Histiocytic ulcerative colitis in boxer dogs in the UK

Hall, Edward J.; Rutgers, H. C.; Scholes, S. F. E.; Middleton, Deborah; Tennant, Bryn; King, N. M.; Kelly, D. F.

doi:10.1111/j.1748-5827.1994.tb03800.x

Cited by 20 publications

(37 citation statements)

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“…The inclusion of dogs from Australia and the United States in the present study and dogs from the United Kingdom and United States in the previous study 12 demonstrates that intramucosal colonization of E. coli in HUC is not a consequence of a geographically restricted infectious agent. In agreement with previous reports, 4,5,10,11 we observed a poor clinical response in all dogs treated with various combinations of prednisolone, c sulfasalazine, d and nonenrofloxacin a antimicrobials. We found that enrofloxacin a (mean 7 mg/kg q24 h) for a mean duration of 9.5 weeks resulted in a positive clinical response in all dogs within 2 weeks of administration, and this was sustained in 6/7 dogs, resulting in median disease‐free interval to date of 47 months (17–62 months).…”

Section: Discussionsupporting

confidence: 93%

“…Granulomatous colitis of Boxer dogs was first described by Van Kruiningen in a kennel of Boxer dogs in 1965 1 . Some subsequent reports of this disease use the term histiocytic ulcerative colitis (HUC), 2–5 and this term is more familiar to many veterinarians. The pathognomonic lesion of HUC in Boxer dogs is mucosal infiltration with large numbers of macrophages staining positively with periodic acid‐Schiff (PAS), and is usually accompanied by mucosal ulceration and loss of goblet cells 1 .…”

mentioning

confidence: 99%

“…isolated from colonic mucosa were unsuccessful 9 . Thus HUC has until recently been regarded as an idiopathic immune‐mediated disease that typically responds poorly to treatment with empirical therapies such as dietary change, antibiotics, and immunosuppressive agents 4,5 …”

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confidence: 99%

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Remission of Histiocytic Ulcerative Colitis in Boxer Dogs Correlates with Eradication of Invasive Intramucosal Escherichia coli

Mansfield

James

Craven

et al. 2009

Veterinary Internal Medicne

130

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Background: Historically, histiocytic ulcerative (HUC) (or granulomatous) colitis of Boxer dogs was considered an idiopathic immune-mediated disease with a poor prognosis. Recent reports of dramatic responses to enrofloxacin and the discovery of invasive Escherichia coli within the colonic mucosa of affected Boxer dogs support an infectious etiology.Hypothesis: Invasive E. coli is associated with colonic inflammation in Boxer dogs with HUC, and eradication of intramucosal E. coli correlates with clinical and histologic remission.Animals: Seven Boxer dogs with HUC. Methods: Prospective case series. Colonic biopsies were obtained at initial evaluation in 7 dogs, and in 5 dogs after treatment with enrofloxacin. Biopsies were evaluated by standardized histopathology, and fluorescence in situ hybridization (FISH) with probes to eubacteria and E. coli.Results: Intramucosal E. coli was present in colonic biopsies of 7/7 Boxers with HUC. Clinical response was noted in all dogs within 2 weeks of enrofloxacin (7AE3.06 mg/kg q24 h, for 9.5AE3.98 weeks) and was sustained in 6 dogs (median disease-free interval to date of 47 months, range 17-62). FISH was negative for E. coli in 4/5 dogs after enrofloxacin. E. coli resistant to enrofloxacin were present in the FISH-positive dog that relapsed.Conclusions and Clinical Relevance: The correlation between clinical remission and the eradication of mucosally invasive E. coli during treatment with enrofloxacin supports the causal involvement of E. coli in the development of HUC in susceptible Boxer dogs. A poor response to enrofloxacin treatment might be due to colonization with enrofloxacin-resistant E. coli.

