Histoid leprosy in a young man

Large hypochromic annular plaques on the trunk

“…Treatment for leprosy can be challenging, especially when nerve damage has occurred. The World Health Organization guidelines recommend a two-drug regimen of rifampicin and dapsone with a duration of treatment of six months for paucibacillary patients and twelve months with clofazimine added to the therapeutic regimen for multibacillary patients [2,4,8]. In summary, because of the polymorphic character and the severity of the disease and potential disfiguring complications, it is important for clinicians to recognize leprosy at an early stage of the disease in order to prevent irreversible neurological damage [4].…”

“…Leprosy, also known as Hansen's disease, is a contagious and chronic infectious granulomatous disease caused by Mycobacterium leprae that mainly affects the skin, mucous membranes, and peripheral nervous system [1,2]. Depending on the immunological profile of each individual, the spectrum of the disease presents polar clinical forms, from tuberculoid (paucibacillary) with few skin lesions to lepromatous (multibacillary) with more than five skin lesions, along with the borderline forms with hybrid characteristics [2,3]. The cutaneous manifestations of leprosy are polymorphic, ranging from macular lesions with sensorial deficiency and elevated dyschromic areas to diffuse, infiltrated plaques and erythematous nodules that ultimately become necrotic and ulcerated [3][4][5].…”

“…Leprosy, also known as Hansen's disease, is a contagious and chronic infectious granulomatous disease caused by Mycobacterium leprae that mainly affects the skin, mucous membranes, and peripheral nervous system [1,2]. Depending on the immunological profile of each individual, the spectrum of the disease presents polar clinical forms, from tuberculoid (paucibacillary) with few skin lesions to lepromatous (multibacillary) with more than five skin lesions, along with the borderline forms with hybrid characteristics [2,3].…”

Große hypochrome ringförmige Plaques am Rumpf

“…Z. B. eine Verwechslung mit anderen dermatologischen Erkrankungen wie Sarkoidose, Psoriasis, Lupus vulgaris, Syphilis und Lymphomen, die Lepra-Symptome imitieren können [2,5,6].…”

“…Lepra auch Hansen-Krankheit genannt, ist eine ansteckende und chronische granulomatöse Infektionskrankheit, die durch Mycobacterium leprae verursacht wird und hauptsächlich die Haut, Schleimhäute und das periphere Nervensystem befällt [1, 2]. Je nach dem jeweiligen immunologischen Profil des Patienten, weist das Spektrum der Krankheit polare klinische Formen von tuberkuloiden (paucibazillären) mit wenigen Hautläsionen bis hin zu lepromatösen (multibazillären) mit mehr als fünf Hautläsionen sowie Grenzformen mit hybriden Merkmalen auf [2,3]. Die kutanen Manifestationen der Lepra sind polymorph und reichen von makulären Läsionen mit sensorischen Defiziten und erhöhten dyschromen Arealen bis hin zu diffusen, infiltrierten Plaques und erythematösen, letztlich nekrotischen und ulzerierenden Knötchen [3][4][5].…”