"Histiocytosis X" – A Rare  Case Report

Azariah, Emmanuel; Chandrasekaran, Deepak; Ravindran, C; Balasubramaniam, Sivaramakrishnan; Jagdish, Eswari

doi:10.7860/jcdr/2016/21614.8691

Cited by 3 publications

(4 citation statements)

References 16 publications

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“…Multisystemic disease needs systemic chemotherapy. The most common agents used in different combination regimens and several cycles are corticosteroids, vinblastine, etoposide, cytarabine, 6‐mercapto purine, methotrexate, 2‐chlorodeoxyadenosine, cyclosporine, thalidomide and others …”

Section: Discussionmentioning

confidence: 99%

“…Other therapies include supervoltage therapy, supportive therapy, control of diabetic insipidus and surgery in specific indications …”

Section: Discussionmentioning

confidence: 99%

“…The most common agents used in different combination regimens and several cycles are corticosteroids, vinblastine, etoposide, cytarabine, 6-mercapto purine, methotrexate, 2-chlorodeoxyadenosine, cyclosporine, thalidomide and others. 19,20 Other therapies include supervoltage therapy, supportive therapy, control of diabetic insipidus and surgery in specific indications. 18,20 In this case, considering that multiple lesions affecting bones of the skull-facial region may be at high risk of squeal, a systemic chemotherapy treatment was chosen, in addition to surgical excision surgery.…”

Section: C H O F T H E M a X I L L A E T R E A T M E N T A N D O mentioning

confidence: 99%

“…19,20 Other therapies include supervoltage therapy, supportive therapy, control of diabetic insipidus and surgery in specific indications. 18,20 In this case, considering that multiple lesions affecting bones of the skull-facial region may be at high risk of squeal, a systemic chemotherapy treatment was chosen, in addition to surgical excision surgery. 21 A treatment with vinblastine and prednisone for 6 months was programmed, considering that such drug association demonstrated better results when compared to a single-agent therapy.…”

Section: C H O F T H E M a X I L L A E T R E A T M E N T A N D O mentioning

confidence: 99%

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Multidisciplinary approach in a case of Hand–Schüller–Christian disease with maxillary involvement

Cazzolla

Testa

Favia

et al. 2018

Special Care in Dentistry

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Langerhans cell histiocytosis (LCH) is a childhood pathology with a peak of incidence ranging from 1 to 4 years of age, though diagnosis is often made in adult age. LCH is clinically classified into three types: eosinophilic granuloma, Hand-Schuller-Christian disease and Abt-Letterer-Siwe disease. We report a case of Hand-Schüller-Christian disease with diabetes insipidus, skull and maxillary involvement in a 16-year-old boy referred to our observation for gradual increase in mobility of the teeth and subsequent gradual loss of the second premolars and the first molars of the upper jaw. Due to the extension of the lesion and the age of the patient, surgery, and chemotherapy was chosen as the more fit treatment according to the current protocol. The clinical and radiological evaluation at the end of the therapy and after 5 years showed complete remission. The absence of relapse has allowed to initiate a fixed orthodontic dental alignment treatment with a good response to orthodontic treatment despite the underlying disease. The present case exemplifies the importance of close multidisciplinary dental and medical collaboration including general dentistry, periodontology, oral medicine, oral and maxillofacial pathology, oral radiology, orthodontics and hematology-oncology for diagnosis, management, treatment monitoring, and decision-making.

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Section: Discussionmentioning

confidence: 99%

“…Other therapies include supervoltage therapy, supportive therapy, control of diabetic insipidus and surgery in specific indications …”

Section: Discussionmentioning

confidence: 99%