Histiocytosis X in an adult mimicking pyoderma gangrenosum*

Norris, J.F.B.; Marshall, T.L.; Byrne, James P.

doi:10.1111/j.1365-2230.1984.tb00822.x

Cited by 8 publications

(3 citation statements)

References 4 publications

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“…This lesion is a neutrophilic dermatosis associated with a variety of systemic diseases, such as paraproteinemia, arthritis, and myeloproliferative diseases, and IBD. In about 50% of the cases, UC is the underlying condition and PG may parallel the severity of the disease [1,9,12] . The pathogenesis of PG is poorly understood and over-expression of interleukin (IL)-8 and IL-16 has been reported, suggesting an over-reactive inflammatory response to a traumatic process.…”

Section: Discussionmentioning

confidence: 99%

“…Patients with vasculitis associated with or not associated with cr yoglobulinemia or those with antiphospholipid-antibody syndrome, and those with Wegener granulomatosis and polyartrite nodosa, may present lesions resembling PG [5,6,8,9,13] . These lesions may be misdiagnosed with PG due to initial response to steroid therapy, but without evidence of complete healing.…”

Section: Discussionmentioning

confidence: 99%

“…Many other cutaneous ulcerations resembling PG have been described in literature [6][7][8][9][10] . There has been neither laboratory finding nor histological feature diagnostic of PG, and diagnosis of PG is mainly established by exclusion criteria.…”

Section: Introductionmentioning

confidence: 99%

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Atypical presentation of pioderma gangrenosum complicating ulcerative colitis: Rapid disappearance with methylprednisolone

Aseni¹,

Sandro²,

Mihaylov³

et al. 2008

WJG

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Piodermal gangrenosum (PG) is an uncommon ulcerative cutaneous dermatosis associated with a variety of systemic diseases, including inflammatory bowel disease (IBD), arthritis, leukaemia, hepatitis, and primary biliary cirrhosis. Other cutaneous ulceration resembling PG had been described in literature. There has been neither laboratory finding nor histological feature diagnostic of PG, and diagnosis of PG is mainly made based on the exclusion criteria. We present here a patient, with ulcerative colitis (UC) who was referred to the emergency section with a large and rapidly evolving cutaneous ulceration. Laboratory and microbiological investigation associated with histological findings of the ulcer specimen allowed us to exclude autoimmune and systemic diseases as well as immuno-proliferative disorders. An atypical presentation of PG with UC was diagnosed. Pulse boluses of i.v. methyl-prednisolone were started, and after tapering steroids, complete resolution of the skin lesion was achieved in 3 wk. The unusual rapid healing of the skin ulceration with steroid mono-therapy and the atypical cutaneous presentation in this patient as well as the risk of misdiagnosis of PG in the clinical practice were discussed.

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Section: Discussionmentioning

confidence: 99%