Histo-blood group antigens as receptors for rotavirus, new understanding on rotavirus epidemiology and vaccine strategy

Jiang, Xi; Liu, Yang; Tan, Ming

doi:10.1038/emi.2017.30

Cited by 63 publications

(68 citation statements)

References 112 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Many types of viruses cause diarrhoea in animals, including TGEV (Zhang, Zhu, Zhu, Chen et al., ), swine enteric coronaviruses (SeCoVs) (Belsham et al., ), PEDV (Lohse et al., ; Tian et al., ; Zhang, Tian et al., ), porcine deltacoronavirus (Lee et al., ; Mai et al., ; Saeng‐Chuto et al., ) and rotaviruses (Kim et al., ). Rotaviruses cause acute dehydrating diarrhoea in various hosts, including children and young animals (Jiang, Liu, & Tan, ). Further information on rotavirus diversity is necessary to improve our understanding of the biological characteristics and evolution of rotaviruses.…”

Section: Discussionmentioning

confidence: 99%

A G3P[13] porcine group A rotavirus emerging in China is a reassortant and a natural recombinant in the VP4 gene

Jing

Zhang

Shi

et al. 2017

Transbound Emerg Dis

View full text Add to dashboard Cite

Group A rotaviruses (RVAs) are a major cause of serious intestinal disease in piglets. In this study, a novel pig strain was identified in a stool sample from China. The strain was designated RVA/Pig/China/LNCY/2016/G3P[13] and had a G3-P[13]-I5-R1-C1-M1-A8-N1-T1-E1-H1 genome. The viral protein 7 (VP7) and non-structural protein 4 (NSP4) genes of RVA/Pig/China/LNCY/2016/G3P[13] were closely related to cogent genes of human RVAs, suggesting that a reassortment between pig and human strains had occurred. Recombination analysis showed that RVA/Pig/China/LNCY/2016/G3P[13] is a natural recombinant strain between the P[23] and P[7] RVA strains, and crossover points for recombination were found at nucleotides (nt) 456 and 804 of the VP4 gene. Elucidating the biological characteristics of porcine rotavirus (PoRV) will be helpful for further analyses of the epidemic characteristics of this virus. The results of this study provide valuable information for RVA recombination and evolution and will facilitate future investigations into the molecular pathogenesis of RVAs.

show abstract

Section: Discussionmentioning

confidence: 99%

A G3P[13] porcine group A rotavirus emerging in China is a reassortant and a natural recombinant in the VP4 gene

Jing

Zhang

Shi

et al. 2017

Transbound Emerg Dis

View full text Add to dashboard Cite

show abstract

“…Similar human HBGAs (ABO, H, and Lewis families) are also observed in many animals, leading to shared HBGA antigens between humans and some animals [4]. These shared HBGAs may be responsible for rotavirus cross-species transmission [4,31].…”

Section: Zoonosis and Host Geneticsmentioning

confidence: 93%

The Impact of Human Genetic Polymorphisms on Rotavirus Susceptibility, Epidemiology, and Vaccine Take

Sharma

Hagbom

Svensson

et al. 2020

Viruses

View full text Add to dashboard Cite

Innate resistance to viral infections can be attributed to mutations in genes involved in the immune response, or to the receptor/ligand. A remarkable example of the latter is the recently described Mendelian trait resistance to clinically important and globally predominating genotypes of rotavirus, the most common agent of severe dehydrating gastroenteritis in children worldwide. This resistance appears to be rotavirus genotype-dependent and is mainly mediated by histo-blood group antigens (HBGAs), which function as a receptor or attachment factors on gut epithelial surfaces. HBGA synthesis is mediated by fucosyltransferases and glycosyltransferases under the genetic control of the FUT2 (secretor), FUT3 (Lewis), and ABO (H) genes on chromosome 19. Significant genotypic and phenotypic diversity of HBGA expression exists between different human populations. This genetic diversity has an effect on genotype-specific susceptibility, molecular epidemiology, and vaccine take. Here, we will discuss studies on genetic susceptibility to rotavirus infection and place them in the context of population susceptibility, rotavirus epidemiology, vaccine take, and public health impact.

show abstract

“…RV was hypothesized to have originated from a P[I] RV with a possible animal host origin and then gained the ability to infect humans by adapting to the polymorphic HBGAs in humans [45]. P [19] RVs are commonly found to infect animals (porcine) but rarely humans.…”

Section: Our Data Also Provide Clues About the Evolution Of P[ii] Rvsmentioning

confidence: 99%

Molecular basis of P[6] and P[8] major human rotavirus VP8* domain interactions with histo-blood group antigens

Yang

Tan

et al. 2019

Preprint

Self Cite

View full text Add to dashboard Cite

Initial cell attachment of rotavirus (RV) to specific cell surface glycans, which is the essential first step in RV infection, is mediated by the VP8* domain of the spike protein VP4. Recently, human histo-blood group antigens (HBGAs) have been identified as ligands or receptors for human RV strains. RV strains in the P[4] and P[8] genotypes of the P[II] genogroup share common recognition of the Lewis b and H type 1 antigens, while P[6], which is one of the other genotypes in P[II], only recognizes the H type 1 antigen. The molecular basis of receptor recognition by the major human P[8] RVs remains unknown due to lack of experimental structural information. Here, we used nuclear magnetic resonance (NMR) titration experiments and NMRderived high ambiguity driven docking (HADDOCK) methods to elucidate the molecular basis for P[8] VP8* recognition of the Le b and type 1 HBGAs and for P[6] recognition of H type 1 HBGAs. Unlike P[6] VP8* that recognizes H type 1 HGBAs in a binding surface composed of an α-helix and a β-sheet, referred as "βα binding domain", the P[8] VP8* binds the type 1 HBGAs requiring the presence of the Lewis epitope in a previously undescribed pocket formed by two β-sheets, referred as "β binding domain". The observation that P[6] and P[8] VP8* domains recognize different glycan structures at distinct binding sites supports the hypothesis that RV evolution is driven, at least in part, by selective pressure driven adaptation to HBGA structural diversity of their natural hosts living in the world. Recognition of the role that HBGAs play in driving RV evolution is essential to understanding RV diversity, host ranges, disease burden and zoonosis and to developing strategies to improve vaccines against RV infections.

show abstract

Histo-blood group antigens as receptors for rotavirus, new understanding on rotavirus epidemiology and vaccine strategy

Cited by 63 publications

References 112 publications

A G3P[13] porcine group A rotavirus emerging in China is a reassortant and a natural recombinant in the VP4 gene

A G3P[13] porcine group A rotavirus emerging in China is a reassortant and a natural recombinant in the VP4 gene

The Impact of Human Genetic Polymorphisms on Rotavirus Susceptibility, Epidemiology, and Vaccine Take

Molecular basis of P[6] and P[8] major human rotavirus VP8* domain interactions with histo-blood group antigens

Contact Info

Product

Resources

About