Histochemical Demonstration of the Alterations in the Renal Dehydrogenases Activities Induced by Lead in Wistar Albino Rats (Rattus norvegicus).

Jarrar, Bashir M.; Mahmoud, Zuhair N.

doi:10.1248/jhs.48.106

Cited by 8 publications

(3 citation statements)

References 28 publications

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“…This might be due to increased cellular activity and nuclear interruption in the mechanism of lead detoxification. Some of the pleomorphism alterations seen in the present study were in agreement with (Abd El-aal, 1989); (Nehru and Kaushal, 1993); (Jarrar et al, 2006) and (Jarrar and Taib, 2012). Zusman et al, (1991) in their studies indicate that nuclear polymorphism is seen in hepatic dysplasia and carcinomatous lesion.…”

Section: Discussionsupporting

confidence: 91%

Anatomical and Histological Study of the Effect of Lead on Hepatocytes of Albino Rats

Metwally¹,

Negm²,

El-din³

et al. 2015

IJBMR

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Lead is found at low levels in Earth's crust, mainly as lead sulfide. Lead is toxic for virtually all organs of the body and has significant debilitating effects on the nervous, renal, hepatic and hematopoietic systems. The liver is considered as one of the target organs affected by lead toxicity owing to its site of storage after exposure. Also, the liver is being one of the major organs involved in the biotransformation and detoxification of toxic substances. Absorbed lead is stored in soft tissues mainly in the liver via the portal vein, so that it is the first organ for which the histological analysis can be used to examine the morphological changes that reflect possible lead effects on somatic cells. The present study aimed to determine the structural damage in the liver by histological study and biochemical assay of liver enzyme levels. 45 rats were divided into 3 groups. Group I (control group) included 15 rats that were given distilled water by orogastric tube. Group II (experimental group) included 15 rats that were given lead acetate in a dose of 4mg/kg body weight by orogastric tube for two weeks. Group III (experimental group) included 15 rats given lead acetate by the same route and dose for four weeks. Significant increase of liver enzymes SGPT and SGOT was observed in experimental groups (group II and III). Administration of lead acetate for 2 weeks (group II) induced alteration in the hepatic architecture as evident by some of the hepatocytes appeared with acidophilic slightly vacuolated granular cytoplasm while others showed markedly vacuolated hypereosinophilic cytoplasm, Mononuclear cellular infiltration was seen in the portal tract. While in Group III, diffuse affection of the hepatic lobule was evident by extensive vacuolation of the hepatocyte cytoplasm, dark and eccentric nuclei. Others showed kayolytic nucleus, congested central vein, narrow or even obliterated blood sinusoids. The portal area revealed proliferation of bile ducts and congestion of its vessels. The hepatic architecture was disorganized with marked affection of the hepatocytes. In conclusion it was found that lead acetate is toxic to liver and this toxicity is paralleled with increased duration of exposure.

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Section: Discussionsupporting

confidence: 91%

Anatomical and Histological Study of the Effect of Lead on Hepatocytes of Albino Rats

Metwally¹,

Negm²,

El-din³

et al. 2015

IJBMR

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“…Reduction of MDH activity with lead exposure has been documented [4]. Although other common toxic metals such as mercury, cadmium or aluminum may also be sources of toxicity onboard the Space Station, there are no indications in the literature that these other toxic agents affect MDH activity as does lead.…”

Section: Dear Editormentioning

confidence: 99%

Cosmonauts and lead: Resorption and increased blood lead levels during long term space flight

Kondrashov

2006

J. Med. Toxicol.

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“…Additionally, the crystallographic structure of perovskite materials incorporates anionic oxides or halogens. Commonly, perovskite composites contain a hybrid of organic-inorganic lead (Pb) or tin (Sn) halide, posing potential risks to human health and the ecosystem (Jarrar and Mahmoud, 1999, 1999b, 2002, 2000a; Jarrar, 2001; Taib et al, 2006). Nevertheless, various challenges, including manufacturability, stability, durability, and potential risks to human health and the environment, must be addressed before perovskite can emerge as a competitive commercial technology.…”

Section: Introductionmentioning

confidence: 99%

Toxicity assessment of perovskite nanocomposites: In vivo study

Makableh,

Jarrar,

Al-Shdaifat

2023

Toxicol Ind Health

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Perovskite solar cells display potential as a renewable energy source because of their high-power conversion efficiency. However, there is limited understanding regarding the potential impact of perovskite on human health and the ecosystem. In this study, two sets of male Wistar albino rats received 35 injections of perovskite composite at a dosage of 0.372 mg/kg body weight. The animals underwent thorough examinations, encompassing morphometric, hematological, biochemical, histological, and behavioral analyses. Liver, kidney, and testis biopsies were processed and examined histologically. Additionally, two groups of mice (perovskite-treated and control mice, each with n = 10) underwent three behavioral tests: the Elevated Zero Maze test, Marble Burying test, and Light-Dark Box test. Perovskite-treated rats displayed a significant increase in levels of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, triglycerides, cholesterol, creatinine, blood urea nitrogen, white blood cells, and platelets. However, total bilirubin levels decreased, with no significant alteration in albumin values. Furthermore, exposure to perovskite composite resulted in a slight decrease in lactate dehydrogenase and red blood cell count. Histopathological examination revealed hepatic hydropic degeneration, Kupffer cells hypertrophy and hyperplasia, and renal hydropic degeneration, while testicular tissues remained unaffected. Moreover, behavioral changes were observed in perovskite-treated mice, including depression, anxiety, and compulsive burying activity. These findings suggest that exposure to perovskite can lead to significant hematological and biochemical changes, as well as hepatorenal histopathological alterations and behavioral changes. Additionally, chronic exposure to perovskite materials may induce structural and functional alterations in vital organs.

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Histochemical Demonstration of the Alterations in the Renal Dehydrogenases Activities Induced by Lead in Wistar Albino Rats (Rattus norvegicus).

Cited by 8 publications

References 28 publications

Anatomical and Histological Study of the Effect of Lead on Hepatocytes of Albino Rats

Anatomical and Histological Study of the Effect of Lead on Hepatocytes of Albino Rats

Cosmonauts and lead: Resorption and increased blood lead levels during long term space flight

Toxicity assessment of perovskite nanocomposites: In vivo study

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