Histoire de la kétamine : une molécule ancienne qui a toujours la cote

Daré, Brendan Le; Pelletier, Romain; Morel, Isabelle; Gicquel, Thomas

doi:10.1016/j.pharma.2021.04.005

Cited by 11 publications

(3 citation statements)

References 45 publications

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“…Ketamine was once considered to be ideal for general anesthesia, however, it was quickly revealed to possess a relatively high risk of psychological adverse effects.When recovering from ketamine anesthesia, patients often report unusual symptoms, such as hallucinations, delusions, confusion, and sometimes "out-of-body" and "near-death" experiences, which has led to the discontinuation of ketamine from mainstream anesthetic usage in humans. Still, ketamine and its commercial combinations, due to their unique properties (including profound analgesia, stimulation of the sympathetic nervous system, bronchodilation, and minimal respiratory depression), are an important alternative to other intravenous anesthetics and are therefore in extensive use in specialized clinics, especially in pediatrics, psychiatry, and dentistry [32][33][34].…”

Section: Anesthesiamentioning

confidence: 99%

Ketamine, an Old–New Drug: Uses and Abuses

Savić Vujović,

Jotić,

Medić

et al. 2023

Preprint

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Ketamine as an old - new drug has variety of clinical implications. In the last 30 years, ketamine has become popular for acute use in humans. Ketamine at standard doses is principally utilized for the induction and maintenance in surgical procedures. Beside its use in anesthesia and analgesia, recently studies had shown that ketamine find the place in the treatment of asthma, epilepsy, depression, bipolar affective disorders, alcohol and heroin addiction. Its mechanism of action is complex, but it mostly acts as a noncompetitive antagonist at the N-methyl-D-aspartate (NMDA) receptor. Ketamine is generally considered relatively secure and does not result in serious adverse effects when used at low doses and for short periods- Also, ketamine is known as a powerful psychostimulant. During the past decade, ketamine has been one of the commonly abused drug.

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Section: Anesthesiamentioning

confidence: 99%

Ketamine, an Old–New Drug: Uses and Abuses

Savić Vujović,

Jotić,

Medić

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…However, owing to its distinctive properties including potent analgesia, stimulation of the sympathetic nervous system, bronchodilation, and minimal respiratory depression, ketamine and its commercial combinations continue to serve as a significant alternative to other intravenous anesthetics. Consequently, they are extensively utilized in specialized clinics, particularly in pediatrics, psychiatry, and dentistry [ 61 , 62 , 63 ].…”

Section: Anesthesiamentioning

confidence: 99%

Ketamine, an Old–New Drug: Uses and Abuses

Savić Vujović,

Jotić,

Medić

et al. 2023

Pharmaceuticals

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Ketamine as an old–new drug has a variety of clinical implications. In the last 30 years, ketamine has become popular for acute use in humans. Ketamine in standard doses is principally utilized for the induction and maintenance of surgical procedures. Besides its use in anesthesia and analgesia, recent studies have shown that ketamine has found a place in the treatment of asthma, epilepsy, depression, bipolar affective disorders, alcohol and heroin addiction. Ketamine primarily functions as a noncompetitive antagonist targeting the N-methyl-D-aspartate (NMDA) receptor, but its mechanism of action is complex. It is generally regarded as safe, with low doses and short-term use typically not leading to significant adverse effects. Also, ketamine is known as a powerful psychostimulant. During the past decade, ketamine has been one of the commonly abused drugs.

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“…The primary mechanism of ketamine involves inhibiting NMDA receptor function, disrupting the excitatory transmission of glutamate, potentially leading to emotional and perceptual changes including hallucinations, dissociation, and mood fluctuations. [7] Ketamine might induce an increase in heart rate and elevated blood pressure, posing risks for patients with cardiovascular diseases. Its usage can trigger mood swings, anxiety, and altered mental states, especially at higher doses.…”

Section: Introductionmentioning

confidence: 99%

Role of Flt3l and Rps15 in ketamine anesthesia

Zhang,

2024

Medicine

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Ketamine is the only intravenous narcotic that has sedative, analgesic, and anesthetic effects. However, the role of Flt3l and ribosomal protein S15 (Rps15) in ketamine anesthesia remains unclear. GSE26364 and GSE93041 were downloaded from gene expression omnibus. Multiple datasets were merged and batched. Differentially expressed genes (DEGs) were screened and weighted gene co-expression network analysis was performed. Construction and analysis of protein–protein interaction network. Gene ontology (GO) and Kyoto Encyclopedia of Gene and Genome were performed. A heat map of gene expression was drawn. TargetScan was used to screen miRNAs regulating DEGs. 882 DEGs were identified. According to the GO analysis, these DEGs were mainly enriched in cell differentiation, extracellular region, and cytoplasm. The Kyoto Encyclopedia of Gene and Genome analysis revealed enrichment in pathways such as the PPAR signaling pathway, TNF signaling pathway, Hippo signaling pathway, and IL-17 signaling pathway. In the Metascape enrichment analysis, GO enrichment categories included leukocyte differentiation, negative regulation of CREB transcription factor activity, and positive regulation of cell cycle. The protein–protein interaction network showed 10 core genes (Rpl7, Rpl18, Rps15, Rpl7l1, Flt3l, Rps16, Eprs, Rps19, Rps28, Rplp2).Gene expression heatmap showed that core genes (Rplp2, Flt3l, Rps15) were highly expressed in samples treated with ketamine anesthesia. Flt3l and Rps15 are highly expressed during ketamine anesthesia, and may be molecular targets.

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Histoire de la kétamine : une molécule ancienne qui a toujours la cote

Cited by 11 publications

References 45 publications

Ketamine, an Old–New Drug: Uses and Abuses

Ketamine, an Old–New Drug: Uses and Abuses

Ketamine, an Old–New Drug: Uses and Abuses

Role of Flt3l and Rps15 in ketamine anesthesia

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