Histologic evaluation of the healing potentiality of the human treated dentin matrix scaffold as direct pulp capping material

Abstract

Aim Find a reasonable substitution for current DPC materials. Methods The hTDM properties were evaluated by assessing its alkalinity, antibacterial activity, and potentiality to induce cell migration compared to MTA. The acute inflammatory response was evaluated 3 days after iatrogenic pulp exposure by histological examination. However, both chronic inflammatory response and dentin-pulp complex regeneration were evaluated after 3 months. Results The results of in vitro assessment revealed high alkalinity of MTA while hTDM exhibited optimum alkalinity. Moreover, the higher antibacterial activity and potentiality of inducing cell migration than MTA. The in vivo assessment ensured the ability of hTDM in optimizing the inflammatory response and dentin-pulp complex regeneration. However, MTA prolonged the inflammatory response and induced the formation of a thick calcific bridge toward the pulp tissue. Conclusion hTDM semi-rigid scaffold is a promising novel DPC material.