Histologic classification of undescended testes

Nistal, Manuel; Paniagua, Ricardo; Díez-Pardo, Juan A.

doi:10.1016/s0046-8177(80)80078-5

Cited by 72 publications

(42 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Yine çeşitli kaynaklar, inmemiş testis kökenli erişkin tümörlerinin histolojik olarak genellikle germ hücreli tümör ya da seminom türünde olduğunu belirtmektedir (7,20,21) .…”

Section: Discussionunclassified

A study on the relationship between adult testicular tumors, and undescended testis

Büyükünal¹,

Büyükünal²

2017

Tcdd

View full text Add to dashboard Cite

“…Yine çeşitli kaynaklar, inmemiş testis kökenli erişkin tümörlerinin histolojik olarak genellikle germ hücreli tümör ya da seminom türünde olduğunu belirtmektedir (7,20,21) .…”

Section: Discussionunclassified

A study on the relationship between adult testicular tumors, and undescended testis

Büyükünal¹,

Büyükünal²

2017

Tcdd

View full text Add to dashboard Cite

“…In addition, testes were selected whose locations were either within the abdominal cavity proper or high up in the inguinal canal, frequent locations when removal of the cryptorchid testes are performed in adult men (1). We specifically excluded those cases of ectopic testes (or of cryptorchid testes found lower down in the inguinal canal) that may best be considered retractile testes whose pathological involvements most likely were either inconsequential or still poorly resolved (21)(22)(23)(24).…”

Section: Discussionmentioning

confidence: 99%

“…In this regard it is interesting to note the following. First, in approximately 30% of infantile patients the cryptorchid testes are found in the inguinal canal, and in these children it is possible to find spermatogonia in numbers not dissimilar from normal levels (1,24). Second, in biopsies obtained before and after puberty from the same patient suffering from androgen insensitivity syndrome, it is possible to observe spermatogonia in an appreciable number of tubules during infancy, but these are then conspicuously absent after puberty (32).…”

Section: Discussionmentioning

confidence: 99%

Androgen Receptor Expression in Sertoli Cells as a Function of Seminiferous Tubule Maturation in the Human Cryptorchid Testis1

Regadera

Martínez-García

González‐Peramato

et al. 2001

The Journal of Clinical Endocrinology &Amp; Metabolism

Self Cite

View full text Add to dashboard Cite

Androgen receptor (AR) immunohistochemistry was performed in an archival collection of adult human cryptorchid testes to determine whether AR cellular distribution and intensity of immunostaining were functions of the severity of cellular dysgenesis. The seminiferous tubule histology of cryptorchid testes collected from adults is marked by three specific patterns. 1) Seminiferous tubules are characterized as maintaining focal areas of germinal cell differentiation (albeit incomplete) that are interspersed with 2) tubules composed of Sertoli cells only, these latter cells being principally of the adult type, although dysgenetic and immature Sertoli cells may also be detected. 3) In contrast, there is a class of tubule that is characterized as being composed exclusively of Sertoli cells that are extremely dysgenetic in appearance. The majority of adult-type Sertoli cells found in the first types of tubules exhibited either robust or moderate AR staining intensity. Peritubular cells of these tubules also expressed a similar AR staining intensity. In contrast, in the more dysgenetic and immature type Sertoli cells found in the second type of tubules, the intensity of AR staining was significantly less, if not missing altogether. Finally, in the most dysgenetic tubules, Sertoli cell AR staining was never detected. To our knowledge, this is the first report in the literature that addresses the intensity of AR immunostaining in Sertoli cells of cryptorchid testes. The results presented herein are consistent with the interpretation that the intensity of AR staining in Sertoli cells diminishes as a function of the severity to which the cells are afflicted within a cryptorchid testis and that focal absence of AR expression in Sertoli cells correlates with a lack of local spermatogenesis in the tubules. (J Clin Endocrinol Metab 86: [413][414][415][416][417][418][419][420][421] 2001)

show abstract

“…Decrease in the mean tubular diameter and loss of germ cells in the STs are the traditional guidelines for the evaluation of cryptorchid testes [22], SCs have been found to be immature [23]. Fibro sis of the interstitium has been reported also in an infant [24], During late childhood, germ cells decrease [13,25], and their DNA content is abnormal [26].…”

Section: Mechanical Damagementioning

confidence: 99%

“…Fibro sis of the interstitium has been reported also in an infant [24], During late childhood, germ cells decrease [13,25], and their DNA content is abnormal [26]. Four groups can be recognized microscopically [23], ranging from only a slight thickening of the BM to STs with very narrow lumina or altogether obliterated, no germ cells and pseudopluristratified SCs.…”

Section: Mechanical Damagementioning

confidence: 99%