Histologic characterization of regenerated tissues after pulp revascularization of immature dog teeth with apical periodontitis using tri-antibiotic paste and platelet-rich plasma

Endodontic repair in immature dogs' teeth with apical periodontitis: blood clot vs plasma rich in growth factors scaffold

“…Likewise, Simon and Smith (31) reported that scaffolds did not show better outcomes despite their use of growth factors, and they claimed that scaffolds were not essential for successful treatment. The current study demonstrated successful outcomes of treatment of immature permanent teeth with necrotic infected pulps using PRGF scaffold, which is in line with several previous studies (20,32,33) using PRP. PRGF is rich in growth factors and capable of enhancing cellular proliferation, differentiation and angiogenesis (21).…”

“…However, in another study, no significant difference was reported between the treatment outcomes of PRP and conventional blood clot scaffold after an 18-months follow-up (12). The current study demonstrated successful outcomes of treatment of immature permanent teeth with necrotic infected pulps using PRGF scaffold, which is in line with several previous studies (20,32,33) using PRP. The current study demonstrated successful outcomes of treatment of immature permanent teeth with necrotic infected pulps using PRGF scaffold, which is in line with several previous studies (20,32,33) using PRP.…”

Apical Revascularization after Delayed Tooth Replantation: An Unusual Case

“…The nature of tissues formed in the canal after revascularization therapy was first described by Thibodeau et al [21] after performing a study in immature dog teeth. It was observed that cementum-, bone-, and periodontal ligament-like tissues were formed, which was subsequently confirmed by other in vivo studies [22–24]. According to Simon and Smith [25], the origin of the formed tissue may not be so important from a clinical perspective, since the objective is to induce apical closure and healing of the periapical tissues and to keep the patient free from signs and symptoms, like in this current case report.…”

Clinical and radiographic evaluation of Biodentine and Mineral Trioxide Aggregate in revascularization of non‐vital immature permanent anterior teeth (randomized clinical study)

“…Sodium hypochlorite was then flushed from root canal with 20 mL saline to reduce any prolonged toxicity that could diminish the regeneration responses, decrease the risk of possible precipitates, and eliminate residual debris and remains of irrigant …”

“…25 Sodium hypochlorite was then flushed from root canal with 20 mL saline to reduce any prolonged toxicity that could diminish the regeneration responses, decrease the risk of possible precipitates, and eliminate residual debris and remains of irrigant. 26 The root canal was medicated with the antibiotic mix as its effectiveness was proven in eliminating bacteria from the infected dentine of root canals. Also, it was shown to be a valuable adjunct for revascularization procedures since it creates an environment favourable for the ingrowth of vasculature and regenerative cells.…”