Histochemical and ultrastructural study of human muscles after spontaneous rupture of the tendon

Józsa, László; Bálint, J; S, Demel

doi:10.1016/s0065-1281(78)80008-7

Acta Histochemica

1978

DOI: 10.1016/s0065-1281(78)80008-7

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Histochemical and ultrastructural study of human muscles after spontaneous rupture of the tendon

László Józsa¹,

J Bálint²,

Demel S³

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Cited by 7 publications

(2 citation statements)

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“…Therefore, longitudinal atrophy first requires disruption of the structural anchors (i.e., the costameres) by specific Ca 2+ ‐activated proteases12 to release the respective sarcomeres. In fact, Z‐line streaming is observed after tendon release in the rat13 and after spontaneous tendon tears in various human muscles 14…”

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confidence: 99%

“…In fact, Z-line streaming is observed after tendon release in the rat 13 and after spontaneous tendon tears in various human muscles. 14 The main regulator of costamere turnover is focal adhesion kinase (FAK), an integrin-associated phosphotransfer kinase that is activated by phosphorylation on its tyrosine 397 site (pY397). It is mechanosensitive and reacts to altered loading of the muscle.…”

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Costamere protein expression and tissue composition of rotator cuff muscle after tendon release in sheep

Ruoss

Möhl

Benn

et al. 2017

Journal Orthopaedic Research

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Previous studies suggested that degradation of contractile tissue requires cleavage of the costamere, a structural protein complex that holds sarcomeres in place. This study examined if costamere turnover is affected by a rotator cuff tear in a previously established ovine model. We found the activity of focal adhesion kinase (FAK), a main regulator of costamere turnover, was unchanged at 2 weeks but decreased by 27% 16 weeks after surgical release of the infraspinatus tendon. This was accompanied by cleavage of the costamere protein talin into a 190 kDa fragment while full length talin remained unchanged. At 2 weeks after tendon release, muscle volume decreased by 17 cm3 from an initial 185 cm3, the fatty tissue volume was halved, and the contractile tissue volume remained unchanged. After 16 weeks, the muscle volume decreased by 36 cm3, contractile tissue was quantitatively lost, and the fat content increased by 184%. Nandrolone administration mitigated the loss of contractile tissue by 26% and prevented fat accumulation, alterations in FAK activity, and talin cleavage. Taken together, these findings imply that muscle remodeling after tendon release occurs in two stages. The early decrease of muscle volume is associated with reduction of fat; while, the second stage is characterized by substantial loss of contractile tissue accompanied by massive fat accumulation. Regulation of costamere turnover is associated with the loss of contractile tissue and seems to be impacted by nandrolone treatment. Clinically, the costamere may represent a potential intervention target to mitigate muscle loss after a rotator cuff tear. © 2017 The Authors. Journal of Orthopaedic Research® published by Wiley Periodicals, Inc. on behalf of the Orthopaedic Research Society. J Orthop Res 36:272–281, 2018.

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confidence: 99%

mentioning

confidence: 99%

Costamere protein expression and tissue composition of rotator cuff muscle after tendon release in sheep

Ruoss

Möhl

Benn

et al. 2017

Journal Orthopaedic Research

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Skeletal muscle response to tenotomy

et al. 2000

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Capillary density of tenotomized skeletal muscles

Józsa¹,

Järvinen

Kvist

et al. 1980

Europ. J. Appl. Physiol.

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Our purpose was to study the capillary density of rat gastrocnemius muscle by microangiography 7-21 days after achillotenotomy or immobilization in a plaster cast. Sixteen animals were tenotomized, 12 immobilized in a plaster cast, and 4 served as controls. The number of capillaries was counted per 1,000 muscle fibres from each sample. No site differences were found in control muscles, where on an average 1,250 capillaries per 1,000 muscle fibers were found. After tenotomy the number of capillaries was decreased 35%, 31%, and 32% on days 7, 14, and 21, respectively. In immobilized muscles the decrease in capillary density occurred slowly, the corresponding decrease being 23%, 33%, and 28% on days 7, 14, and 21, respectively. These results indicate that the capillary density of muscular tissue is greatly decreased following the disuse produced by tenotomy or immobilization.

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Histochemical and ultrastructural study of human muscles after spontaneous rupture of the tendon

Cited by 7 publications

References 10 publications

Costamere protein expression and tissue composition of rotator cuff muscle after tendon release in sheep

Costamere protein expression and tissue composition of rotator cuff muscle after tendon release in sheep

Skeletal muscle response to tenotomy

Capillary density of tenotomized skeletal muscles

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