Histologic Classification and Grading of Malignancy in Carcinoma of the Larynx

Jakobsson, P-J; Eneroth, C.-M.; Killander, D.; Moberger, G.; Mårtensson, Björn

doi:10.3109/02841867309131085

Cited by 440 publications

(256 citation statements)

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“…Then, we compared Periostin expression with invasion pattern and metastasis in 74 OSCC cases. Jacobsson's classification (patterns I -IV) was used for evaluation of invasion patterns, as shown in Figure 2A (Jacobsson et al, 1973). In 74 OSCC cases, there were 6, 8, 37 and 23 cases of patterns I, II, III and IV, respectively.…”

Section: Resultsmentioning

confidence: 99%

“…The sections were stained with haematoxylin and eosin for histological examination. All 74 tumours were graded according to the classification described by Jacobsson et al (1973) as patterns I, II, III and IV. For immunohistochemical examination of Periostin, a modification of the streptavidin -biotin -peroxidase-complex (SABC) method was used.…”

Section: Histopathological and Immunohistochemical Analysesmentioning

confidence: 99%

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Periostin is frequently overexpressed and enhances invasion and angiogenesis in oral cancer

et al. 2006

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Oral squamous-cell carcinoma (OSCC) is one of the most common types of human cancer. Typically OSCC cells show persistent invasion that frequently leads to local recurrence and distant lymphatic metastasis. We previously identified Periostin as the gene demonstrating the highest fold change expression in the invasive clone by comparing the transcriptional profile of parent OSCC cell line and a highly invasive clone. Here, we demonstrated that Periostin overexpression enhanced invasiveness in oral cancer cell lines. To know the role of Periostin in invasion, angiogenesis and metastasis in OSCC cases, we first examined the expression of Periostin mRNA in 31 OSCC cases by RT -PCR and Periostin protein in 74 OSCC cases by immunohistochemistry. Then, we compared the Periostin expression with invasion pattern, metastasis and blood vessel density. Periostin mRNA and protein overexpression were frequently found in OSCC cases and Periostin expression was well correlated with the invasion pattern and metastasis. Moreover, blood vessel density of Periostin-positive cases was higher than those of Periostin-negative cases. Interestingly, recombinant Periostin enhanced capillary formation in vitro in a concentration-dependant manner. In summary, these findings suggest that Periostin may promote invasion and angiogenesis in OSCC, and that Periostin can be a strong marker for prediction of metastasis in oral cancer patients.

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Section: Resultsmentioning

confidence: 99%

Section: Histopathological and Immunohistochemical Analysesmentioning

confidence: 99%

Periostin is frequently overexpressed and enhances invasion and angiogenesis in oral cancer

et al. 2006

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“…These include tumor size, tumor differentiation, mode of invasion, mitotic activity, microvascular invasion, and histologic grade of malignancy. 2,7,10,18,26,27 Tumor depth of invasion and vascular invasion were recently reported to be risk factors for cervical lymph node metastasis in patients with SCC of the head and neck. 26 Interestingly, patients with lymph node metastasis tended to report increased levels of spontaneous pain, suggesting that the process of tissue infiltration leading to metastasis may be responsible for increased spontaneous pain.…”

Section: Discussionmentioning

confidence: 99%

“…The histological mode of invasion was classified according to the YK classification system, 16,18 (Table 1) The chief compliant at first visit was "pain" in 32 patients, "swelling" in 44, "bleeding" in 4, "trismus" in 2, "loss of sensation" in 3, "delay of wound healing after extraction" in 1, and "nothing" or " request for further examination" in 23 cases.…”

Section: Clinicopathological Datamentioning

confidence: 99%

Pain may predict poor prognosis in patients with oral squamous cell carcinoma

Sato

Yamazaki

Satoh

et al. 2011

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, an

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Objectives:We have previously reported that the histological mode of invasion of oral squamous cell carcinoma (OSCC) is a significant risk factor for pain. We sought to determine whether pain is a risk factor for poor prognosis in patients with OSCC. Study Design:We evaluated the relationships between overall survival rates (OSRs) and clinicopathological variables, including gender, age, Tand N-stages, pathological findings and pain in 109 consecutive patients with untreated OSCC. Results:Of these 109 patients, 40 (37%) reported spontaneous pain.Univariate analysis showed that the OSR of patients with spontaneous pain was significantly lower than that of patients without pain (p=0.002).Multivariate analysis revealed that spontaneous pain and N-stage were significant independent predictors of OSR. Conclusion:This is the first report showing that spontaneous pain before treatment may be associated with poor prognosis in patients with OSCC.3

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“…Could these models be used to predict which low-stage patients are at risk for disease-progression? Tumor pattern of invasion at the tumor host interface is a consistent component of these models [11][12][13][14][15][16][17][18][19][20]. Other components have included lymphocytic host response, exophytic versus endophytic growth pattern, mitotic rate, degree of keratinization, and nuclear pleomorphism.…”

Section: Predictors Of Occult Metastases: Tumor Depth Of Invasionmentioning

confidence: 99%