Histo-epidemiological profile of breast cancers among women in the Central African Republic: about 174 cases

Balekouzou, Augustin; Yin, Ping; Bekolo, Cavin Epie; Pamatika, Christian Maucler; Djeintote, Marceline; Nambei, Sylvain Wilfrid; Ba-Mpoutou, Bertrand; Mandjiza, Dieubeni Rawago; Shu, Chang; Yin, Ming; Qing, Tingting; Koffi, B.

doi:10.1186/s12885-018-4256-2

Cited by 9 publications

(16 citation statements)

References 17 publications

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“…The relatively young age of women with BC and the predominance of advanced tumor stages were reported in several studies in SSA [19,[37][38][39][40][41][42][43]. In Western countries the majority of BC patients present when they are still at a early stage, with a mean age greater than 60 years old, more than 10 years older than in African countries [44,45].…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Histological Characteristics of Breast Cancer in Rwanda in Relation to Age and Tumor Stages

et al. 2020

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Breast cancer is a complex disease, and it is the most common cause of morbidity and mortality among women worldwide. In Sub-Saharan Africa, the clinical characteristics and tumor profiles of breast cancer are still unknown. In the present study we aimed to determine breast tumor profiles of the Rwandan patients in relation to age and tumor stages. We compare our findings to related results from other sub-Saharan Africa studies. Data on age at diagnosis, tumor stage, and hormonal profiles of 138 patients diagnosed between January 2015 and December 2018 were retrospectively retrieved from electronic medical records at three referral hospitals in Rwanda. We compared our results to related findings reported in other Sub-Saharan African countries. All statistical analyses were done using SPSS Inc., Chicago, IL, USA, version 20 and R software languages. The mean age at diagnosis was 49.7 years (SD = 13) and ranged from 17 to 86 years. The majority of patients (57.2%) were diagnosed before 50 years of age compared with 42.8% aged > 50 years. Tumor stage III was the commonest accounting for 62% followed by stage II with 24.8%. The distribution of breast tumor subtypes was ER−

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Section: Discussionmentioning

confidence: 99%

Prevalence of Histological Characteristics of Breast Cancer in Rwanda in Relation to Age and Tumor Stages

et al. 2020

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“…In Congo, it is the first of all cancers according to the latest estimates from GLOBOCAN 2020 [5] . There is a variable distribution from region to region of incidence rates around the world [6] . Breast cancer incidence rates are rising rapidly in the transition countries of South America, Africa and Asia as well as high-income Asian countries (Japan and the Republic of Korea) where rates are historically low [5] .…”

Section: Introductionmentioning

confidence: 99%

Breast Cancer in Women: Epidemiological, Histological, Immunohistochemical and Molecular Sub-Types in the Republic of Congo

Malanda

Boumba

Malonga

2021

Int J Health Sci Res

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Introduction: Breast cancer is a heterogeneous disease with a variety of morphological, molecular, treatment response and clinical outcome characteristics. The objective of this work was to assess the epidemiological, histological, immunohistochemical and molecular subtypes of breast cancer in women in the Republic of Congo. Material and Methods: We carried out a cross-sectional descriptive study which took place from January 1, 2014 to December 31, 2020. The study focused on 150 cases of breast cancer in patients diagnosed at the University Hospital of Brazzaville (CHU-B). The epidemiological, clinical, histological, immunohistochemical and molecular subtypes were the variables studied. Results: The mean age was 48.09 ± 13.87 years with the extremes of 22 years and 80 years. The study of the profession; the most represented in our study was that of the cultivator 20.67%. A predominance of breast cancer localization was observed in the left breast in 47.33%. The frequency of a family history was 7.33% or 11 cases. The most frequently represented histologic type was 62% invasive non-specific type carcinoma (CITNS). The most represented histological grade was Scarff Bloom Richardson grade II (51.33%), followed by grade III 24% and grade I in 12% of cases. Regarding the results of IHC; of the 150 cases, 102 (68%) had positive hormone receptors (HR +). The ORs were positive in 102 cases (68%) while the PRs were positive in 98 cases (65.33%). The Her2 oncogene was over expressed in 38 cases (25.3%). The Ki-67 proliferation index was known for the 150 cases, including 77 (51.33%) less than 15% and 73 (48.67%) greater than or equal to 15%. The distribution of molecular subtypes was 46% luminal A, 22% triple negative, 17% luminal B and 10% Her2 +. Tumors of unknown molecular profile were 5%. The correlation was found between molecular subtype and histological type. This result was statistically significant (p <0.05). For the rest. There was no correlation between age and SBR grade (p> 0.05). The correlation was found between molecular subtype and histological type. This result was statistically significant (p <0.05). For the rest. There was no correlation between age and SBR grade (p> 0.05). The correlation was found between molecular subtype and histological type. This result was statistically significant (p <0.05). For the rest. There was no correlation between age and SBR grade (p> 0.05). Conclusion: It should be noted that the association between histological and immunohistochemical diagnosis can help determine the phenotype of breast cancer, with the aim of guiding treatment and therefore improving response to treatment. Key words: Epidemiology, Histology, Immunohistochemistry, molecular subtypes, breast cancer, Republic of Congo.

