Histoenzymatic and morphometric changes occurring in nerve cells of gyrus cinguli following treatment of young rats with vincristine

Kozik, M; Szczech, J

doi:10.1016/s0232-1513(83)80012-7

Cited by 6 publications

(2 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…While in the treated experiments with VCR they dropped to 18314 units for females F1 and 21659.2 units for females F2, and 32331.2 units for males F2, statistical analysis indicated that the difference of F1 females, F2 females and F2 males with the control were significant. This result is in agreement with Kozik & Szczech [28] , who observed that administration of therapeutic doses of vincristine to young rats brings about a drop of the neuronal AChE activity. were 38515.7 units, in female F2 were 38651.5 units, and males F2 were 21014.5 units (Fig.…”

Section: Estimation Activity Of Che Enzymesupporting

confidence: 92%

The Genetic Effect of the Combined Action of Vincristine and Fennel Plant Extract on the Germ Cells of Drosophilla melanogaster

Al-Twany¹,

Ahmed²,

Kurdi³

2008

sci

View full text Add to dashboard Cite

This study was designed to investigate the mutagenic potentiality of the anticancer drug vincristine and fennel plant extract on Drosophilla melanogaster using two test systems, the sex linked recessive lethal (SLRL) and estimating the activity of cholinesterase enzyme (ChE) in F1 and F2 bar eye females and F2 wild types males. A wild type Strain Oregon-R (or-R) male flies of D. melanogaster were treated on a medium containing a concentration of one of individually of the two agents, followed by combined treatment in an alternative way of fennel extract followed by vincristin, then vincristin followed by fennel extract and finally the two agents together. The results showed no significant increase in the percentage of the S.L.R.L in all stages of spermatogenesis in all treatments. Meanwhile, vincristine and fennel plant extract showed a genotoxic effects in the three categories of the two generations of S.L.R.L, F1 females heterozygous F2 bar eye females and F2 wild type males on the genetic background of ChE in all treatments.

show abstract

Section: Estimation Activity Of Che Enzymesupporting

confidence: 92%

The Genetic Effect of the Combined Action of Vincristine and Fennel Plant Extract on the Germ Cells of Drosophilla melanogaster

Al-Twany¹,

Ahmed²,

Kurdi³

2008

sci

View full text Add to dashboard Cite

show abstract

“…6) (Figs. 9-11 (24,36) and, unlike other lipophilic Yi nca alkaloids (1), exert no overt central nervous system toxicity unless they are accidentally delivered to the brain (11,13,42 (19,20,32,33,37).…”

Section: Introductionmentioning

confidence: 99%

Peripheral Neuropathy Induced by Intravenous Administration of Vincristine Sulfate in the Rabbit.

et al. 1995

View full text Add to dashboard Cite

The lack of a suitable animal model for the peripheral neuropathy that often follows the systemic administration of the chemotherapeutic agent vincristine sulfate (VCR) has hampered the correlation between experimental and clinical patterns of this neuropathy. New Zealand rabbits have been recently found to develop, after iv injection of a VCR total dosage similar to that used in humans, a peripheral polyneuropathy characterized by electrophysiological changes that overlap those observed in the clinical setting. The present study was aimed at investigating the ultrastructural features of 3 different nerves (sural, peroneal, and medial gastrocnemius) in rabbits treated with 3 VCR doses that fall within the range (0.2-0.3 mg/kg iv) known to be efficacious chemotherapeutically and active neurotoxicologically. Regardless of the dose and the nerve under examination, histopathologic alterations appeared in the form of an overall loss of myelinated fibers, accompanied by successful attempts of regeneration and remyelination. Fibers undergoing Wallerian degeneration were characterized by an axoplasm, which was either watery-flocculent or divided in 2 or more regions as a consequence of ingrowing Schwann cell processes from the adaxonal surface. These ingrowths tended to isolate axoplasmic areas, retaining a fairly normal structure from other areas already crowded with altered organelles and cytoskeletal elements. In any event, neurofibrillary accumulations were rarely seen. These patterns are discussed with reference to those reported in the ultrastructural studies of human cases and confirm the suitability of rabbit as an animal model for VCR-induced peripheral neuropathy.

show abstract

The protective role of parsley extract against vincristine mutagenicity in Drosophila melanogaster

Alakilli

2010

Saudi Journal of Biological Sciences

View full text Add to dashboard Cite

In this study, Drosophila melanogaster males were treated with parsley plant extract and the anticancer drug vincristine (VCR) singly and in combined treatments (pre, co and post-treatments) to detect the mutagenic effects by using sex-linked recessive lethal test (SLRL) and estimation of cholinesterase enzyme (ChE) activities in order to compare the sensitivity of the two test systems. A wild type strain Oregon-R (Or-R) male flies of D. melanogaster were reared on a medium containing one concentration of each of VCR and parsley (4 ml/100 ml medium) in each single and combined treatment. Also the activity of ChE was estimated in some insects of the two generations: F1 females, F2 bar eye females (heterozygous) and F2 wild types males. The results indicate that both of parsley and vincristine did not cause significant increases of SLRL test in either the single or combined treatments. In contrast, estimation of ChE activities showed significant increase in all the broods within single and combination treatments, except female of the second generation of spermatid brood which treated with parsley and VCR at the same time. It is concluded that enzyme estimation is more sensitive than SLRL test for detection the mutagenic effect for parsley's extract and vincristine.

show abstract

Histoenzymatic and morphometric changes occurring in nerve cells of gyrus cinguli following treatment of young rats with vincristine

Cited by 6 publications

References 12 publications

The Genetic Effect of the Combined Action of Vincristine and Fennel Plant Extract on the Germ Cells of Drosophilla melanogaster

The Genetic Effect of the Combined Action of Vincristine and Fennel Plant Extract on the Germ Cells of Drosophilla melanogaster

Peripheral Neuropathy Induced by Intravenous Administration of Vincristine Sulfate in the Rabbit.

The protective role of parsley extract against vincristine mutagenicity in Drosophila melanogaster

Contact Info

Product

Resources

About