Histochemical studies of obstructive adenitis in human submandibular salivary glands. I. Immunohistochemical demonstration of lactoferrin, lysozyme and carcinoembryonic antigen

Abstract

Immunohistochemical detection of lactoforrin (LF), lysozyme (LZ) and carcinoembryonie antigen (CEA) was made in obstructive adenitis of the submandibular glands. Atrophic and altered acinar cells in the early stage of the lesion stained strongly for I.F, whereas they were unreactive or stained slightly for LZ. Ductal cells usually stained for LZ Staining for CEA was strong and irregularly distributed in altered acinar cells. Duct‐like structures and dilated ductal segments in the chronic stage were generally negative for LF LZ and CEA. Secretory components in luminal cavities gave abundant staining for LF. LZ and CEA. Histocytes which infiltrated into the connective tissue in the later stage showed a positive LZ reaction.

Immunohistochemical expression of monoclonal antibody against epithelial membrane antigen in salivary gland tumors.

“…In obstructive lesions of submandibular glands, EMA distribution is able to serve as a functional marker of both acinar and ductal cells (23). While Gusterson et al (7) failed to detect EMA in the serous acinar cells, and such a staining pattern is quite similar to that of carcinoembryonic antigen (CEA) in serous acinar cells (1,2,26,27). These differences suggest the determinant recognized by monoclonal antibody to human EMA used may have a widely characteristic cross reactivity due to certain glycoprotein or a part of sugar residues.…”

Antimicrobial Peptides in Saliva and Salivary Glands: Their Roles in the Oral Defense System

“…This indicates the secretory mechanism of LF by acinar cells (185,186). LF is expressed in both normal salivary gland cells and tumors cells (187)(188)(189)(190)(191)(192)(193). In these studies, the coexpression of LF with LY has been demonstrated in salivary gland tumors.…”

Immunohistochemical localization of human epidermal growth factor/.GAMMA.-urogastrone in submandibular glands and in their obstructive lesions.

“…Pathological findings of obstructive salivary gland lesions have already been described (24). In the initial or early stage atrophied acinar cells and irregularly shaped ductal segments are found as signs of an inflammatory reaction.…”