Histochemical Studies on the Pathogenesis of Idiopathic Non-Arteriosclerotic Cerebral Calcification

Light Microscopy and Ultrastructural Studies of Sturge-Weber Disease

“…The same finding has been described in other idiopathic nonaterosclerotic calcifications, e. g., the Fahr disease [1,5], The acid mucopolysaccharidic material is inside the vessel wall and while increasing in size, it moves to outside the vessels, although it remains frequently in close contact with them. It may be further suggested on the basis of our findings that the inor ganic component of the calcification, i. e.. calcium phosphate, precipitates on the granular formations of the organic matrix mainly outside the vessel wall.…”

Abnormal systemic metabolism of iron, porphyrin, and calcium in fahr's syndrome

“…saccharide, alkalic protein gel is formed. Calcium and phosphate are deposited as hydroxyapetite crystals in this perivascular ground substance, but there may be initial impregnation of these areas with iron before calcium deposition if the calcium and phosphorus metabolism is deranged [19,29,31,32). In addition to calcium, phosphate, and iron, the brain calculi may contain elevated levels of copper [31,33) and cystine Our patient's brain showed excess acid mucopolysaccharide material confined to areas of mineralization and calcification (see Fig 3).…”

Aluminum Accumulation in Human Brain Tissues

“…Also, excessive amount of Ca can often accumulate in the surrounding cerebral vessels or in the matrix outside neuronal cells. These phenomena occur in typical aged individuals or in the event of certain diseases [21] . The same mechanisms that trigger the accumulation of Fe and Ca may also be responsible for excess accumulations of Al, Ti and Cr in the brain tissues.…”