Histochemical Demonstration of Monoamines in the Thymus of Rats

Fujiwara, Motohatsu; Muryobayashi, Takashi; Shimamoto, Kiro

doi:10.1254/jjp.16.493

Cited by 14 publications

(1 citation statement)

References 6 publications

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“…The central dopaminergic system appears to exert a net stimulatory influence over the immune system, a conclusion which is based on changes in the immune system of patients suffering from such neurological diseases as Parkinsonism (Fujiwara et al, 1966).…”

Section: Dopaminementioning

confidence: 99%

Stress and the Immune System: Immunological Aspects of Depressive Illness

Leonard

1990

International Review of Psychiatry

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Anecdotal evidence suggesting a causal relationship between psychiatric illness, environmental stress and a malfunctioning immune system goes back to antiquity. Recently, clinical and experimental studies have established the inter-relationship between neuroendocrine regulation, the immune system and abnormalities in central neurotransmission which may be deranged as a consequence of stressful events. This short review is an attempt to assess the evidence implicating altered immune responsiveness in depression and to consider the impact of dtferent types of environmental stress in triggering the immune malfunction. While these findings are of considerable biological importance, it is presently unclear whether the immunological changes are primary or secondary to the disease states.Int Rev Psychiatry Downloaded from informahealthcare.com by Monash University on 11/26/14 For personal use only. Int Rev Psychiatry Downloaded from informahealthcare.com by Monash University on 11/26/14 For personal use only.

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Section: Dopaminementioning

confidence: 99%

Stress and the Immune System: Immunological Aspects of Depressive Illness

Leonard

1990

International Review of Psychiatry

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Sympathetic innervation of murine thymus and spleen: A comparative histofluorescence study

1981

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Fluorescence microscopy of thymus and spleen from four strains of mice (C3H and ICR controls, AKR spontaneously leukemic and NZB autoimmune) revealed varicose noradrenergic (NE) fibers in perivascular and parenchymal regions of both organs. Thymic innervation was largely perivascular, but isolated islands and strings of free NE fibers were noted among thymic parenchymal cells. A morphological proximity between NE fibers in the thymus and mast cells was noted in all strains studied, but was exceptionally prominent in the NZB thymus. Perivascular plexuses within the splenic white pulp sent single NE fibers between the surrounding lymphocytes. Catecholamines and histamine have been shown to modulate lymphocyte development and activity in vitro. The present study provides morphological evidence that both NE and histamine are available to lymphocytes in thymus and spleen, and thus provides morphological evidence for neural modulation of immune activity in vivo.

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Effects on the Immune System of Lesioning and Stimulation of the Nervous System: Neuroimmunomodulation

Janković¹,

Spector

1986

Enkephalins and Endorphins

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Histochemical Demonstration of Monoamines in the Thymus of Rats

Cited by 14 publications

References 6 publications

Stress and the Immune System: Immunological Aspects of Depressive Illness

Stress and the Immune System: Immunological Aspects of Depressive Illness

Sympathetic innervation of murine thymus and spleen: A comparative histofluorescence study

Effects on the Immune System of Lesioning and Stimulation of the Nervous System: Neuroimmunomodulation

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