Histologic Comparison between Platelet-rich Plasma and Blood Clot in Regenerative Endodontic Treatment: An Animal Study

Pulp Revascularization of Immature Dog Teeth with Apical Periodontitis Using Triantibiotic Paste and Platelet-rich Plasma: A Radiographic Study

“…The dog has been selected as animal model because of its similarities in radicular structure to immature human teeth in their open apex characteristics (3,4,(17)(18)(19)(20) and its high growth rate that allows clinicians to obtain results in shorter experimental periods (21).…”

“…Khademi et al (20), in a study performed on mongrel dogs' teeth, found apical healing and apical closure in 70% of the cases and thickening of the walls in 40%, and Thibodeau et al (4), in a study performed on mixed breed canine model dogs, found thickened walls in 43.9% and apical closure in 54.9%. However, recently Zhang et al (19) have found 78% of radiographic apical closure and 78% of root walls thickening.…”

Histological assessment of regenerative endodontic treatment in animal studies with different scaffolds: A systematic review

“…Two studies showed pulp tissue in a few cases, 18,22 and one study reported formation of pulp-like tissue after regeneration without showing odontoblast cells. 16 One study reported formation of pulp-like tissue with odontoblast-like cells in the teeth treated with BC+ scaffolds. 15 …”

“…This connective tissue ingrowth from periapical tissue was densely infiltrated with young fibroblasts and fibrocytes and well vascularized" 13 "A majority of teeth in each experimental group showed coronally proliferation granulation tissue" 14 "Vital pulplike tissue was more frequently observed in CM-treated teeth with abundant vascular supplies" 15 "pulplike tissue (including fibroblasts and blood vessels) in the root canal did not connect with the periodontium tissue in the apex" 16 "The new vital tissue formed in the root canal space showed histologic characteristics of fibrous connective tissue similar to periodontal ligament" 17 "ingrowth of soft tissue into the canals from the periapical tissues were observed in all revascularized teeth", "In six cases, the connective tissue appeared to be more "fibrous and continuous with the apical periodontal ligament" "Remnants of normal pulp tissue were observed on the canal wall in two revascularized teeth"…”

Traditional and Current Treatment Methods from Apexification to Apexogenesis

“…69 Zhang ve ark. 70 TZP uygulamasının, apikal dokuda kanamanın bulunmadığı klinik olgular için bir seçenek olabileceğini belirtmişlerdir. Nekrotik, olgun köpek dişlerinde, kanal içi dezenfektan olarak üçlü antibiyotik patı ve iskele olarak TZP kullanımının revaskülarizasyon prosedürünün başarı oranını arttırdığı rapor edilmiştir.…”