Histiocytoid Sweet syndrome may indicate leukemia cutis: A novel application of fluorescence in situ hybridization

Chavan, Rahul N.; Cappel, Mark A.; Ketterling, Rhett P.; Wada, David A.; Rochet, Nicole M.; Knudson, Ryan A.; Gibson, Lawrence E.

doi:10.1016/j.jaad.2014.01.874

Cited by 60 publications

(36 citation statements)

References 17 publications

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“…Moreover, in 2014, Chavan et al . reported that histiocytoid SS may indicate leukemia cutis . In our case, the results of the immunostaining did not indicate histiocytoid SS.…”

Section: Discussioncontrasting

confidence: 68%

Granulocyte colony‐stimulating factor‐induced granulomatous dermatitis with enlarged histiocytes clinically manifesting as painful edematous nodules with high fever similar to Sweet's syndrome

Ozaki

Funasaka

Takubo

et al. 2015

The Journal of Dermatology

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A 72-year-old woman with a history of diffuse large B cell lymphoma and recent recurrence visited our department complaining of several painful edematous nodules with blisters on her face. She had iteratively developed cutaneous eruptions after every treatment with granulocyte colony-stimulating factor (G-CSF) for neutropenia, and each time the eruption improved after the cessation of the G-CSF treatment. The blisters became crusty and the skin lesions slightly improved, but on the 24th hospital day, the eruption formed painful erythematous nodules with erosion, and the patient also developed a high fever of up to 38°C. A biopsy specimen showed a dermal infiltrate of increased and enlarged plump histiocytes, some of which indicated karyomitosis with a small number of lymphocytes. No increase in the number of eosinophils or neutrophils was noted. These eruptions lasted for 15 days and disappeared with the recovery of the peripheral blood count and attendant cessation of G-CSF. We diagnosed this case as G-CSF-induced granulomatous dermatitis with enlarged histiocytes. Several cases with maculopapular rash and dermal inflammatory infiltrate composed of interstitially arranged large histiocytes have been reported. However, to the best of our knowledge, this is the first case report of G-CSF-induced granulomatous dermatitis with enlarged histiocytes clinically manifesting as painful edematous nodules with a high fever, similar to Sweet's syndrome. We speculated that the infiltrating cells were not neutrophils but histiocytes, presumably because of agranulocytosis.

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“…Moreover, in 2014, Chavan et al . reported that histiocytoid SS may indicate leukemia cutis . In our case, the results of the immunostaining did not indicate histiocytoid SS.…”

Section: Discussioncontrasting

confidence: 68%

Granulocyte colony‐stimulating factor‐induced granulomatous dermatitis with enlarged histiocytes clinically manifesting as painful edematous nodules with high fever similar to Sweet's syndrome

Ozaki

Funasaka

Takubo

et al. 2015

The Journal of Dermatology

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“…Immunohistochemical studies show that the atypical cells demonstrate positive staining with CD68 and myeloperoxidase, indicating a myeloid lineage. The most challenging diagnosis is leukaemia cutis, and in a recent report, histiocytoid Sweet syndrome was considered an indicator of leukaemia cutis, especially in the context of myelodysplastic syndromes …”

Section: Sweet Syndromementioning

confidence: 99%

Pyoderma gangrenosum and Sweet syndrome: the prototypic neutrophilic dermatoses

Wallach¹,

Vignon‐Pennamen

2015

Br J Dermatol

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Pyoderma gangrenosum, a dramatic ulcerative skin disease, and Sweet syndrome, a papular dermatosis, were described independently. It was subsequently shown that they share many characteristics, including clinical overlap and the frequent association with multisystemic disorders. The group of the neutrophilic dermatoses encompasses these two dermatoses, as well as other conditions having in common an aseptic neutrophilic infiltrate predominating in the epidermis and/or the dermis and/or the subcutis. Some patients also experience neutrophilic infiltrates in other organs, defining the neutrophilic disease. Recent research suggests that the neutrophilic dermatoses could be considered as the cutaneous expression of the autoinflammation, an aberrant hyperproduction of interleukin-1. Autoinflammation is responsible for monogenic diseases, and is also involved in the mechanism of many polygenic conditions, including the neutrophilic dermatoses.

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“…[4,12] The main differential diagnoses of histiocytoid Sweet's syndrome include interstitial granuloma annulare and interstitial granulomatous dermatitis, both showing a denser, "bottom-heavy," inflammatory infiltrate of histiocytes with large, pleomorphic nuclei that in some small foci are arranged in palisades surrounding degenerated basophilic collagen; [1] methotrexate-induced rheumatoid papules, which appears only in methotrexate-treated patients; and leukemia cutis that shows nodular dermal infiltrates of medium-sized, round to oval mononuclear cells that express lysozyme, myeloperoxidase, CD43, CD45, and CD68. [13] A cytologic examination of peripheral blood should be performed and fluorescence in situ hybridization may be useful to detect underlying cytogenetic abnormalities in histiocytoid Sweet's syndrome when there is an identifiable chromosomal abnormality.…”

mentioning

confidence: 99%

Histiocytoid sweet syndrome related to bortezomib: A mimicker of cutaneous infiltration by myeloma

Llamas‐Velasco¹,

Concha-Garzón²,

Fraga³

et al. 2015

Indian J Dermatol Venereol Leprol

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Histiocytoid Sweet syndrome may indicate leukemia cutis: A novel application of fluorescence in situ hybridization

Cited by 60 publications

References 17 publications

Granulocyte colony‐stimulating factor‐induced granulomatous dermatitis with enlarged histiocytes clinically manifesting as painful edematous nodules with high fever similar to Sweet's syndrome

Granulocyte colony‐stimulating factor‐induced granulomatous dermatitis with enlarged histiocytes clinically manifesting as painful edematous nodules with high fever similar to Sweet's syndrome

Pyoderma gangrenosum and Sweet syndrome: the prototypic neutrophilic dermatoses

Histiocytoid sweet syndrome related to bortezomib: A mimicker of cutaneous infiltration by myeloma

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