with antipyretics, and 3 patients were treated with prednisolone. KFD is a rare disease yet should be considered in the differential diagnosis for older children with prolonged fever and lymphadenopathy.

show abstract

Section: Discussionmentioning

confidence: 99%

Kikuchi-Fujimoto Disease With Prolonged Fever in Children

2004

View full text Add to dashboard Cite

show abstract

“…The etiology of KFD is still unknown, although an association with viral infections or autoimmune processes has been proposed [2]. Involvement of central nervous system (CNS) has been reported in several cases, most of which presented as aseptic meningitis [3]. Acute cerebellar symptom as a manifestation of KFD is very rare.…”

Section: Introductionmentioning

confidence: 99%

Kinetic tremor and cerebellar ataxia as initial manifestations of Kikuchi–Fujimoto's disease

Moon

Kim

Koo

et al. 2009

Journal of the Neurological Sciences

View full text Add to dashboard Cite

“…15 Analysis of CSF typically shows a lymphocytic pleocytosis (with white cell counts that can go up to 1685 cells/ml), and slightly elevated glu cose and protein levels. Aseptic meningitis is believed to be secondary to an autoimmune response in which infil tration of the neural tissue by lymphocytes occurs.…”

mentioning

confidence: 99%