Histocompatibility Antigens and Habitual Abortion

Cauchi, Maurice N.; Tait, Brian D.; Wilshire, M.I.; Koh, S.H.; Mraz, Grant; Kloss, Michael; Pepperell, R. J.

doi:10.1111/j.1600-0897.1988.tb00229.x

Cited by 29 publications

(15 citation statements)

References 18 publications

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“…Concerning HLA class I antigens, Cauchi et al reported that HLA-B35 was significantly lower in patients with unexplained recurrent abortion compared with a control population [4], which is in good agreement with the results of this study.…”

Section: Discussionsupporting

confidence: 92%

“…In this context, there have been reports concerning the frequency and sharing of HLA antigens in couples who experienced recurrent spontaneous abortions. Recent investigations, however, demonstrated that the incidence of shared HLA antigens was not significantly higher in couples with unexplained recurrent abortions [4,5,21,27,33]. Recent investigations, however, demonstrated that the incidence of shared HLA antigens was not significantly higher in couples with unexplained recurrent abortions [4,5,21,27,33].…”

Section: Discussionmentioning

confidence: 96%

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HLA-class I antigens in patients with unexplained recurrent abortion

Imai¹,

Takakuwa²,

Ishii³

et al. 2001

Journal of Perinatal Medicine

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In order to clarify the genetic background of recurrent spontaneous abortion, the frequency of HLA-A, -B, and -C alleles was analyzed in eighty-nine patients with a history of unexplained primary recurrent abortion. The frequency of each HLA-A, -B, and -C antigen allele was calculated in patients with recurrent abortion and their husbands, and compared with the frequencies in the general population represented by 207 individuals in the Niigata district of Japan. The incidence of individuals homozygous for the HLA-A, -B, and -C alleles was also compared between the patient group and the control group. The frequency of HLA-B35 in the patient group (5 of 89, 5.6%) was significantly lower than in the general population (40 of 207, 19.3%) (Odds Ratio, 0.25; 95% Confidence Interval, 0.09-0.65; P < 0.005; Pc, not significant). The frequencies of other HLA-A, -B, and -C alleles were not significantly different between the patient group and the general population. No significant difference in the frequency of HLA-A, -B, and -C alleles was observed between the husband group and the general population. The incidence of individuals homozygous for HLA-A, -B, or -C alleles in the patient group was not significantly different from the general population. The significantly lower frequency of HLA-B35 in patients with unexplained recurrent abortion suggests that the Th2-associated immune reactions may be lacking in such patients, as it has been reported that an enhanced Th2 response in conjunction with a decreased T Th1 response is a common immune reaction in HLA-B35-positive individuals.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 96%

HLA-class I antigens in patients with unexplained recurrent abortion

Imai¹,

Takakuwa²,

Ishii³

et al. 2001

Journal of Perinatal Medicine

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“…absence of anti-paternallymphocytotoxic antibodies," increased paternal HLA sharing, 8,9 and increased homozygosity for HLA loci. ll, 12 There is conflicting data in relation to most ofthese parameters, however. Other studies have shown that there is no association of recurrent abortion with increased HLA sharingr' or lack of maternal serum blocking antibodies in MLR.…”

Section: Introductionmentioning

confidence: 99%

Predictors of Pregnancy Success in Repeated Miscarriage

Cauchi

Pepperell

Kloss

et al. 1991

American J Rep Immunol

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Factors that may have a bearing on subsequent pregnancy success or failure in patients with recurrent abortion were examined in 165 women with a history of three or more consecutive miscarriages in the first trimester. The overall success rate was 67.9%. Factors that were found to correlate significantly with success rate were length of abortion history, total number of abortions, interval from last miscarriage to present pregnancy, and whether there was any degree of subfertility. Logistic regression analysis showed that the abortion x years index and maternal age accounted for all the variation observed in our data. Where all other known causes of abortions are excluded, recurrent aborters can be subdivided into two populations--namely, those with a relatively good prognosis characterized by a short abortion history and absence of subfertility problems, compared to those with a poor prognosis namely those with a long abortion history or presence of subfertility problems. These data clearly demonstrate major differences in success rates in women depending on the number of abortions and the length of abortion history (abortion x year index), particularly in women over the age of 30 years.

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“…11-14,2o And there are some reports that the failure of maternal recognition was due to significant HLA sharin~between couples of unexplained recurrent abortions.l ': 5 Recent reports, however, have demonstrated that sharing ofHLA antigens was not significantly increased overall within couples with recurrent abortions compared with controls. [18][19][20] We previously reported that significant compatibility was not observed with the HLA-A,B,C antigens in couples with a history of unexplained recurrent abortions, whereas the significant compatibility was obtained with HLA-DR antigens.P" It is well recognized that there is strong linkage disequilibrium between the HLA-DR and HLA-DQ antigens because of very close…”

Section: Discussionmentioning

confidence: 99%

Significant Compatibility Does Not Exist at the HLA‐DQB Gene Locus in Couples With Unexplained Recurrent Abortions

Takakuwa

Higashino

Ueda

et al. 1992

American J Rep Immunol

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The polymerase chain reaction-restricted fragment length polymorphism (PCR-RFLP) method was used for both examining compatibility at the HLA-DQB1 gene locus and determining HLA-DQ antigen polymorphism in spouses of unexplained recurrent abortions. Genomic DNA samples were prepared from peripheral mononuclear cells from patient and control couples. Two hundred and thirty base pair fragments of the second exon of the HLA-DQB genes were selectively amplified. Amplified DNAs were digested with the restriction endonucleases, Fok I, Hae III, Hha I, Rsa I and Sau3A I, and subjected to electrophoresis in a polyacrylamide gel. The RFLPs showed that habitual aborters and their husbands had neither significantly frequent alleles nor shared common alleles at the HLA-DQB locus when compared to the control group. Since significant HLA-DQB compatibility was not observed between the spouses and unexplained recurrent aborters, in order to determine whether or not HLA compatibility is responsible for the genesis of unexplained recurrent abortions, it is imperative to further examine the compatibility between other HLA gene loci.

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Histocompatibility Antigens and Habitual Abortion

Cited by 29 publications

References 18 publications

HLA-class I antigens in patients with unexplained recurrent abortion

HLA-class I antigens in patients with unexplained recurrent abortion

Predictors of Pregnancy Success in Repeated Miscarriage

Significant Compatibility Does Not Exist at the HLA‐DQB Gene Locus in Couples With Unexplained Recurrent Abortions

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