Histochemistry of Monoamine Oxidase in the Developing Rat Brain

Robinson, N.

doi:10.1111/j.1471-4159.1967.tb09519.x

Cited by 28 publications

(3 citation statements)

References 6 publications

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“…The evidence in this and earlier studies (Friede, 1962a;Rubinstein et al, 1962) does suggest that the active microglia and hypertrophic astrocytes in both neocortex and subjacent white matter have a substantial metabolic turnover soon after cerebral injury. Nerve fibres did not show the marked changes for most enzymes exhibited by other organelles; however, a raised 5'-nucleotidase activity was apparent and the varicose distribution of monoamine oxidase seen in normal fibres (Robinson, 1967) was depleted. Progress in the changes in activity with time of the enzymes catalysing the release of phosphate showed distinct variations.…”

Section: Discussionmentioning

confidence: 75%

Histochemical changes in neocortex and corpus callosum after intracranial injection.

Robinson¹

1969

Journal of Neurology, Neurosurgery & Psychiatry

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The penetration of a syringe needle or electrode into the brain, causing localized physical changes such as a high compression front with displacement of whole cells and other cells suffering from various degrees of temporary distortion, would be expected to produce disturbances in metabolism. Subsequent intracranial injection of small quantities of fluid may produce changes in pH, electrolyte concentration, ionic strength, temperature, and the disequilibrium of colloidal suspensions. Less clearly defined effects on metabolism due to inflammatory processes and trauma would also be likely to occur. This paper reports the effects of intracranial penetration of a microneedle and subsequent injection of 5 p,l. physiological saline on the metabolic activities of enzymes controlling important metabolic pathways in the brain. Two areas were investigated-namely, the cerebral cortex and the corpus callosum. Following injection, the animals were allowed to recover and observations on enzymes of glucose, thiamine and phosphate metabolism, amine oxidation, and acetylcholinesterase within nerve cells and glia during the period of 31 days post-operation were made by histochemical techniques. MATERIALS AND METHODSAdult male Lister rats weighing between 250 and 300 g were anaesthetized with ether, the hair shaved off the scalp, and the animal secured in a stereotaxic apparatus. Under aseptic conditions a sagittal incision was made, the skull exposed and scraped clean. The dura mater was exposed by drilling a burr-hole at Area 4 of the motor cortex (Krieg, 1946) and a sterilized specially drawn fine glass microneedle (less than 200 t in diameter) was introduced to the predetermined depth. Using a Hamilton 100p1. syringe, 5 pl. isotonic saline solution were injected over a period of 10 min by a motor-driven micrometer. The syringe needle was withdrawn, 300,000 u. Penidural given intraperitoneally, and the skin incision 'Present address:

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Section: Discussionmentioning

confidence: 75%

Histochemical changes in neocortex and corpus callosum after intracranial injection.

Robinson¹

1969

Journal of Neurology, Neurosurgery & Psychiatry

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“…Finally, the sharp decline in spontaneous activity that begins during the third week of life is correlated with the gradual development of telencephalic inhibitory structures. Many studies have shown that the morphological (Jacobson, 1963), electrophysiological (Deza & Eidelberg, 1967), neurochemical (Robinson, 1967), and functional properties of the telencephalon are the last to reach maturity, with the most rapid growth occurring between 15-30 days postnatally in the rat.…”

Section: Discussionmentioning

confidence: 99%

“…Numerous studies examining the morphological, electrophysiological, and biochemical maturation of the central nervous system support this general principle of development. Thus, the rate of myelin formation (Jacobson, 1963), increases in neurotransmitter levels and their metabolizing enzymes (Robinson, 1967(Robinson, ,1968, and many other indices of functional and morphological maturity appear first in the spinal cord, then in the brainstem, and finally in the diencephalon and telencephalon. In a like fashion, considerable evidence suggests that the later maturing centers act to modulate or control early developing structures.…”

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confidence: 99%

Ontogeny of starvation-induced behavioral arousal in the rat.

Moorcroft¹,

Lytle²,

Campbell³

1971

Journal of Comparative and Physiological Psychology

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Spontaneous locomotor activity of neonatal and weanling rats was measured in stabilimeter activity cages scaled to the size of the animals under a wide range of temperature and food-deprivation conditions. Activity was low for the first 10 days of life and then increased sharply, reaching a peak nearly 10 times that of normal adult animals 16-20 days postpartum. Activity then declined rapidly to near-adult levels by 28 days of age. This dramatic change in the activity levels of the developing rat is correlated with major ontogenetic changes in the structure and functioning of the central nervous system. These changes may reflect a caudal-rostral sequence of development, in which brainstem excitatory centers and their afferent inputs mature earlier than do the more phylogenetically advanced telencephalic inhibitory centers.In a classic series of papers, Hughlings-Jackson (collected in Taylor, 1931, 1932 proposed that the development of the central nervous system proceeds in a caudalcranial direction with later maturing higher systems acquiring control over early maturing more primitive systems. Numerous studies examining the morphological, electrophysiological, and biochemical maturation of the central nervous system support this general principle of development. Thus, the rate of myelin formation (Jacobson, 1963), increases in neurotransmitter levels and their metabolizing enzymes (Robinson, 1967(Robinson, ,1968, and many other indices of functional and morphological maturity appear first in the spinal cord, then in the brainstem, and finally in the diencephalon and telencephalon. In a like fashion, considerable evidence suggests that the later maturing centers act to modulate or control early developing structures. Simple motor reflexes that are present early in infancy, for example, disappear as telencephalic structures reach

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Monoamine Oxidase Inhibitors: Animal Pharmacology

Squires

1987

Handbook of Psychopharmacology

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Histochemistry of Monoamine Oxidase in the Developing Rat Brain

Cited by 28 publications

References 6 publications

Histochemical changes in neocortex and corpus callosum after intracranial injection.

Histochemical changes in neocortex and corpus callosum after intracranial injection.

Ontogeny of starvation-induced behavioral arousal in the rat.

Monoamine Oxidase Inhibitors: Animal Pharmacology

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