Histo-Blood Group Carbohydrates and Helicobacter pylori Infection

Mattos, Luiz Carlos de

doi:10.4172/2155-9597.1000140

Cited by 2 publications

(2 citation statements)

References 14 publications

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“…This simplifies the calibration of p 2 in the DRR into determining the proportion of the population which is resistant, an application to which genomics approaches are particularly well suited. However, the possibility that the pathogen could use alternative receptors would need to be eliminated, as in the case of the bacterium H. pylori , which is known to use other carbohydrate receptors in addition to HBGA (De Mattos ) such that p 2 is the sum of probabilities of parallel routes, each with a different p value.…”

Section: An Omics‐based Approach For Estimating the Probability Of Inmentioning

confidence: 99%

Applications of omics approaches to the development of microbiological risk assessment using RNA virus dose-response models as a case study

et al. 2014

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SummaryThe last decade has seen a huge increase in the amount of 'omics' data available and in our ability to interpret those data. The aim of this paper was to consider how omics techniques can be used to improve and refine microbiological risk assessment, using dose-response models for RNA viruses, with particular reference to norovirus through the oral route as the case study. The dose-response model for initial infection in the gastrointestinal tract is broken down into the component steps at the molecular level and the feasibility of assigning probabilities to each step assessed. The molecular mechanisms are not sufficiently well understood at present to enable quantitative estimation of probabilities on the basis of omics data. At present, the great strength of gene sequence data appears to be in giving information on the distribution and proportion of susceptible genotypes (for example due to the presence of the appropriate pathogen-binding receptor) in the host population rather than in predicting specificities from the amino acid sequences concurrently obtained. The nature of the mutant spectrum in RNA viruses greatly complicates the application of omics approaches to the development of mechanistic dose-response models and prevents prediction of risks of disease progression (given infection has occurred) at the level of the individual host. However, molecular markers in the host and virus may enable more broad predictions to be made about the consequences of exposure in a population. In an alternative approach, comparing the results of deep sequencing of RNA viruses in the faeces/vomitus from donor humans with those from their infected recipients may enable direct estimates of the average probability of infection per virion to be made.

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Section: An Omics‐based Approach For Estimating the Probability Of Inmentioning

confidence: 99%

Applications of omics approaches to the development of microbiological risk assessment using RNA virus dose-response models as a case study

et al. 2014

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“…Trichinella spiralis (Owen, 1835) is the only species usually found in porcine, and some wild animals (e.g, boar, bear, carnivores, rodents). T. spiralis can be transmitted and maintained in both a domestic and sylvatic cycle whereby rats, among others contribute to the spread of T. spiralis from domestic to sylvatic animals and vice versa (Pozio, 2007;Farina et al, 2012). The only means of transmission is through the ingestion of infected, striated muscle tissue.…”

Section: Introductionmentioning

confidence: 99%

The viability of Trichinella spiralis larvae in frozen pork and wild boar meat revealed by the experimental infection of laboratory mice

Iacob¹

2015

Helminthologia

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SummaryThe aim of the research was to verify the viability of Trichinella spiralis larvae in pig and wild boar meat frozen at -18 °C from 268 days to 1021 days. There were three groups of laboratory inbred Balb/C mice and Bagg/ Albino/ strain C, each group received one sample consisting of 20 g meat infected with T. spiralis larvae, according to the protocol, and an uninfected control group. The experiments were ended after 80 days, by euthanizing the mice and taking samples of muscle tissue, which were processed for histopathology. The results revealed the presence of Trichinella cysts in all experimental groups, confi rming the extraordinary durability and viability of Trichinella larvae in meat frozen at -18 °C for many months. It was confi rmed that the larvae detected in muscle tissues of mice were Trichinella spiralis.

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Histo-Blood Group Carbohydrates and Helicobacter pylori Infection

Cited by 2 publications

References 14 publications

Applications of omics approaches to the development of microbiological risk assessment using RNA virus dose-response models as a case study

Applications of omics approaches to the development of microbiological risk assessment using RNA virus dose-response models as a case study

The viability of Trichinella spiralis larvae in frozen pork and wild boar meat revealed by the experimental infection of laboratory mice

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