Histochemical and Pharmacological Approach to the Investigation of Neurotransmitters, with Particular Regard to the Cerebrovascular Bed

Owman, Christer; Edvinsson, Lars

doi:10.1002/9780470720370.ch15

Cited by 13 publications

(1 citation statement)

References 54 publications

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“…Microscopic and functional studies have revealed that NPY expression becomes prominent with the increase of sympathetic activity [64]. Furthermore, it has been proven that NA modulates the response of the small pial vessels on the cortical surface and that sympathetic fibers arise from central sources such as locus coeruleus (LC) or the hypothalamus [65][66][67]. Therefore, via direct influence, destruction of the LC induces a reduction in the number of noradrenergic nerve fibers in intracerebral vessels [59], while on contrary that stimulation of NA neurons in the hypothalamus is associated with an increase in hypothalamic blood flow which is not influenced by superior cervical ganglionectomy or by the β-adrenoceptor antagonist propranolol [68].…”

Section: Sympathetic Nervous System and Headachementioning

confidence: 99%

Primary Headaches and their Relationship with the Autonomic Nervous System

Iulian¹,

Irina²,

Victor³

et al. 2017

Current Perspectives on Less-Known Aspects of Headache

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Headache disorders, described as early as 3000 BC, represent both a treatment challenge and a serious public health concern, with impact on the individual and society. Existing research in primary headache syndromes (not being caused by any underlying problem) focuses mainly on pain mechanisms. However, the painful symptomatology is the main encounter for the decreased quality of life and discomfort, the vegetative manifestations that frequently accompany the cephalalgic syndromes represent an important source of distress. Despite the advancement of the understanding of the molecular basis of headache disorders and neurovascular complex interactions, there is still lack of a cohesive understanding of the neurovegetative modulation in different types of primary cephalalgic syndromes. The aim of this chapter is to present an overview of the neurochemical mechanisms and pathways, which subtend dysautonomic manifestations in headache.

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Section: Sympathetic Nervous System and Headachementioning

confidence: 99%

Primary Headaches and their Relationship with the Autonomic Nervous System

Iulian¹,

Irina²,

Victor³

et al. 2017

Current Perspectives on Less-Known Aspects of Headache

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Increased density of perivascular adrenergic innervation in tibial and vagus nerves of spontaneously hypertensive rats

Koistinaho

Wadhwani

Rapoport

1989

J of Neuroscience Research

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Adrenergic innervation of epiperineurial arterioles and of the endoneurium of the tibial and vagus nerves of spontaneously hypertensive rats (SHR) and normotensive controls (WKY) was studied by glyoxylic acid-induced fluorescence and paraformaldehyde-induced fluorescence methods. Adrenergic perivascular innervation of epiperineurial arterioles in both nerves was denser in SHR than in controls. Mean density in the endoneurium also was higher in SHR in both nerve types. These results suggest that adrenergic perivascular innervation, which may influence nerve blood flow, becomes greater in density in peripheral nerves during chronic hypertension.

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Effect of Topically Administered Epinephrine, Norepinephrine and Acetylcholine on Cerebrocortical Vascular Volume and NAD/NADH Redox State

Dóra

1983

The Cerebral Veins

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Histochemical and Pharmacological Approach to the Investigation of Neurotransmitters, with Particular Regard to the Cerebrovascular Bed

Cited by 13 publications

References 54 publications

Primary Headaches and their Relationship with the Autonomic Nervous System

Primary Headaches and their Relationship with the Autonomic Nervous System

Increased density of perivascular adrenergic innervation in tibial and vagus nerves of spontaneously hypertensive rats

Effect of Topically Administered Epinephrine, Norepinephrine and Acetylcholine on Cerebrocortical Vascular Volume and NAD/NADH Redox State

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