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Section: Discussionsupporting

confidence: 93%

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confidence: 99%

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Remission of Histiocytic Ulcerative Colitis in Boxer Dogs Correlates with Eradication of Invasive Intramucosal Escherichia coli

Mansfield

James

Craven

et al. 2009

Veterinary Internal Medicne

130

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“…Some breeds are known to be pre-disposed to gastrointestinal disorders, such as Siamese cats, Soft Coated Wheaten Terriers, Boxers, and German Shepherds [15,18,22]. This study included one Siamese cat, one Soft Coated Wheaten Terrier, two German Shepherds, and one Boxer.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of endoscopically obtained duodenal biopsy samples from cats and dogs in an adapter-modified Ussing chamber

et al. 2014

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This study was conducted to evaluate an adapter-modified Ussing chamber for assessment of transport physiology in endoscopically obtained duodenal biopsies from healthy cats and dogs, as well as dogs with chronic enteropathies. 17 duodenal biopsies from five cats and 51 duodenal biopsies from 13 dogs were obtained. Samples were transferred into an adapter-modified Ussing chamber and sequentially exposed to various absorbagogues and secretagogues. Overall, 78.6% of duodenal samples obtained from cats responded to at least one compound. In duodenal biopsies obtained from dogs, the rate of overall response ranged from 87.5% (healthy individuals; n = 8), to 63.6% (animals exhibiting clinical signs of gastrointestinal disease and histopathological unremarkable duodenum; n = 15), and 32.1% (animals exhibiting clinical signs of gastrointestinal diseases and moderate to severe histopathological lesions; n = 28). Detailed information regarding the magnitude and duration of the response are provided. The adapter-modified Ussing chamber enables investigation of the absorptive and secretory capacity of endoscopically obtained duodenal biopsies from cats and dogs and has the potential to become a valuable research tool. The response of samples was correlated with histopathological findings.

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“…The disease is well recognized in young Boxer dogs (Hall et al, 1994) and there is an apparent familial predisposition among affected dogs (Hall et al, 1992). Early lesions are characterized histopathologically by the presence of a mixed inflammatory infiltrate (neutrophils and macrophages) subjacent to degenerative epithelium (Russell et al, 1971).…”

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confidence: 99%

Canine histiocytic syndrome manifested as ulcerative gastroenterocolitis, skin lesions and lymphadenopathy - a case report

Révajová¹,

Levkut²,

Kozak³

et al. 2004

Vet. Med.

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Histiocytic syndrome was diagnosed in a 7-year-old boxer bitch using histological and immunohistochemical methods. Necropsy confirmed the presence of enlarged superficial lymph nodes, two large ulcerated oval cutaneous masses one on the le� lateral thoracic wall and one near to the vulva. In the gastrointestinal tract there were multiple ulcers apparently overlying nodules located in the submucosa of stomach, ulcers in the ileocaecal valve, and enlargement of lymphoid nodules in the small intestine manifested ulcerative gastroenteritis. Histologically, the thoracic wall mass showed infiltration of the tissue by macrophages with cytoplasmic vacuoles. The vacuoles contained PAS-positive polysaccharides. The macrophages were positive for alpha-1-antitrypsin and lysozyme by immunostaining. Lysozyme is a marker for phagocytic macrophages/histiocytes and may be used to confirm cells of this lineage in cases when there is any doubt.

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Histiocytic ulcerative colitis in boxer dogs in the UK

Cited by 20 publications

References 15 publications

Remission of Histiocytic Ulcerative Colitis in Boxer Dogs Correlates with Eradication of Invasive Intramucosal Escherichia coli

Remission of Histiocytic Ulcerative Colitis in Boxer Dogs Correlates with Eradication of Invasive Intramucosal Escherichia coli

Evaluation of endoscopically obtained duodenal biopsy samples from cats and dogs in an adapter-modified Ussing chamber

Canine histiocytic syndrome manifested as ulcerative gastroenterocolitis, skin lesions and lymphadenopathy - a case report

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