Histologic examination of bone marrow core biopsy specimens has limited value in the diagnosis of mycobacterial and fungal infections in patients with the acquired immunodeficiency syndrome

Marques, Marisa B.; Waites, Ken B.; Jaye, David L.; Kilby, J Michael; Reddy, V.

doi:10.1016/s1092-9134(00)90002-9

Cited by 11 publications

(7 citation statements)

References 18 publications

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“…Some studies have suggested a limited use of this test 11 13. We show here that 24 of the 57 cases (42.1%) revealed inflammatory elements in the BM, including granulomas, lymphohistiocytic infiltrates and/or the presence of fungal yeasts.…”

Section: Discussionmentioning

confidence: 54%

“…The use of BM examinations to diagnose OIs increased as a result of the AIDS epidemic 1–3. The most common BM isolates in severely immunocompromised patients include Mycobacterium avium/intracellulare (MAI), Mycobacterium tuberculosis (MTB) and Histoplasma capsulatum , all of which have a propensity to disseminate and cause disease in patients with AIDS 12 13. A BM examination can implicate a particular organism if certain histological features are seen on biopsy.…”

Section: Introductionmentioning

confidence: 99%

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Utility of bone marrow examination for workup of fever of unknown origin in patients with HIV/AIDS

et al. 2015

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This study supports the use of diagnostic BMAB as a rapid decision-making tool in patients with HIV and FUO in the proper clinical setting. BMAB demonstrated infection-related evidence prior to positive bone marrow culture in 75% of cases. Special stains and blood cultures had similar diagnostic yield, but BMAB offers faster results. Thus, this procedure assists in clinical decision making and the refinement of treatment in a more timely manner.

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Section: Discussionmentioning

confidence: 54%

Section: Introductionmentioning

confidence: 99%

Utility of bone marrow examination for workup of fever of unknown origin in patients with HIV/AIDS

et al. 2015

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“…In the early days of the epidemic, many published studies evaluated the role of BMB, especially to elucidate persistent fever, secondary infections, cytopenias, and to stage malignancy. [1][2][3][4][5][6][7] After the advent of highly active antiretroviral therapy (HAART), the clinical course of HIV infection has dramatically improved. 8 As the clinical spectrum of this disease has changed, it is appropriate to reevaluate the performance of BMB as a diagnostic tool in the HAART scenario.…”

Section: Introductionmentioning

confidence: 99%

Changing patterns of AIDS: impact on the indications and diagnostic yield of bone marrow biopsies

Morais¹,

Machado²,

Biasoli³

et al. 2010

Braz J Infect Dis

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After the advent of HAART, the clinical course of HIV infection has dramatically improved. Therefore, it seems appropriate to reevaluate the performance of bone marrow biopsy (BMB) as a diagnostic tool. The aim of the present study was to compare the reasons for performing a BMB and its diagnostic yield in HIV-patients before and after HAART. A total of 165 BMB specimens obtained from HIV-infected patients receiving care at the Hospital of Universidade Federal do Rio de Janeiro in two different periods (1986-1994 and 1999-2004) were analysed. The main reason for BMB examination in the fi rst period was fever (88%), which decreased in the second period (57%, p < 0.0001), when cytopenia (51%) was the leading reason for BMB, whereas in the fi rst period it accounted for only 30% (p = 0.008). A defi nitive diagnosis (infection, granulomas or lymphomas) was obtained in 28% of patients in the fi rst period and in 19% during the second period (p = 0.20). The diagnosis turned out as infections decreased from 16% in period 1 to 2% in period 2 (p = 0.003). Despite the the limitations in the evaluation of fever, the use of BMB must be considered on an individual basis, whenever less invasive alternatives have been exhausted, and should be complemented by a bone marrow aspiration for microbiological studies.

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“…Blood and bone marrow aspirates have been reported to have similar mycobacterial yields 12 . Sputum cultures are traditionally carried out in resource-poor countries .…”

Section: Discussionmentioning

confidence: 99%

“…The sputum culture is much more sensitive than routine sputum microscopy as it is able to detect 10-100 AFB per μl. 12 Bone marrow aspirates turn out to yield a comparatively high rate of TB-positive results in a setting with a high incidence of HIV-disease and TB. 13 The main disadvantage of culture methods is not the need for more sophisticated resources and more qualified technicians or higher cost, but its slowness.…”

Section: Discussionmentioning

confidence: 99%

Granulomatous Lesions in Bone Marrow: A Case Series

Salkar¹,

Pankanti²,

Pankanti³

et al. 2016

IOSR

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Histologic examination of bone marrow core biopsy specimens has limited value in the diagnosis of mycobacterial and fungal infections in patients with the acquired immunodeficiency syndrome

Cited by 11 publications

References 18 publications

Utility of bone marrow examination for workup of fever of unknown origin in patients with HIV/AIDS

Utility of bone marrow examination for workup of fever of unknown origin in patients with HIV/AIDS

Changing patterns of AIDS: impact on the indications and diagnostic yield of bone marrow biopsies

Granulomatous Lesions in Bone Marrow: A Case Series

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