Histologic and Genomic Analysis of Conjunctival SCC in African and American Cohorts Reveal UV Light and HPV Signatures and High Tumor Mutation Burden
Frederico O. Gleber-Netto,
Priyadharsini Nagarajan,
Oded Sagiv
et al.
Abstract:Purpose
Conjunctival squamous cell carcinoma (conjSCC) is more prevalent and aggressive in sub-Saharan African countries compared with the rest of the world. This study aims to compare the genomic, immunophenotypic, and histologic features between patients from the United States and Ethiopia, to identify etiopathogenic mechanisms and unveil potential treatment strategies.
Methods
We compared histologic features and mutational profiles using whole exome sequencing, high-… Show more
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