Histochemical and immunohistochemical analyses of the myocardial scar fallowing acute myocardial infarction

Tatić, Vujadin; Rafajlovski, Saso; Kanjuh, Vladimir; Gajanin, Radoslav; Suscevic, Dusan; Balint, Bela; Obradović, Slobodan

doi:10.2298/vsp110110008t

Cited by 4 publications

(3 citation statements)

References 27 publications

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“…Thereafter, the infarcted areas are replaced by collagen-rich scars because of the limited regeneration ability of cardiomyocytes. [ 66 ] The scar was thought to be the production of resident myofibroblasts. [ 67 ] This paradigm is now challenged by many reports.…”

Section: Irculating F Ibrocytes In mentioning

confidence: 99%

Role of Circulating Fibrocytes in Cardiac Fibrosis

Lin

Liang

et al. 2016

Chinese Medical Journal

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Objective:It is revealed that circulating fibrocytes are elevated in patients/animals with cardiac fibrosis, and this review aims to provide an introduction to circulating fibrocytes and their role in cardiac fibrosis.Data Sources:This review is based on the data from 1994 to present obtained from PubMed. The search terms were “circulating fibrocytes” and “cardiac fibrosis”.Study Selection:Articles and critical reviews, which are related to circulating fibrocytes and cardiac fibrosis, were selected.Results:Circulating fibrocytes, which are derived from hematopoietic stem cells, represent a subset of peripheral blood mononuclear cells exhibiting mixed morphological and molecular characteristics of hematopoietic and mesenchymal cells (CD34+/CD45+/collagen I+). They can produce extracellular matrix and many cytokines. It is shown that circulating fibrocytes participate in many fibrotic diseases, including cardiac fibrosis. Evidence accumulated in recent years shows that aging individuals and patients with hypertension, heart failure, coronary heart disease, and atrial fibrillation have more circulating fibrocytes in peripheral blood and/or heart tissue, and this elevation of circulating fibrocytes is correlated with the degree of fibrosis in the hearts.Conclusions:Circulating fibrocytes are effector cells in cardiac fibrosis.

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Section: Irculating F Ibrocytes In mentioning

confidence: 99%

Role of Circulating Fibrocytes in Cardiac Fibrosis

Lin

Liang

et al. 2016

Chinese Medical Journal

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“…Recently, Tatìc et al [179], investigated the histological, histochemical and immunohistochemical findings in cardiac samples taken from 177 patients who had died of acute myocardial MI. Interestingly, in the scar, a large number of cells of various size and form (spindle, oval, elongated with abundant cytoplasm, small with one nucleus and cells with scanty cytoplasm) were found.…”

Section: Proliferative Phasementioning

confidence: 99%

The Meaning of Different Forms of Structural Myocardial Injury, Immune Response and Timing of Infarct Necrosis and Cardiac Repair

Turillazzi

Pomara

Bello

et al. 2015

CVP

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Although a decline in the all-cause and cardiac mortality rates following myocardial infarction (MI) during the past 3 decades has been reported, MI is a major cause of death and disability worldwide. From a pathological point of view MI consists in a particular myocardial cell death due to prolonged ischemia. After the onset of myocardial ischemia, cell death is not immediate, but takes a finite period of time to develop. Once complete myocytes' necrosis has occurred, a process leading to a healed infarction takes place. In fact, MI is a dynamic process that begins with the transition from reversible to irreversible ischemic injury and culminates in the replacement of dead myocardium by a fibrous scar. The pathobiological mechanisms underlying this process are very complex, involving an inflammatory response by several pathways, and pose a major challenge to ability to improve our knowledge. An improved understanding of the pathobiology of cardiac repair after MI and further studies of its underlying mechanisms provide avenues for the development of future strategies directed toward the identification of novel therapies. The chronologic dating of MI is of great importance both to clinical and forensic investigation, that is, the ability to create a theoretical timeline upon which either clinicians or forensic pathologists may increase their ability to estimate the time of MI. Aging of MI has very important practical implications in clinical practice since, based on the chronological dating of MI, attractive alternatives to solve therapeutic strategies in the various phases of MI are developing.

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“…Imunohistokemijski se dokazuje aktin, mioglobin, fibronektin, komponente komplementa, marker stanične proliferacije (PCNA) te izričaj srčanog troponina C (cTnC) koji je izrazito eksprimiran u svježem infarktu miokarda 20,21 . Unatoč mogućnostima primjene imunohistokemijskih metoda PHA-a, HE bojenje ostaje zlatni standard zbog svoje relativne točnosti i ekonomičnosti, a u slučaju da se primjenjuju druge metode HE im mora prethoditi 22 .…”

Section: Imunohistokemijskeunclassified

Medicolegal application of a simple histopathological analysis

et al. 2018

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Sažetak. Cilj: Cilj studije ukazati je na ulogu patohistološke analize (PHA) preparata tkiva bojenih hemalaun-eozin (HE) bojom u sudskomedicinskoj praksi. Metode: Radi se o retrospektivnoj studiji obdukcija izvršenih na Zavodu za sudsku medicinu i kriminalistiku Medicinskog fakulteta u Rijeci u periodu od 2000. do 2014. Istražena je zastupljenost prirodnih prema nasilnim smrtima te vrsta prirodnih smrti koje su kod sudskomedicinskih obdukcija najzastupljenije. Također ćemo prikazati koji udio u srčanim smrtima čine smrti zbog ishemijske bolesti srca (IBS) te koliki je udio preminulih od infarkta miokarda (IM). Rezultati: Temeljem analiziranih podataka proizlazi da se u istraživanom petnaestogodišnjem periodu odnos između nasilnih i prirodnih smrti nije značajnije mijenjao (p = 0,052) te je tijekom tog razdoblja broj obdukcija relativno konstantan. Uočen je trend porasta prirodnih u odnosu na nasilne smrti od 2010. godine. Kod prirodnih, srčane smrti su vodeći uzrok, a udio smrti uslijed ishemijske bolesti srca (IBS) u tim srčanim smrtima iznosi 87 %. Od ukupnih smrti uslijed IBS-a u provedenom istraživanju IM je zastupljen s 21 %. Zaključak: Patohistološka analiza neizostavna je kod naglih srčanih smrti (NSS) u koje, kao smrt uslijed IBS-a, spada i IM. To je pretraga koja pomaže kada na obdukciji nije moguće utvrditi stvaran uzrok smrti; pretraga koja omogućava vizualizaciju infarktom zahvaćenog srčanog mišića i unutar 24 sata od nastanka lezije (što se ne može uočiti makroskopski) te u sudskom postupku može otkloniti dvojbe. Osim što može potvrditi makroskopski nalaz s obdukcije, može katkad biti pretraga koja utvrđuje stvarni uzrok smrti, a kod naglih srčanih smrti ta je pretraga neizostavna. Predstavlja materijal koji se može koristiti za pregled duže vrijeme nakon smrti, za znanstvena istraživanja i edukaciju.

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Histochemical and immunohistochemical analyses of the myocardial scar fallowing acute myocardial infarction

Abstract: Our findings speak that myocardial regeneration is maybe possible and develops in human ischemic heart damages and that the myocardium is not a static organ without capacity of cell regeneration.

Cited by 4 publications

References 27 publications

Role of Circulating Fibrocytes in Cardiac Fibrosis

Role of Circulating Fibrocytes in Cardiac Fibrosis

The Meaning of Different Forms of Structural Myocardial Injury, Immune Response and Timing of Infarct Necrosis and Cardiac Repair

Medicolegal application of a simple histopathological analysis

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