Histologic and receptor analysis of primary and secondary vestibulodynia and controls: a prospective study

Goetsch, Martha F.; Morgan, Terry K.; Korcheva, Veselina; Li, Hong; Peters, Dawn; Leclair, Catherine M.

doi:10.1016/j.ajog.2010.01.028

Cited by 83 publications

(116 citation statements)

References 21 publications

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“…5,22,23,27 A number of scientists have posited that vulvodynia may be the result of an altered immunoinflammatory response. 2,3,[28][29][30][31] If psychosocial risk factors associated with vulvodynia (e.g., childhood abuse) lead to a compromised immune system, this mechanistic pathway would be consistent with the broader, growing literature on the role of chronic stress in generating inflammation. 32,33 Childhood fear of abuse could be conceptualized as a chronic stressor.…”

Section: Discussionsupporting

confidence: 60%

Is Chronic Stress During Childhood Associated with Adult-Onset Vulvodynia?

Khandker

Brady

Stewart

et al. 2014

Journal of Women's Health

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Section: Discussionsupporting

confidence: 60%

Is Chronic Stress During Childhood Associated with Adult-Onset Vulvodynia?

Khandker

Brady

Stewart

et al. 2014

Journal of Women's Health

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“…Second, various studies have examined the role of vulvar nerve fiber density in vulvodynia. However, the results are contradictory in terms of the presence or absence of intraepithelial and dermal nerve fibers [40][41][42][43][44]. Additionally, using quantitative sensory testing methodologies, vulvodynia patients report lower pain thresholds than pain-free women, as well as increased pain intensity at supra-threshold levels [45].…”

Section: Biomedical Factorsmentioning

confidence: 99%

Female Sexual Pain Disorders: a Review of the Literature on Etiology and Treatment

Bergeron

Corsini‐Munt

Aerts

et al. 2015

Curr Sex Health Rep

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Female sexual pain disorders, although highly prevalent and increasingly studied, remain a distressing complaint for women and their partners. Empirical evidence points to a multifactorial conceptualization of the etiology, course, and associated difficulties of sexual pain; thus, treatment options span the medical, pelvic floor rehabilitation psychological and multimodal. Given the interpersonal context in which sexual pain occurs, recent work has underscored the importance of considering the dyadic framework in research and treatment. This review presents understanding from across disciplines focusing on the impact of sexual pain on the woman and the couple, proposed etiologic pathways and risk factors related to its development and course, and current treatment options. Recommendations for research point to an urgency for multidisciplinary exchanges in the development of conceptual models and refinement of targeted interventions.

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“…Anxiety levels and psychosexual differences in primaries associated with dys-menorrhea and lower systolic blood pressure, in contrast with local vulvar pathology for secondaries has been reported by Granot [11], but more research in this field is needed. On the other side, vulvar tissue status, neural hyperplasia, pain receptors, mast cells have also been reviewed in regard of significant histologic features [12,13].…”

Section: Discussionmentioning

confidence: 99%

Sexual Behaviors in Women with Primary and Secondary Provoked Vestibulodynia: A Controlled Study

Lambert¹,

Desrosiers²,

Chagnon³

et al. 2013

ASM

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Introduction: Provoked vestibulodynia affects 12% of the general female population and more specifically, 21% of women aged less than 30 years. Primary and secondary vestibulodynia are hypothesized to represent the endpoints of different etiologic pathways, although there is still little research addressing potential distinctions between these two groups, particularly with regard to sexuality. Aims: To compare sexual activity and behavior of women with provoked primary vestibulodynia (PVD1) and secondary vestibulodynia (PVD2) against age-matched controls. Methods: Fiftyseven participants (N = 57), mean age 25.72 (18 -41) recruited from a gynecology clinic underwent a gynaecological examination and completed a self-report questionnaire: 20 (N = 20) were diagnosed with primary provoked vestibulodynia (PVD1), 19 (N = 19) with secondary provoked vestibulodynia (PVD2), and 18 (N = 18) were medically confirmed as no-pain controls. Main outcome: To verify any differences in the sexual behavior between primary, secondary vestibulodynias and controls. Results: Mean pain duration differed significantly in participants with PVD1 at 73.8 months against those with PVD2 at 37.4 months (p = 0.003). Frequency of sexual activity also differed significantly between the three groups (p = 0.012): the controls were at 27.8% against 0% in primary and secondary vestibulodynias for once or more a day. No significant difference was observed for the sexual arousal time and masturbation frequency. Vaginal penetration was overrepresented in controls (p < 0.001) contrary to fellatio frequency (p = 0.016). Pain digital test was significantly different between the three groups in one finger (3.85 vs 0.08), two fingers (4.39 vs 0.06) or three fingers (5.39 vs 0.56) (PVD1 against controls), lubricated inserted fingers for pain verification (p < 0.001). Conclusions: Provoked vestibulodynia generates problems in the sexual response and coital activity, this syndrome reflecting absence of pre-existing sexual problems, notably in the masturbatory activity and oral receptive female sex.

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Histologic and receptor analysis of primary and secondary vestibulodynia and controls: a prospective study

Cited by 83 publications

References 21 publications

Is Chronic Stress During Childhood Associated with Adult-Onset Vulvodynia?

Is Chronic Stress During Childhood Associated with Adult-Onset Vulvodynia?

Female Sexual Pain Disorders: a Review of the Literature on Etiology and Treatment

Sexual Behaviors in Women with Primary and Secondary Provoked Vestibulodynia: A Controlled Study

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