Histogenesis of diffuse small cleaved cell lymphoma. An immunohistochemical and molecular genetic (bcl-2 gene) study with comparison to follicular small cleaved cell lymphoma and mantle zone lymphoma

Abe, Masafumi; Ono, Nobutaka; Tominaga, Kunihiko; Hara, Hiroshi; Seto, Masao; Fukuhara, Shirou; Wakasa, Haruki

doi:10.1002/1097-0142(19920815)70:4<821::aid-cncr2820700417>3.0.co;2-y

Cited by 11 publications

(1 citation statement)

References 40 publications

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“…The presence of CD5 on the lymphoma cells served to distinguish this from a typical FL, but we were unable to definitively differentiate this CD10+ MCL from a CD5+ FL by flow cytometry. The latter has been reported in the literature, 31,32 and we have encountered such cases as well, although not in the present case series. Cyclin D1 immunohistochemical analysis was required to establish a diagnosis of MCL in this case.…”

Section: Discussionsupporting

confidence: 66%

Assessment of CD10 in the Diagnosis of Small B-Cell Lymphomas

McKenna

Kroft

2002

Am J Clin Pathol

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We evaluated the usefulness of multiparameter flow cytometry with cluster analysis in the diagnosis of a series of 100 well-characterized small B-cell lymphomas (SBCLs). The histologic diagnoses in the 100 cases were follicular lymphoma (FL) in 58, marginal zone lymphoma (MZL) in 17, small lymphocytic lymphoma in 15, and mantle cell lymphoma (MCL) in 10. Of the 58 FLs, 57 were CD10 positive (98% sensitivity). The 1 negative case was unusual in that it occurred in the small intestine. However; architectural, cytologic, and immunohistochemicalfeatures were diagnostic of FL. Of 42 other SBCLs, 2 were CD10+ (95% specificity); 1 was a CD5+/cyclin D1 + MCL, and the other was an extranodal MZL. We found that assessment of CD10 expression using multiparameter flow cytometry with cluster analysis is highly sensitive and specific for the diagnosis of FL, validating its usefulness in situations in which adequate tissue is not available for definitive histologic diagnosis.

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Section: Discussionsupporting

confidence: 66%

Assessment of CD10 in the Diagnosis of Small B-Cell Lymphomas

McKenna

Kroft

2002

Am J Clin Pathol

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Primary central nervous system lymphomas. Immunophenotypic, virologic, and cytogenetic findings of three patients without immune defects

Itoyama

Sadamori

Tsutsumi

et al. 1994

Cancer

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Background. Primary central nervous system (PCNS) lymphoma is a relatively rare disease, but an increasing incidence is reported. The Epstein‐Barr virus (EBV), which is often found in lymphomas of immuno‐compromised patients, has been implicated in the development of lymphomas. Many cytogenetic analyses of nodal B cell lymphomas have been performed, but few studies on PCNS lymphomas have been reported. Methods. The detection of EBV genome using the polymerase chain reaction (PCR) method and cytogenetic studies were performed, in addition to histopathologic and immunophenotypic approaches in biopsied tissue from three patients with PCNS lymphoma. Immunosuppressive states and exposure to mutagens were not clear in all patients. Results. Histopathologic examination disclosed a diffuse type of malignant lymphoma in all patients. Immunophenotypic studies revealed B cell phenotype in all patients, two of whom showed positive reaction for CD5. The PCR method revealed no involvement of EBV genome in tumors in any patients. The cytogenetic study showed clonal chromosome abnormalities in all patients, and abnormalities of chromosome 1 (1q21), 6 (‐6, 6q15 and 6q21), 7 (‐7 and 7p15), and 14 (14q24 and 14q32) were prominent. The t(6;14)(q15;q32) observed in Patient 1 is the first case to be reported in human de novo lymphoma. Conclusions. These findings indicate that the causative role of EBV in PCNS lymphoma without immune defects is not clear. The cytogenetic findings were similar to those observed in nodal B‐cell lymphoma, suggesting that the origin of PCNS lymphoma cells does not differ from nodal B cell lymphoma cells cytogenetically.

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Multiple lymphomatous polyposis of the gastrointestinal tract. An extensive histopathologic and immunohistochemical study of 12 cases

Lavergne

Brouland

Launay

et al. 1994

Cancer

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Background. Multiple lymphomatous polyposis (LP) is a rare entity, characterized by multiple polypoid tumors involving several segments of the gastrointestinal tract. Methods. In this large retrospective series of 12 patients with LP, histologic and immunohistochemical features were investigated from patients with multiple biopsy samples from each site (500 gastrointestinal biopsies). Immunohistochemistry was performed on paraffin embedded biopsies from 12 patients and on frozen tissue biopsies from 8 patients, for each of whom at least two different anatomic sites were studied. Results. Histologic features always were characterized by nodules located in mucosa and submucosa composed of lymphomatous, small cleaved cells. B‐cell phe‐notype of the neoplastic cells was the same phenotype as adult mantle‐zone cells or fetal follicle cells (frequent coexpression of surface IgM and surface IgD, and weak expression of CD5, CD35+, CDw32+, and CD23‐). Tested cases expressed bcl‐2. Five to 20% of LP cells were positive for the monoclonal antibody Ki‐67. Five patients died within 5‐32 months after diagnosis. Frequent extradigestive sites were also identified. There were two unique findings: five cases with digestive tract lymphoepithelial lesions (LEL), and one secondary transformation to large B‐cell malignant lymphoma. Conclusions. To the authors' knowledge, this is the largest series so far of LP studied with immunohistochemistry on frozen sections. Mantle‐cell B cell phenotype of the nodular monotonous, small cleaved cells is confirmed. This entity may be classified as mantle‐cell lymphoma with a similar agressive clinical course, and treated as a high grade B‐cell lymphoma. The authors know of no such LEL that has been reported previously, and secondary transformation has been described only briefly in one case.

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Histogenesis of diffuse small cleaved cell lymphoma. An immunohistochemical and molecular genetic (bcl-2 gene) study with comparison to follicular small cleaved cell lymphoma and mantle zone lymphoma

Cited by 11 publications

References 40 publications

Assessment of CD10 in the Diagnosis of Small B-Cell Lymphomas

Assessment of CD10 in the Diagnosis of Small B-Cell Lymphomas

Primary central nervous system lymphomas. Immunophenotypic, virologic, and cytogenetic findings of three patients without immune defects

Multiple lymphomatous polyposis of the gastrointestinal tract. An extensive histopathologic and immunohistochemical study of 12 cases

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