2018
DOI: 10.1016/j.humpath.2018.07.014
|View full text |Cite
|
Sign up to set email alerts
|

Histologic features of autoimmune hepatitis: a critical appraisal

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

0
44
0
3

Year Published

2019
2019
2022
2022

Publication Types

Select...
8
1

Relationship

0
9

Authors

Journals

citations
Cited by 52 publications
(47 citation statements)
references
References 16 publications
0
44
0
3
Order By: Relevance
“…However, the detection of ANA and SMA is not specific for AIH, and these histological findings are occasionally observed in other etiologies of hepatitis. Indeed, Gurung et al 23 recently demonstrated that while Kupffer cell hyaline granules, prominence of plasma cells in portal tracts, and plasma-lymphocytic inflammation are significantly associated with AIH, rosette formation and emperipolesis lacked significance when compared to chronic hepatitis of other etiologies. Thus, no biomarkers with high sensitivity and specificity (such as anti-mitochondrial antibodies in primary biliary cholangitis) are available for AIH, and a combination of clinical parameters as diagnostic criteria has been used for the diagnosis of AIH.…”
Section: Presentationmentioning
confidence: 99%
“…However, the detection of ANA and SMA is not specific for AIH, and these histological findings are occasionally observed in other etiologies of hepatitis. Indeed, Gurung et al 23 recently demonstrated that while Kupffer cell hyaline granules, prominence of plasma cells in portal tracts, and plasma-lymphocytic inflammation are significantly associated with AIH, rosette formation and emperipolesis lacked significance when compared to chronic hepatitis of other etiologies. Thus, no biomarkers with high sensitivity and specificity (such as anti-mitochondrial antibodies in primary biliary cholangitis) are available for AIH, and a combination of clinical parameters as diagnostic criteria has been used for the diagnosis of AIH.…”
Section: Presentationmentioning
confidence: 99%
“…It is commonly accepted that macrophages are implicated in the pathological inflammation and fibrosis of liver diseases and activated macrophages are present in the portal area of AIH ( 26 – 28 ). Our previous studies have found that receptor-interacting protein kinase 3 (RIP3) signaling was involved in LPS-induced macrophage/monocyte activation in AIH ( 29 ).…”
Section: Introductionmentioning
confidence: 99%
“…Histologically, it is characterized by the presence of portal lymphoplasmacytic infiltration, interface hepatitis and lobulitis. [3] Treatment of AIH consists of steroids and various immunosuppressive agents including azathioprine, mycophenolate mofetil or tacrolimus. A biochemical remission is achieved with such agents in about 80-90% of the cases within two years.…”
Section: Introductionmentioning
confidence: 99%