Histiocytic sarcoma of the parotid gland region

Abstract

Histiocytic sarcoma (HS) is a malignant neoplasm showing the morphological and immunophenotypic features of mature histiocytes. Reported herein is a case of HS of the parotid gland region. A 53-year-old woman noticed a swelling of the right preauricular area. Preoperative fine needle aspiration cytology showed an admixture of pleomorphic atypical cells and mature lymphocytes. She underwent total parotidectomy. Grossly, the tumor was located at the parotid gland to subcutaneous tissue, and showed infiltrative growth with massive necrosis and hemorrhage. Microscopically, the tumor was composed of marked pleomorphic cells with eosinophilic cytoplasm. Bizarre multinuclear giant cells were scattered and intermingled. Tumor cells were positive for CD68 (KP-1 and PG-M1), CD163, S-100 protein, CD1a, CD4 and CD31, but negative for CD3, CD20, CD21, CD79a, DEC205 and langerin, immunohistochemically. Monoclonal proliferation of B cells was not confirmed on polymerase chain reaction for IgH. The patient had recurrent lesions in the pelvis and stomach 5 months after parotidectomy and died of the disease 10 months after the operation.

Caracterização imunoistoquímica de neoplasias de bexigas associadas à hematúria enzoótica bovina

“…A molécula de adesão celular endotelial plaquetária 1 (PECAM-1) também conhecida como CD31 mantêm a integridade endotelial através da adesão célula-célula ou célula-matriz extracelular e auxilia na passagem das células sanguíneas para a luz dos vasos (BEHAR et al, 1996;BLANKENBERG;BARBAUX;TIRET, 2003;LISTI et al, 2004), pode se expressar na superfície de células endoteliais, plaquetas e leucócitos (ELRAYESS; TALMUD, 2005), como macrófagos e histiócitos (AKIBA et al, 2011 …”

Morphological Distinction of Histiocytic Sarcoma from Other Tumor Types in Bernese Mountain Dogs and Flatcoated Retrievers

“…The characteristic kidney-shaped nuclei have also been reported before in canine HS (33,39,46) and in human HS (47) and IDCS (14). Indentations of the nucleus have been reported in the canine literature (1,7,24,26,28) as well as in human HS (41) and IDCS (48), and a combination of indentations, grooves or folds in human HS (43,49), IDCS (14) and LCH (50). This indicates that a canine subtype comparable to human LCH/LCS may also exist.…”

“…In humans, multinucleated giant cells are less frequently present in HS (43), as well as in IDCS (13), FDCS (44) and indeterminate DCS (45), which may imply a more malignant nature of HS in canines. The characteristic kidney-shaped nuclei have also been reported before in canine HS (33,39,46) and in human HS (47) and IDCS (14).…”

Orbital Histiocytic Sarcoma in a 2-Year-Old Child

“…3 HS most commonly presents in the lymph nodes, bone marrow, intestines, skin, and spleen. 3 Only a few cases of HS presenting in the head and neck region have been described including the, palate 2 , nasal cavity 3 , parotid gland 4 , zygomatic, preauricular region 5 , and forehead. 6 To our knowledge, there are no reports of HS occurring in the orbit of a child.…”

“…3,4 Immunohistochemistry and cytochemistry typically reveal lysozyme positive, vimentin positive, CD4, CD45, CD68, and CD163 positive cells that are negative for other T and B cell markers, langerin, CD1a, myeloperoxidase, and epithelial markers. Focal S100 positivity has been noted in some studies.…”