Histoenzymological and ultrastructural study of a bifocal calcifying epithelial odontogenic tumor. characteristics of epithelial cells and histogenesis of amyloid-like material

Chomette, G; Auriol, M; Guilbert, F

doi:10.1007/bf00689339

Cited by 31 publications

(14 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Morimoto et al [1983] demonstrated ALP immunostain and enzyme activity associated with CEOT epithelial cell membranes. Additionally, high activities of ALP and ATPases were previously demonstrated by light and electron microscopy on the cytoplasmic membrane of a CEOT tumor, similar to findings in the stratum intermedium cells of the normal tooth germ from which these tumor cells are thought to arise [Chomette et al, 1984]. Our preliminary results suggest that ALP may be associated with the CEOT mineralization potential.…”

Section: Discussionsupporting

confidence: 62%

“…Several reports have emphasized that CEOTs have obvious mineralization features such as nodular deposition of congophilic amyloidlike material with partial mineralization [Kang et al, 2006]. This pseudo-amyloid substance is thought to represent abnormal EMPs associated with mineralization [Chomette et al, 1984]. Our study found higher expression levels of ALP in CEOT-1 compared to AB-1 and KCOT-1.…”

Section: Discussionsupporting

confidence: 62%

See 1 more Smart Citation

Differential Enamel and Osteogenic Gene Expression Profiles in Odontogenic Tumors

Ren

Diniz

Piazza

et al. 2011

Cells Tissues Organs

View full text Add to dashboard Cite

Odontogenic tumors occur within the jaw bones and may be derived from odontogenic epithelium or ectomesenchyme or contain active components of both tissue types. We investigated the gene expression profile of enamel matrix proteins (EMPs), genes related to osteogenesis, and the mineralization process in odontogenic tumor cell populations focusing on an ameloblastoma (AB-1), a keratocystic odontogenic tumor (KCOT-1), and a calcifying epithelial odontogenic tumor (CEOT-1). All cell populations were shown to be epithelial in origin by CK14 expression. All tested EMPs were expressed by all odontogenic tumor cell types, with higher transcript levels seen in the AB-1 population especially for AMEL, AMBN, and ODAM. CEOT-1 cell populations showed a greater content of ALP-positive cells as well as higher ALP mRNA levels. Using qRT-PCR, we found a higher expression of 8 genes in the CEOT-1 compared to the AB-1 and KCOT-1. In this study we demonstrated the establishment of AB-1, KCOT-1 and CEOT-1 cell populations. The unique gene expression profiles of AB-1, KCOT-1, and CEOT-1 cells and their interactions with the surrounding microenvironment may support their unique tumor development, progression, and survival.

show abstract

Section: Discussionsupporting

confidence: 62%

Section: Discussionsupporting

confidence: 62%

Differential Enamel and Osteogenic Gene Expression Profiles in Odontogenic Tumors

Ren

Diniz

Piazza

et al. 2011

Cells Tissues Organs

View full text Add to dashboard Cite

show abstract

“…Most investigators are of the opinion that it arises from stratum intermedium as tumor cells are morphologically similar and possess a high alkaline phosphatase and adenosine triphosphate activity. 5 Other possible considerations for the cell of origin are from oral epithelium, dental lamina or its remnants, and reduced enamel epithelium. 2 The CEOT shows three important histological features.…”

Section: Discussionmentioning

confidence: 99%

“…Small, intrabony mandibular lesions with well-defined borders are treated by simple enucleation or curettage followed by judicious removal of a thin layer of bone adjacent to the tumor. 5 Large tumors require aggressive approach by segmental resection, hemimandibulectomy and hemimaxillectomy, which cause bone discontinuity requiring reconstruction procedures, such as grafting or distraction osteogenesis. 7 Recurrence rate of 10 to 20% following conservative treatment is reported.…”

