Histiocytic syndromes: A review

Gianotti, F; Caputo, Ruggero

doi:10.1016/s0190-9622(85)70181-8

Cited by 249 publications

(160 citation statements)

References 57 publications

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“…Collagen phagocytosis has been described previously in multiccntric reticulohistiocytosis and in other conditions. but not, to our knowledge, in other histiocytoscs (6,7). The demonstration of hemosidcrin raised the possibility of pigmented villonodular synovitis (PVNS), but the amount of hemosidcrin was small.…”

Section: Discussionmentioning

confidence: 72%

A unique presentation of multicentric reticulohistiocytosis in pregnancy

Conaghan

Miller

Dowling

et al. 1993

Arthritis & Rheumatism

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We describe a patient with multicentric reticulohistiocytosis who presented, during the second trimester of pregnancy, with symmetric polyarthritis, marked erythematous, pulsatile synovial swelling of the distal interphalangeal joints of both hands, and widespread telangiectasias. She did not have the typical skin manifestations of multicentric reticulohistiocytosis. The erythema and pulsatility of the synovial swellings of the distal interphalangeal joints resolved after delivery, but she continued to have widespread active synovitis, which did not resolve until treatment with low-dose oral methotrexate was instituted. delivery. The destructive polyarthritis persisted after pregnancy, but she had an excellent, early response to treatment with low-dose oral methotrexate. CASE REPORTThe patient. a 3.5-year-old East Timorese woman, presented to us in September I990 at 24 weeks gestation, with a I-month history of bleeding gums and facial rash, and a 3-month history of stiffness in the small joints ofthe hands and both knees and fatigue. A ganglion had been excised from the left wrist at another hospital 4 months before conception. Past obstetric history included I first-trimester spontaneous abortion and I successful pregnancy complicated by third-trimester gestational diabetes. She had no rash or joint symptoms during the previous pregnancies. There was no previous personal or family history to suggest a bleeding diathcsis.On physical examination at presentation. there were prominent telangiectasias over her face. oral mucosa and tongue, upper chest, and arms. She had marked erythematous synovial swelling over the DIP joints of both hands ( Figure I ) . On palpation. the synovial swellings were found to be pulsatile. and pulsed with the heart beat. There was mild tenderness over the joint lines. Effusions o f the proximal interphalangeal (PIP) joints of both hands and both knees were present, but without associated erythema or pulsation. There was a reducible flexion deformity of the right fifth DIP joint. There were no cutaneous nodular lesions. A soft systolic flow murmur was present, and uterine fundus height was compatible with pregnancy duration.Initial laboratory investigations revealed a mild

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Section: Discussionmentioning

confidence: 72%

A unique presentation of multicentric reticulohistiocytosis in pregnancy

Conaghan

Miller

Dowling

et al. 1993

Arthritis & Rheumatism

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“…LCH is characterized clinically by various combinations of systemic and cutaneous manifestations. LCH consists of Letterer-Siwe disease, HandSchuller-Christian disease, eosinophilic granuloma, and congenital self-healing reticulohistiocytosis 1 .…”

Section: Discussionmentioning

confidence: 99%

“…The recognized clinical variants of LCH include Letterer-Siwe disease, HandSchuller-Christian disease, eosinophilic granuloma, and congenital self-healing reticulohistiocytosis 1 . We report a 50-year-old man with brown lichenoid patches, unusual cutaneous presentation of LCH, on left dorsal foot.…”

Section: Introductionmentioning

confidence: 99%

Langerhans Cell Histiocytosis Presenting as Brown Lichenoid Patches

et al. 2009

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Langerhans cell histiocytosis (LCH) is related diseases characterized by proliferation of Langerhans cell with involvement of bone, skin, lung and other organs. LCH usually occurs in childhood and are presented as multiple small papules or eczematoid lesion mostly. We report a 50-year-old man with 3 brown lichenoid patches on left dorsal foot. He was diagnosed pulmonary LCH 5 years ago. Typical LC cells on skin lesion and CD1 complex positive staining confirm the diagnosis of LCH. We consider brown lichenoid patches may be a previously unreported cutaneous presentation in cutaneous or multisystem LCH.

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“…4 De acuerdo con el tamaño, Gianotti propone dos formas: la micronodular, más frecuente, con un tamaño menor de 10 mm, y la macronodular, mayor de 10 mm. 5 Esta última forma está relacionada, con más frecuencia, con afectación sistémica; el compromiso ocular es el más habitual. Excepcionalmente, se encuentra compromiso de otros órganos, entre ellos, del sistema nervioso central, pulmones, hígado y bazo.…”

Section: Conflicto De Interesesunclassified

Xantogranuloma juvenil solitario congénito. Caso clínico

et al. 2017

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Presentación de casos clínicos RESUMENEl xantogranuloma juvenil es una patología benigna y representa la forma más común de histiocitosis de células no Langerhans. Está caracterizado por la presencia de pápulas o nódulos firmes de coloración rosada o amarillo amarronada, que comprometen, principalmente, la piel y, de forma excepcional, otros órganos. Es una entidad autolimitada con una involución espontánea en los primeros 5 años de vida. Presentamos a una paciente de 1 mes de vida con una lesión congénita en el abdomen, cuya histopatología mostró la presencia de células gigantes multinucleadas de Touton, características de esta patología. Destacamos la presentación infrecuente de este tipo de lesión y la importancia de los múltiples diagnósticos diferenciales que se deben tener en cuenta debido a la edad de la paciente y a sus características. Palabras clave: histiocitosis de células no Langerhans, xantogranuloma juvenil, pared abdominal. ABSTRACTJuvenile xanthogranuloma is a bening pathology and it represents the most common form of non-Langerhans cell histiocytosis. It is characterized by the presence of papules or firm nodules of a pinkish or yellow-brownish nature, which mainly compromise the skin and, exceptionally, other organs. It is a self-limited entity having a spontaneous regression during the first five years of life. We report the case of a one-month-old patient who presented a congenital tumor in the abdomen, whose histopathology showed the presence of multinucleated giant Touton cells, which are typical of this pathology. We emphasize the rare occurrence of this type of lesion and the importance of the multiple differential diagnosis to be taken into account due to the age of the patient and the characteristics of the lesion.

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Histiocytic syndromes: A review

Cited by 249 publications

References 57 publications

A unique presentation of multicentric reticulohistiocytosis in pregnancy

A unique presentation of multicentric reticulohistiocytosis in pregnancy

Langerhans Cell Histiocytosis Presenting as Brown Lichenoid Patches

Xantogranuloma juvenil solitario congénito. Caso clínico

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