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“…We also found studies conducted in Ghana ( n = 6) ( 50 , 71 , 111 , 123 , 134 , 155 ), Kenya ( n = 5) ( 70 , 96 , 115 , 132 , 139 ), Zambia ( n = 4) ( 44 , 77 , 102 , 126 ), and Eritrea ( n = 3) ( 60 – 62 ). There were seven countries with two studies each [Botswana ( 43 , 47 ), the Central African Republic ( 31 , 32 ), Mozambique ( 57 , 58 ), Rwanda ( 130 , 136 ), Senegal ( 147 , 156 ), Sudan ( 84 , 114 ) and Zimbabwe ( 38 , 39 )]. The countries with a single study were Cote d'Ivoire ( 128 ), Democratic Republic of Congo ( 99 ), Mali ( 85 ), Swaziland ( 76 ), Tanzania ( 49 ), and The Gambia ( 30 ).…”

Section: Resultsmentioning

confidence: 99%

“…There was one incidence study from each of the following countries: a retrospective record review of registry in Nigeria ( 24 ), The Gambia ( 30 ), the Central African Republic ( 31 ), Eritrea ( 62 ), Malawi ( 37 ), Zimbabwe ( 38 ), Mali ( 85 ), and Sudan ( 84 ).…”

Section: Resultsmentioning

confidence: 99%

Mapping Evidence on the Burden of Breast, Cervical, and Prostate Cancers in Sub-Saharan Africa: A Scoping Review

Musekiwa

Moyo²,

Mohammed³

et al. 2022

Front. Public Health

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BackgroundCancer remains a major public health problem, especially in Sub-Saharan Africa (SSA) where the provision of health care is poor. This scoping review mapped evidence in the literature regarding the burden of cervical, breast and prostate cancers in SSA.MethodsWe conducted this scoping review using the Arksey and O'Malley framework, with five steps: identifying the research question; searching for relevant studies; selecting studies; charting the data; and collating, summarizing, and reporting the data. We performed all the steps independently and resolved disagreements through discussion. We used Endnote software to manage references and the Rayyan software to screen studies.ResultsWe found 138 studies that met our inclusion criteria from 2,751 studies identified through the electronic databases. The majority were retrospective studies of mostly registries and patient files (n = 77, 55.8%), followed by cross-sectional studies (n = 51, 36.9%). We included studies published from 1990 to 2021, with a sharp increase from 2010 to 2021. The quality of studies was overall satisfactory. Most studies were done in South Africa (n = 20) and Nigeria (n = 17). The majority were on cervical cancer (n = 93, 67.4%), followed by breast cancer (67, 48.6%) and the least were on prostate cancer (48, 34.8%). Concerning the burden of cancer, most reported prevalence and incidence. We also found a few studies investigating mortality, disability-adjusted life years (DALYs), and years of life lost (YLL).ConclusionsWe found many retrospective record review cross-sectional studies, mainly in South Africa and Nigeria, reporting the prevalence and incidence of cervical, breast and prostate cancer in SSA. There were a few systematic and scoping reviews. There is a scarcity of cervical, breast and prostate cancer burden studies in several SSA countries. The findings in this study can inform policy on improving the public health systems and therefore reduce cancer incidence and mortality in SSA.

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Histo-epidemiological profile of breast cancers among women in the Central African Republic: about 174 cases

Cited by 9 publications

References 17 publications

Prevalence of Histological Characteristics of Breast Cancer in Rwanda in Relation to Age and Tumor Stages

Prevalence of Histological Characteristics of Breast Cancer in Rwanda in Relation to Age and Tumor Stages

Breast Cancer in Women: Epidemiological, Histological, Immunohistochemical and Molecular Sub-Types in the Republic of Congo

Mapping Evidence on the Burden of Breast, Cervical, and Prostate Cancers in Sub-Saharan Africa: A Scoping Review

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