Histologic evidence of old intrauterine bleeding is more frequent in prematurity

miR-210 Targets Iron-Sulfur Cluster Scaffold Homologue in Human Trophoblast Cell Lines

“…To our knowledge, we show for the first time that increased siderosis of interstitial trophoblasts at the placental bed is another novel pathological feature of preterm preeclampsia and SGA pregnancies. The presence of hemosiderin is generally considered as evidence of old hemorrhage, 63 but our data strongly suggest that siderosis of interstitial trophoblasts is a consequence of nonhemorrhagic metabolic events, such as hypoxia and oxidative stress. Other studies also have shown both placental and systemic derangements of iron metabolism in preeclamptic patients.…”

Weakening and Rupture of Human Fetal Membranes – Biochemistry and Biomechanics

“…: periodontal infections) may also increase the levels of proinflammatory cytokines at the materno-fetal, interface (Offenbacher et al, 2006;Carta et al, 2004). Decidual hemorrhage/abruption is also highly associated with PPROM (Harger et al, 1990;Salafia et al, 1995). Additional risk factors include advanced maternal age, primiparity, (Ladfors et al, 2000) smoking, (Burguet et al, 2004) short cervical length structural abnormality of chorioamniotic membranes (Stuart et al, 2005), and PPROM with preterm birth in a previous pregnancy (Ladfors et al, 2000;Lee et al, 2003;Shen et al, 2008).…”

Abruptio placenta: A Retrospective Study on Aetiological Factors and Maternal Outcomes

“…Saftlaset.al and Naeye et.al showed an increased incidence of abruption among the socially deprived class. 11,12 Average age of study group was 26 years and for control group the average age was 24 (table 1). The standard deviation was 4.1 and 4.5 for group I and group II respectively.…”