Histochemical studies on intestinal metaplasia adjacent to gastric cardia adenocarcinoma in subjects at high-incidence area in Henan, north China

Gao, Shegan; Wang, Lidong; Fan, Zong-Min; Li, Jilin; He, Xin; Guo, Ruifeng; Xie, D Y; He, Xinwei; Gao, Shanshan; Guo, Hao; Wang, Jun-Kuan; Feng, Xiaoshan; Ma, Buyun

doi:10.3748/wjg.v11.i30.4634

Cited by 5 publications

(3 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our results confirmed a significant difference in the proportion of IM subtypes among various EGC locations, as reported previously also in Chinese patients 29 . We showed that EGC with IM demonstrated distinct clinicopathological features, such as a significantly higher proportion of cases with non‐poorly cohesive‐carcinoma, en bloc resection, and eCura C‐1 grade.…”

Section: Discussionsupporting

confidence: 91%

Clinicopathological significance of intestinal metaplasia in endoscopically resected early gastric carcinoma

Cheng,

Zhang,

Zhuang

et al. 2023

J of Digest Diseases

View full text Add to dashboard Cite

ObjectiveTo investigate the clinicopathological and prognostic significance of intestinal metaplasia (IM) in endoscopically resected early gastric carcinoma (EGC).MethodsThe study included 136 consecutive EGC cases, resected by endoscopic submucosal dissection over a 5‐year period, divided into early gastric cardiac (EGCC, n=60) and non‐cardiac (EGNCC, n=76) groups. Goblet cell IM and subtypes were determined with histologic and immunostaining methods. Recurrence‐free survival was compared among various IM subtype groups.ResultsIM was identified in 128 (94.1%) EGC cases with following subtypes: complete (n=39), incomplete (n=27), mixed (n=62), and absent (n=8). The incomplete subtype was significantly more common in EGCC and exhibited a lower frequency of en bloc resection than the complete subtype. The frequency of synchronous or metachronous gastric tumor was significantly more common in EGCC with complete IM than with incomplete IM. Overall, compared to EGC without IM, EGC with IM showed a significantly higher frequency of non‐poorly cohesive carcinoma, en bloc resection, and non‐ eCuraC‐1 grade. EGNCC with IM was significantly associated with negative resection margins and en bloc resection. The 5‐year recurrence‐free survival was significantly lower in EGNCC patients with incomplete IM, compared to those with mixed IM. The independent risk factors for recurrence‐free survival included tumor size > 2 cm and eCura grades.ConclusionsSubtyping IM in EGC helped predicting endoscopic resectability, prognosis, and risk of synchronous or metachronous gastric tumor. The significance of IM differed between EGCC and EGNCC. Future studies with lager samples and longer follow‐up periods are warrant to validate our findings.This article is protected by copyright. All rights reserved.

show abstract

Section: Discussionsupporting

confidence: 91%

Clinicopathological significance of intestinal metaplasia in endoscopically resected early gastric carcinoma

Cheng,

Zhang,

Zhuang

et al. 2023

J of Digest Diseases

View full text Add to dashboard Cite

show abstract

“…These two chronic damages contributes to the high incidence of IM and inflammation at the cardiac mucosa (Odze, 2005;McColl, 2006). Our previous research showed that the incidence of IM in tissue adjacent to gastric cardiac adenocarcinoma is much higher than gastric cardiac biopsy tissue from normal population (Gao et al, 2005). The result suggest that IM is an important precancerous lesion.…”

Section: Discussionmentioning

confidence: 89%

Expression of CDX2 and Villin in Gastric Cardiac Intestinal Metaplasia and the Relation with Gastric Cardiac Carcinogenesis

Xiao¹,

Ru²,

Sun³

et al. 2012

Asian Pacific Journal of Cancer Prevention

Self Cite

View full text Add to dashboard Cite

“…GCA is the most common malignant tumor of digestive tract in Henan Province, China (Gao et al 2005 ). Recent decades have seen an alarming increase in the incidence of GCA, while non-cardia gastric adenocarcinoma has decreased (Abdi et al 2019 ).…”

Section: Discussionmentioning

confidence: 99%

Survival influence of gender on 42,345 patients with gastric cardia adenocarcinoma

Zhao

Song

et al. 2022

J Cancer Res Clin Oncol

View full text Add to dashboard Cite

Purpose Some studies indicated that gender is associated with prognostic of cancer, However, currently the prognostic value of gender for gastric cardia adenocarcinoma (GCA) survival is unclear. The aim of our study is to reveal the influence of gender on the prognosis of patients with GCA. Patients and methods A total of 42,345 cases Chinese GCA patients were enrolled from our previously established GCA and esophageal cancer databases. The clinicopathological characteristics were retrieved from medical records in hospital. The follow-up was performed through letter, telephone or home interview. Among GCA patients, there were 32,544 (76.9%) male patients with the median age 62 years (range 17–97) and 9,801 (23.1%) female patients with the median age 61 years (range 17–95 years). The Chi-square test and Kaplan–Meier method were used to compare the continuous variables and survival. Cox proportional hazards model was used for competing risk analyses, hazard ratios (HRs) and 95% confidence intervals (CIs) were evaluated. Results Men had shorter GCA-specific survival than women by multivariate analysis (HR 1.114; 95% CI 1.061 to 1.169; P < 0.001). Whether premenopausal, perimenopausal or postmenopausal, the survival of women was better than that of men (premenopausal vs. male, P < 0.001; perimenopausal vs. male, P < 0.001; postmenopausal vs. male, P = 0.035). It was worth noting that in patients with stages I, II, III, and IV, female patients survive longer than male patients (P = 0.049; P = 0.011; P < 0.001; P = 0.044, respectively). Conclusion Gender is an independent prognostic factor for patients with GCA. In comparison with men, women have a significantly better outcome. Smoking and drinking may be protective factors for male GCA patients.

show abstract

Histochemical studies on intestinal metaplasia adjacent to gastric cardia adenocarcinoma in subjects at high-incidence area in Henan, north China

Cited by 5 publications

References 22 publications

Clinicopathological significance of intestinal metaplasia in endoscopically resected early gastric carcinoma

Clinicopathological significance of intestinal metaplasia in endoscopically resected early gastric carcinoma

Expression of CDX2 and Villin in Gastric Cardiac Intestinal Metaplasia and the Relation with Gastric Cardiac Carcinogenesis

Survival influence of gender on 42,345 patients with gastric cardia adenocarcinoma

Contact Info

Product

Resources

About