Histologic and Immunohistochemical Comparison of Intraductal Tubular Carcinoma, Intraductal Papillary-Mucinous Carcinoma, and Ductal Adenocarcinoma of the Pancreas

Tajiri, Takuma; Tate, Genshu; Kunimura, Toshiaki; Inoue, Kazuaki; Mitsuya, Toshiyuki; Yoshiba, M; Morohosh, Toshio

doi:10.1097/00006676-200408000-00006

Cited by 72 publications

(47 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…8,14,15,17,30,32,33 The neoplasm is composed of closely packed tubular glands and occasionally contains markedly complex cribriform glands and solid areas. 12,32,33 The tumor cells show eosinophilic cytoplasm and atypical nuclei. Immunohistochemical examination has revealed that ITC cells are focally positive for MUC1, but negative for MUC2 and MUC5AC.…”

Section: Discussionmentioning

confidence: 99%

Intraductal Tubulopapillary Neoplasms of the Pancreas Distinct From Pancreatic Intraepithelial Neoplasia and Intraductal Papillary Mucinous Neoplasms

Yamaguchi¹,

Shimizu²,

Ban³

et al. 2009

American Journal of Surgical Pathology

193

236

View full text Add to dashboard Cite

We have encountered cases of unusual intraductal pancreatic neoplasms with predominant tubulopapillary growth. We collected data on 10 similar cases of "intraductal tubulopapillary neoplasms (ITPNs)" and analyzed their clinicopathologic and molecular features. Tumor specimens were obtained from 5 men and 5 women with a mean age of 58 years. ITPNs were solid and nodular tumors obstructing dilated pancreatic ducts and did not contain any visible mucin. The tumor cells formed tubulopapillae and contained little cytoplasmic mucin. The tumors exhibited uniform high-grade atypia. Necrotic foci were frequently observed, and invasion was observed in some cases. The ITPNs were immunohistochemically positive for cytokeratin 7 and/or cytokeratin 19 and negative for trypsin, MUC2, MUC5AC, and fascin. Molecular studies revealed abnormal expressions of TP53 and SMAD4 in 1 case, but aberrant expression of beta-catenin was not observed. No mutations in KRAS and BRAF were observed in the 8 cases that were examined. Eight patients are alive without recurrence, 1 patient died of liver metastases, and 1 patient is alive but had a recurrence and underwent additional pancreatectomy. The mitotic count and Ki-67 labeling index were significantly associated with invasion. All the features of ITPN were distinct from those of other known intraductal pancreatic neoplasms, including pancreatic intraepithelial neoplasia, intraductal papillary mucinous neoplasm, and the intraductal variant of acinar cell carcinoma. Intraductal tubular carcinomas showed several features that were similar to those of ITPN, except for the tubulopapillary growth pattern. In conclusion, ITPNs can be considered to represent a new disease entity encompassing intraductal tubular carcinoma as a morphologic variant.

show abstract

Section: Discussionmentioning

confidence: 99%

Intraductal Tubulopapillary Neoplasms of the Pancreas Distinct From Pancreatic Intraepithelial Neoplasia and Intraductal Papillary Mucinous Neoplasms

Yamaguchi¹,

Shimizu²,

Ban³

et al. 2009

American Journal of Surgical Pathology

193

236

View full text Add to dashboard Cite

show abstract

“…[84][85][86][87] High expression levels of MUC1 and MUC4 have been detected in pancreatic cancer tissues and tumor cell lines, whereas their expression was undetectable in normal pancreas samples. 9,84,85,[88][89][90][91][92] An increase of the cellular levels of these mucins also seems to correlate with the progression of pancreatic cancer. 84,89,91 In this matter, it has been observed that MUC1 expression in human pancreatic cancer S2-013 cells was accompanied in vitro by increasing the invasiveness and motility of cells.…”

Section: Mucin Signalingmentioning

confidence: 99%

Recent Advances on the Molecular Mechanisms Involved in Pancreatic Cancer Progression and Therapies

Mimeault¹,

Brand²,

Sasson³

et al. 2005

Pancreas

102

View full text Add to dashboard Cite

This review describes the recent advances in the molecular events involved in pancreatic cancer initiation, progression, and metastasis. Additionally, the importance of deregulated cellular signaling elements as potential targets for developing novel therapeutic strategies against incurable forms of pancreatic cancer is reported. The emphasis is on the critical functions gained by numerous growth factors and their receptors, such as epidermal growth factor receptor, hedgehog signaling, and proangiogenic agents such as vascular endothelial factor and interleukin-8 for the sustained growth, survival, and metastasis of pancreatic cancer cells. The molecular mechanisms associated with antitumoral properties and the clinical benefits of gemcitabine alone or in combination with other cytotoxic agents for the treatment of pancreatic cancer are discussed.

show abstract

“…However, many tumor nodules show no residual non-neoplastic ductal epithelium at the periphery (135). The nodules are composed of either back to back tubular glands or punctuated sheets of tumor cells ( Figure 7B) (54,134,138). Despite the entity's name, the predominant growth pattern is tubular in ITPNs with papilla formation seen only focally in rare cases (135,139).…”

Section: Pathologic Featuresmentioning

confidence: 99%

“…However, because (7,134) many of the individual tumor nodules lack a peripheral rim of nonneoplastic ductal epithelium, it is often very difficult to determine whether invasive carcinoma is present (24,138). Foci in which there are thin strands of cells extending away from the edges of the nodules are regarded to represent stromal invasion (Figure 8).…”

mentioning

confidence: 99%

Intraductal neoplasms of the pancreas: an update

Aşkan

Bağcı²,

Memiş³

et al. 2017

TJPATH

View full text Add to dashboard Cite

ABStRACtwith improvements in imaging to detect silent pancreatic lesions and increases in the number of centers now performing pancreatic surgery, more surgeries have been performed for indications other than invasive carcinoma. This has enormously added to our knowledge of the intraductal neoplasms of the pancreas. In addition, our understanding of the genetics of these lesions has expanded with the introduction of routine molecular genetic analyses. In this review, we provide an update into the most common intraductal neoplasms, namely intraductal papillary mucinous neoplasm and intraductal tubulopapillary neoplasm. we first focus on their clinicopathologic and molecular features of relevance to the practicing pathologist and then discuss their differential diagnoses.

show abstract

Histologic and Immunohistochemical Comparison of Intraductal Tubular Carcinoma, Intraductal Papillary-Mucinous Carcinoma, and Ductal Adenocarcinoma of the Pancreas

Cited by 72 publications

References 17 publications

Intraductal Tubulopapillary Neoplasms of the Pancreas Distinct From Pancreatic Intraepithelial Neoplasia and Intraductal Papillary Mucinous Neoplasms

Intraductal Tubulopapillary Neoplasms of the Pancreas Distinct From Pancreatic Intraepithelial Neoplasia and Intraductal Papillary Mucinous Neoplasms

Recent Advances on the Molecular Mechanisms Involved in Pancreatic Cancer Progression and Therapies

Intraductal neoplasms of the pancreas: an update

Contact Info

Product

Resources

About