Section: Treatmentmentioning

confidence: 99%

Cystic Variant of Calcifying Epithelial Odontogenic Tumor

Narayanswamy¹,

Rao²,

Dutt³

et al. 2017

IJOCRWEB

View full text Add to dashboard Cite

Organization in 1992 classified it as a benign odontogenic tumor, which is exclusively epithelial in its tissue of origin. The differential diagnosis for CEOT should include adenomatoid odontogenic tumor (AOT), calcifying odontogenic cyst, ameloblastic fibro-odontoma, and odontoma.3 Few CEOT cases have been associated with impacted teeth resembling dentigerous cyst radiographically; true cystic variants are less reported. We report a case of a cystic variant of a CEOT in a young male patient. CASE REPORTA 26-year-old male patient visited our center with history of pain and swelling in the right posterior region of the mandible since 1 year. The patient started noticing an asymptomatic swelling about a year back, which was of the size of a walnut, and which eventually grew to the present-day size and was associated with pain for a week. The swelling, about 3 × 3 cm in the right body of mandibular region, extended from 1st premolar region to the 2nd molar region and was just behind the corner of the mouth until just below the lower border of mandible. The skin over the swelling appeared normal, intraorally extending from 1st premolar to the 2nd molar and causing obliteration of the sulcus, with the mucosa over it appearing inflamed. The consistency of the swelling was hard and tender on palpation. Right submandibular lymph node is palpable and tender. Tooth 46 was missing. Radiographically, a well-circumscribed radiolucent lesion in the right body of mandible associated with an impacted molar in the lower border was seen. Aspiration of the lesion revealed pus. Surgical excision of the same considering it to be an infected dentigerous cyst was planned. Under local anesthesia, a vestibular incision was placed, and complete enucleation of the lesion and the removal of the tooth were carried out. The provisional clinical diagnosis of ossifying fibroma, CEOT, ameloblastoma, and odontogenic myxoma was made. The specimen was sent for histopathological evaluation. Histopathology findings revealed a neoplasm composed of cells arranged as sheets and anastomosing small and large islands. These cells were interspersed by prominent homogeneous hyaline acellular material. Areas of concentric lamellated calcifications were seen. The neoplastic cells have well-defined cell borders, abundant eosinophilic cytoplasm, and hyperchromatic mildly pleomorphic nuclei. A few bizarre nuclei were seen; however, no abnormal mitosis was seen. Normal mature lamellar bony trabeculae were seen between tumor islands interspersed with large areas of hemorrhages, as

show abstract

“…[3–5] This idea is based on the morphological similarity of the tumor cells to the normal cells of stratum intermedium and a high activity of alkaline phosphatase and adenosine triphosphate. [6] It has been suggested that amyloid deposition within Pindborg tumor is an immunologic response to these stratum intermedium cells. Others insist that it arises from remnants of the primitive dental lamina found in the initial stage of odontogenesis, and these epithelial rests are the more likely true progenitor cell.…”

Section: Discussionmentioning

confidence: 99%

Calcifying epithelial odontogenic tumor (Pindborg tumor)

Singh

Sahai²,

Singh

et al. 2011

Natl J Maxillofac Surg

View full text Add to dashboard Cite

The calcifying epithelial odontogenic tumor (CEOT) is a rare entity and represents less than 1% of all odontogenic tumors. Dr. J J Pindborg (1958) first described four cases of this unusual lesion; subsequently Shafer et al coined the term Pindborg tumor. This lesion is a locally aggressive benign odontogenic neoplasm arising from epithelial tissue. It occurs most commonly in 4th-5th-6th decade of life and bears no gender predilection. A case of CEOT in a 50-year-old male arising in the left body region is described.

show abstract

Histoenzymological and ultrastructural study of a bifocal calcifying epithelial odontogenic tumor. characteristics of epithelial cells and histogenesis of amyloid-like material

Cited by 31 publications

References 30 publications

Differential Enamel and Osteogenic Gene Expression Profiles in Odontogenic Tumors

Differential Enamel and Osteogenic Gene Expression Profiles in Odontogenic Tumors

Cystic Variant of Calcifying Epithelial Odontogenic Tumor

Calcifying epithelial odontogenic tumor (Pindborg tumor)

Contact Info

Product

Resources

About