Histologic and genetic assessment of explanted allograft valves

Neves, José Pedro; Monteiro, Carolino; Santos, R R; Martins, Ana Paula; Ramos, Sância; Ramos, Teresa Lopes; Calta, Carol; Rueff, José; Melo, João

doi:10.1016/0003-4975(95)00274-o

Cited by 22 publications

(13 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, there have been some reports about the immunogenicity of cryopreserved allografts. Some studies comparing homografts and the valves of transplanted hearts showed that leaflet cellularity of transplanted hearts is superior to that of homografts (5,6,7). These differences were consistent with the occurrence of an immune response in the homografts which was prevented or abrogated by immunosuppressive therapy administered to the transplanted hearts.…”

Section: Discussionmentioning

confidence: 83%

Histological and Immunohistological Study of Cryopreserved Aortic Valve Grafts: The Possibility of a Clinical Application for Cryopreserved Aortic Valve Xenograft

Yokose

Fukunaga²,

Tayama³

et al. 2002

Artificial Organs

View full text Add to dashboard Cite

The influence of preservation techniques on xenogeneic immune responses was examined to investigate the possibility of their clinical use. Mongrel dogs and pigs were used as allogeneic and discordant xenogeneic donors of aortic valve grafts, respectively. The allografts and xenografts were implanted in the abdominal aorta of mongrel dogs after cryopreservation or after fresh preservation. Allografts and xenografts were explanted at Days 7 and 42 for histological and immunohistochemical examination. In the fresh preserved allografts and the fresh preserved xenografts, the media of aortic wall grafts were significantly acellular at 7 days. Significant aortic medial destruction and neointimal proliferation with significant destruction of the valve leaflets was observed at 42 days. However, no differences were found among the preservation techniques in the xenogeneic grafts. To alleviate the lack of homografts, approaches such as the tissue-engineered graft may become an alternative in patients who are acceptable candidates.

show abstract

Section: Discussionmentioning

confidence: 83%

Histological and Immunohistological Study of Cryopreserved Aortic Valve Grafts: The Possibility of a Clinical Application for Cryopreserved Aortic Valve Xenograft

Yokose

Fukunaga²,

Tayama³

et al. 2002

Artificial Organs

View full text Add to dashboard Cite

show abstract

“…The procurement centers are invited to deliver the following arteries: thoracic descending aortã aortic bifurcation with a minimum of 1 cm aortic stump and external iliac arteries up to the groiñ both superficial femoral arteries with a minimal length of 15 …”

Section: Methodsmentioning

confidence: 99%

Banking and Distribution of Large Cryopreserved Arterial Homografts in Brussels: Assessment of 4 Years of Activity by the European Homograft Bank (EHB) with Reference to Implantation Results in Reconstruction of Infected Infrarenal Arterial Prostheses and Mycotic Aneurysms

Goffin¹,

Grandmougin²,

Woźniak³

et al. 1998

Vascular Surgery

View full text Add to dashboard Cite

arteries have been registered from 136 donors: 122 brain death cases and 14 cadavers (mean age 34 years, male/female ratio 1.52/1); 263 arteries were cryopreserved (113 aortas, 64 aortic bifurcations, and 86 femoral); 19 were discarded for atherosclerosis (6.7%); 10 batches of arteries were partially or totally discarded because of persistent contamination and further eight batches for positive or doubtful viral serology. One hundred patients were treated in nine European centers with one (N = 69) or more EHB homografts. Indications were: infected prosthesis 70 (17 with aortoenteric fistula); mycotic aneurysm 19 (four ascending aortas, two with bronchial fistula); neoplastic infiltration of subrenal aorta one; extracardiac reconstructions/shunts 10.(continued on next page) at NORTH DAKOTA STATE UNIV LIB on May 28, 2015 ves.sagepub.com Downloaded from 20 (Abstract continued)Results from homograft reconstructions in infected prosthesis or mycotic aneurysm were available in 90 patients. There were 19 early deaths and 24 early complications, three were directly graft-related and included a fatal case of homograft rupture. Sixtyseven vascular cases were followed up from 1 month onward (mean: 16 months): 50 were uneventful; there were nine late deaths, of which two resulted from graft-related digestive hemorrhage; there were eight cases of late complications; three arteries were partly explanted as a result of focal thrombosis. Four patients were lost to follow-up. In the cases of aortoenteric fistula, however, the results were disappointing with only five late survivors of the 16 treated patients. Finally, these results show that cryopreserved arteries seem to perform as well in the midterm as the fresh ones.Both the banking activity of cryopreserved homografts and the short-to mid-term performances of the implants in cases of prosthetic or native arterial infection are very satisfactory, provided no aortoenteric fistula is present. Cryopreserved arteries can also be used for extracardiac shunts and reconstructions. '

show abstract

“…Aortic homografts have similar properties as fresh human aortas have less immunological reaction, which may cause acute and late rejection . In this patient, the homograft showed excellent long‐term outcome in a post‐heart transplant patient on immunosuppression.…”

Section: Discussionmentioning

confidence: 73%

Replacement of Infected Aortic Prosthetic Graft with Aortic Homograft after Heart Transplantation: 13-Year Follow-Up

2013

View full text Add to dashboard Cite

Acute ascending aortic dissection (AAAD) is a rare complication after orthotopic heart transplantation. We report a patient with AAAD after heart transplantation in whom repair was complicated by infection of the ascending aortic prosthetic graft. This was successfully managed by re-do replacement with two cryopreserved aortic homografts. Despite extensive calcification in the wall, the homografts show no aneurysm or dilation after 10 years.

show abstract

Histologic and genetic assessment of explanted allograft valves

Cited by 22 publications

References 9 publications

Histological and Immunohistological Study of Cryopreserved Aortic Valve Grafts: The Possibility of a Clinical Application for Cryopreserved Aortic Valve Xenograft

Histological and Immunohistological Study of Cryopreserved Aortic Valve Grafts: The Possibility of a Clinical Application for Cryopreserved Aortic Valve Xenograft

Banking and Distribution of Large Cryopreserved Arterial Homografts in Brussels: Assessment of 4 Years of Activity by the European Homograft Bank (EHB) with Reference to Implantation Results in Reconstruction of Infected Infrarenal Arterial Prostheses and Mycotic Aneurysms

Replacement of Infected Aortic Prosthetic Graft with Aortic Homograft after Heart Transplantation: 13-Year Follow-Up

Contact Info

Product

Resources

About