2007
DOI: 10.1038/modpathol.3800734
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Histologic features are important prognostic indicators in early stages lung adenocarcinomas

Abstract: This study attempts to evaluate the clinicopathologic features of mixed subtype adenocarcinomas and the prognostic implications of histopathology classifications. Surgical specimens from 141 patients with clinical stage I or II lung adenocarcinoma during the period 1992-2004 were included. These cases were classified into four groups defined by the extent of the bronchioloalveolar carcinoma component: group I: pure bronchioloalveolar carcinoma; group II: mixed subtype with predominant bronchioloalveolar carcin… Show more

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Cited by 132 publications
(93 citation statements)
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“…Adenocarcinomas with a predominant solid-type component are associated with poor prognosis. 23,24 In contrast, bronchioloalveolar carcinoma, a well-differentiated type that is associated with excellent prognosis, 25,26 expressed markers that are associated with differentiation, such as DC-Lamp, CC10 (Clara cells), and p63. There was no expression of Musashi-1 or KIT in this adenocarcinoma type.…”
Section: Discussionmentioning
confidence: 99%
“…Adenocarcinomas with a predominant solid-type component are associated with poor prognosis. 23,24 In contrast, bronchioloalveolar carcinoma, a well-differentiated type that is associated with excellent prognosis, 25,26 expressed markers that are associated with differentiation, such as DC-Lamp, CC10 (Clara cells), and p63. There was no expression of Musashi-1 or KIT in this adenocarcinoma type.…”
Section: Discussionmentioning
confidence: 99%
“…However, what these series have in common is the absence of lymph node metastasis in tumors with invasion or fibrosis o6.0 mm. [10][11][12][13] Screening CT scan identifies lung nodules with a predominance of air density, also known as groundglass opacity. Although not all ground-glass opacities are neoplastic, neoplastic ground-glass opacities have a high rate of correlation with subsequent histology of non-mucinous BAC or tumors with a predominance of lepidic pattern.…”
Section: Invasion-radiological Pathological and Treatment Consequencesmentioning
confidence: 99%
“…Minimally invasive adenocarcinoma (MIA) is defined as a small, solitary adenocarcinoma exhibiting a predominantly lepidic growth pattern and ≤5 mm invasion in the greatest dimension of any one plane. Several reports [9][10][11][12][13] have described patients with similarly defined lung MIA and a disease-specific survival rate of nearly 100%. Furthermore, some reports 14,15) have demonstrated that tumor malignancy depends on the maximum diameter or area of its solid component, excluding the ground-glass opacity (GGO) component.…”
Section: Introductionmentioning
confidence: 99%