Histocompatibility System in Renal Transplantation

Dmitrieva, N. G.; Яковчик, О. Н.; Ватазин, А В; Zulkarnaev, Aleksei; Федулкина, В. А.

doi:10.18786/2072-0505-2014-31-83-87

Cited by 2 publications

(3 citation statements)

References 4 publications

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“…Для ХГН, НС відносний ризик високий (RR > 2) при наявності HLA HLA-A23, А24, А28; B8, В38, В41, В44; DR1, DR4, DRw52, причинна роль (σ > 0, 1) МНС -це група генів, що знаходиться на короткому плечі 6-ї хромосоми в регіоні 4-Мb, яка складається з трьох класів -І, ІІ, ІІІ і продуктами яких є експресія на мембранах клітин антигенів головного комплексу гістосумісності -HLA (human leukocyte antigen), які приймають участь в регуляції імунної відповіді організму, в підтримці імунного гомеостазу і деяких метаболітичних функцій [2,3].…”

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“…Деякі дослідники називають антигени ГКГ -«імунним паспортом, групою білої крові», вони забезпечують функціональну взаємодію практично всіх імунокомпетентних клітин. Антигени системи HLA, набір яких забезпечує унікальність клітин індивідуума, дозволяє організму розпізнавати чужерідні антигени і усувати їх [2,4].…”

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“…Найбільш важливими в класі І МНС є локуси А, В та С, так звані «класичні», які кодують традиційні трансплантаційні антигени і є високополіморфними. Насьогодні виявлено 60 специфічностей в локусі А, 136 в локусі В і 38 -в локусі С [2,12]. Молекули класу ІІ МНС (HLA DP, DQ та DR) знайдено тільки на поверхнях антиген-презентуючих імунних клітин (В-лімфоцитів, макрофагів, дендритних клітин, клітин Лангерганса) [6,13].…”

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Peculiarities of phenotypes of patients with pyelo- and glomerulonephritis by HLA distribution analysis

Driianska

Petrina

Velychko

et al. 2018

Ukr. Journ. Nephrol. and Dial.

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Studies devoted to the role of human leucocyte antigens (HLA) in pathogenesis of chronic kidney disease (CKD) have demonstrated the associative links of the HLA antigens, which stipulate the relative and attributive risks of some autoimmune diseases, with immune disorder and a high production of pro-inflammatory cytokines. The aim of our study was to determine the peculiarities of phenotypes of CKD patients according to the distribution of HLA-A, B and DR antigens and to conduct their comparative analysis in patients with pyelonephritis (PN) and glomerulonephritis (GN). Methods: The distribution of HLA-A, B, DR antigens in 384 CKD patients (120 with PN and 264 with GN) was analyzed. HLA antigens were defined using a standard microlymphocytotoxic test on the Terasakiґs planchette with special panels of anti-HLA serums (20 antigens of locus A, 31 – B and 9 – DR). The control group consisted of 350 healthy donors. The HLA antigen frequencies in normal and diseased subjects were compared taking each antigen separately, using χ2 test. The etiologic fraction (attributive risk s > 0,1) was counted using the formula: s = x - y/I- y, where x is frequency of antigen in patients and y is frequency in healthy. The s reading was considered reliable when it exceeded 0.1. Results. The causal role (σ > 0,1) was determined for А10, А11; В14, В16 for PN; antigens-protectors - А2, В21, В35, В40. For CGN, NS the relative risk is high (RR > 2) at the presence of HLA-A23, А24, А28; B8, В38, В41, В44; DR1, DR4, DRw52 in phenotype, the causal role in etiopathology (σ>0.1) is indicated for A24,А28; B8; DR1, DR4, DRw52; the disease protectors are B12 and B16. Conclusion. Conclusion. The features of the HLA-phenotype of patients with pyelo- and glomerulonephritis were shown. It allowed to establish the interconnectedness of the antigens of the histocompatibility complex with the risk of kidney diseases developing, which could help to personificate of the treatment and predicte of the course of the disease.

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Peculiarities of phenotypes of patients with pyelo- and glomerulonephritis by HLA distribution analysis

Driianska

Petrina

Velychko

et al. 2018

Ukr. Journ. Nephrol. and Dial.

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Diagnostic value of anti-HLA antibody monitoring in the diagnosis of immunological complications following kidney transplantation

Aleksandrova,

Dmitriev,

Borovkova

et al. 2024

RJTAO

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Introduction. Despite improvements in immunosuppressive therapy procedures, immunological complications continue to be a major cause of kidney graft loss. The level of pre-existing and de novo synthesized anti-HLA antibodies (AB) has shown high significance in modern diagnosis of graft rejection and assessment of the efficacy of anti-crisis therapy.Objective: to analyze the frequency and specificity of pre-existing and de novo synthesized (including donor-specific), anti-HLA antibodies, to assess their impact on acute rejection crisis and kidney transplant (KT) outcomes in the early postoperative period.Materials and methods. We retrospectively analyzed the treatment outcomes of 637 patients, who received a deceased-donor kidney transplant at Sklifosovsky Research Institute of Emergency Care from 2020 to 2022. Pre-existing and de novo synthesized anti-HLA AB, including donor-specific antibodies (DSA), were determined and their impact on the incidence of acute rejection crisis (ARC) in the early postoperative period and on kidney graft function was assessed.Results. In non-sensitized patients, the ARC rate was 10.7% (n = 58), primary initial graft function was noted in 354 patients (65.6%), and satisfactory function at discharge was observed in 377 patients (70%). Pre-existing anti-HLA AB was detected in 97 recipients (15.2%); ARC developed in 14 recipients (14.4%) from this group, 51 (52.6%) patients had primary initial function, and 62 (63.9%) exhibited satisfactory function at discharge. De novo anti-HLA AB synthesis after transplantation was noted in 70 (11%) patients, ARC in 10 of them (16.7%), 38 (54.3%) had primary function, and 43 (61.4%) had satisfactory function at discharge. DSA synthesis was detected in 10 patients, ARC was diagnosed in 5 (50%) of them, primary initial function and satisfactory function at discharge were noted in 3 (30%) recipients.Conclusions. The presence of pre-existing and/or de novo anti-HLA AB synthesis after KT under rationally selected immunosuppressive therapy did not statistically significantly affect the early outcomes of graft function. However, DSA synthesis statistically significantly increased the incidence of acute rejection, kidney graft dysfunction and increased the time of recovery of nitrogen excretory function.

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Histocompatibility System in Renal Transplantation

Cited by 2 publications

References 4 publications

Peculiarities of phenotypes of patients with pyelo- and glomerulonephritis by HLA distribution analysis

Peculiarities of phenotypes of patients with pyelo- and glomerulonephritis by HLA distribution analysis

Diagnostic value of anti-HLA antibody monitoring in the diagnosis of immunological complications following kidney transplantation

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