Histochemical changes in innervated and denervated skeletal muscle fibers following treatment with bupivacaine (marcain)

Hall-Craggs, E. C. B.; Seyan, H. S.

doi:10.1016/0014-4886(75)90140-5

Cited by 53 publications

(20 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On muscle cross-sections, newly formed myofibers can be readily distinguished by their small caliber and centrally located myonuclei. These myofibers are often basophilic in the beginning of regeneration due to protein synthesis and the expression of embryonic/developmental forms of MyHC (217,562). On muscle longitudinal sections and on isolated single myofibers, the centrally localized myonuclei were observed in discrete segments of regenerating myofibers or along the entire new myofiber, which suggests that cell fusion during regeneration happens in a focal, rather than diffuse, manner (58).…”

Section: /Cd163mentioning

confidence: 99%

Satellite Cells and the Muscle Stem Cell Niche

Yin

Price

Rudnicki

2013

Physiological Reviews

1,763

1,808

View full text Add to dashboard Cite

LYin H, Price F, Rudnicki MA. Satellite Cells and the Muscle Stem Cell Niche. Physiol Rev 93: 23-67, 2013; doi:10.1152/physrev.00043.2011.-Adult skeletal muscle in mammals is a stable tissue under normal circumstances but has remarkable ability to repair after injury. Skeletal muscle regeneration is a highly orchestrated process involving the activation of various cellular and molecular responses. As skeletal muscle stem cells, satellite cells play an indispensible role in this process. The self-renewing proliferation of satellite cells not only maintains the stem cell population but also provides numerous myogenic cells, which proliferate, differentiate, fuse, and lead to new myofiber formation and reconstitution of a functional contractile apparatus. The complex behavior of satellite cells during skeletal muscle regeneration is tightly regulated through the dynamic interplay between intrinsic factors within satellite cells and extrinsic factors constituting the muscle stem cell niche/microenvironment. For the last half century, the advance of molecular biology, cell biology, and genetics has greatly improved our understanding of skeletal muscle biology. Here, we review some recent advances, with focuses on functions of satellite cells and their niche during the process of skeletal muscle regeneration.

show abstract

Section: /Cd163mentioning

confidence: 99%

Satellite Cells and the Muscle Stem Cell Niche

Yin

Price

Rudnicki

2013

Physiological Reviews

1,763

1,808

View full text Add to dashboard Cite

show abstract

“…Local anesthetics, usually used to reversibly block nerve conduction, may also affect a variety of non-neuronal processes: excitation-contraction coupling in muscles (Bianchi and Bolton 1967;Suko et al 1976;NashAdler et al 1980;Wolosker et al 1992), uncoupling of mitochondrial oxidative phosphorylation (Moseley and Sisso 1972;Dabadie et al 1987;Sztark et al 1997), inhibition of Ca 2+ -calmodulin-dependent enzymes (Tanaka and Hidaka 1981;Volpi et al 1981), inhibition of histamine release from mast cells (Kazimierczak et al 1976), inhibition of Ca 2+ -Mg 2+ -ATPase activity in brain synaptosomes (García-Martín and Gutiérrez-Merino 1986), increase in the membrane permeability to Ca 2+ and Mg 2+ (Low et al 1979;Escudero and Gutiérrez-Merino 1987); they also promote histochemical changes in skeletal muscle (Hall-Craggs 1974;Hall-Craggs and Seyan 1975) and cause injuries in corneal epithelia (Grant and Acosta 1994), among other effects (Ohki 1984;Ragsdale et al 1994;Takahashi 1994;Fujita et al 1998).…”

Section: Introductionmentioning

confidence: 94%

Effect of carticaine on the sarcoplasmic reticulum Ca 2+ -dependent adenosine triphosphatase

Takara

Sánchez

Alonso

2000

Naunyn-Schmiedeberg's Archives of Pharmacology

View full text Add to dashboard Cite

The sarcoplasmic reticulum Ca2+-ATPase (calcium-dependent adenosine triphosphatase) transports Ca2+ from the myoplasm to the reticulum lumen at the expense of free energy from ATP hydrolysis. Carticaine is a local anesthetic of frequent use in dentistry which is now entering other clinical fields. We studied the action of carticaine on the sarcoplasmic reticulum (SR) skeletal muscle Ca2+-ATPase. SR vesicles from rabbit fast skeletal muscle were used. Carticaine inhibits the enzymatic activity. The inhibition of the enzymatic activity depends on pH, [Ca2+] and the presence of calcimycin. Half-maximal carticaine concentration that inhibits the ATPase activity tends to a maximal value upon increasing [Ca2+]. Carticaine concentrations required to inhibit the enzymatic activity at myoplasmic calcium concentration are lower than usual clinical doses: Ki=6.0+/-1.4 mM carticaine (n=5) for 0.1 microM [Ca2+]. ATP-dependent calcium uptake is also inhibited by the local anesthetic: Ki=30.5+/-3.4 mM (n=4). Besides, carticaine inhibits the phosphorylation of the enzyme by inorganic phosphate (Pi): Ki=20.0+/-3.4 (n=5) - 33.2+/-4.6 (n=4) mM, for [Pi] 1-4 mM. Carticaine increases the membrane permeability to Ca2+. Ca2+ efflux from preloaded vesicles is prevented by Ca2+ and Mg2+. Our results suggest that the diffusion of the local anesthetic into muscle fibers might trigger undesired effects such as sustained contraction of the masticatory muscles.

show abstract

“…Other authors (Sokoll et al, 1968;Benoit & Belt, 1970;Libelius, Sonesson, Stamenovic & Theslef, 1970) have reported degeneration in the superficial parts of muscles when the same dose was administered into the subcutaneous space. In these cases the intramuscular concentration is not derivable but probably would have been lower than the level of 1 mg cm-3 that resulted from direct intramuscular injection (Hall-Craggs & Singh Seyan, 1975). It can be concluded therefore that provided the maximum permitted dose is not exceeded, bupivacaine probably does not cause muscle degeneration when used as a regional intravenous anaesthetic.…”

Section: Discussionmentioning

confidence: 97%

“…The dose of 150mg bupivacaine was therefore distributed in the soft tissues at a concentration of 0.8 mg cm-3 which was far lower than the level of 3 mg cm-3 in the rat calf muscles (mean volume in 10 animals was 5 cm3). However, local degeneration has been demonstrated histologically in the soleus muscle following the intramuscular injection of only 2.5 mg bupivacaine (Hall-Craggs & Singh Seyan, 1975) which would have resulted in a muscle concentration of approximately 1 mg cm-3. Other authors (Sokoll et al, 1968;Benoit & Belt, 1970;Libelius, Sonesson, Stamenovic & Theslef, 1970) have reported degeneration in the superficial parts of muscles when the same dose was administered into the subcutaneous space.…”

Section: Discussionmentioning

confidence: 99%